Neurobiology of Social Thinking in Anorexia

厌食症社会思维的神经生物学

• 批准号: 8242554
• 负责人: Carrie Justine McAdams
• 金额: $ 17.15万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8242554
• 关键词: Adolescent; Adult; Anorexia; Anorexia Nervosa; Area; Behavioral; Biological; Biological Factors; Biological Neural Networks; Brain; Brain region; Characteristics; Clinical; Clinical Treatment; Competence; Data; Development; Diagnostic; Dorsal; Eating Disorders; Emotional; Emotions; Equipment and supply inventories; Female; Functional Magnetic Resonance Imaging; Glucose; Goals; Human; Impairment; Individual; Intervention; K-Series Research Career Programs; Knowledge; Link; Measures; Medical; Medical History; Mentors; Neurobiology; Neurocognitive; Participant; Pathology; Patients; Personality; Phenotype; Pilot Projects; Problem Solving; Process; Psychological Factors; Recording of previous events; Recovery; Request for Applications; Research; Research Personnel; Research Project Grants; Residencies; Resolution; Rest; Rewards; Sample Size; Self Concept; Self Perception; Severities; Social Identification; Social Problems; Staging; Starvation; Structure of superior temporal sulcus; Symptoms; Thinking; Time; Training; Treatment Protocols; Underweight; Weight; Woman; career; cognitive neuroscience; evidence base; improved; interest; meetings; neural circuit; neuroimaging; patient oriented; psychologic; relating to nervous system; self esteem; social; social cognition; theories; trait; young adult

DESCRIPTION (provided by applicant): This K-23 Mentored Patient-Oriented Career Development Award application requests support to provide training for the applicant to become a neuroimaging researcher in human cognitive neuroscience specializing in understanding the illness, anorexia nervosa and to perform a research project that will investigate the linkages between neural correlates of social thinking and the pathology of anorexia nervosa. During residency, the applicant's research background as a cortical neurophysiologist led her to begin a pilot project utilizing functional neuroimaging tasks in eating disorders. This project identified three cortical regions with different activation in thinking about one's own self-identity and understanding relationships between others in patients in the process of recovering from anorexia nervosa. The proposed project will now examine the activation of these regions: the cingulate, the precuneus, and the temporoparietal junction in three different subject groups: healthy controls, currently ill anorexia nervosa patients, and fully recovered anorexia nervosa patients. These comparisons will improve our understanding of cortical changes associated with illness and recovery in anorexia nervosa. In addition to the neuroimaging data, each participant will complete assessments providing psychiatric and medical history, psychological scales related to the fMRI tasks, and neurocognitive measures. Activation of these neural regions by the fMRI tasks will also be correlated with the assessments to distinguish between cortical differences that relate specifically to the presence of the illness and differences that relate to other psychological measures and may reflect a trait of patients that have anorexia nervosa. These studies will allow the applicant to meet her immediate career goal: development as an independent translational neuroimaging researcher in anorexia nervosa. With this study and training, the applicant will be prepared to meet her long-term career goal of becoming an independent investigator examining the relationship between biological mechanisms and psychological function in both the development and resolution of anorexia nervosa. PUBLIC HEALTH RELEVANCE: Anorexia nervosa is a serious psychiatric illness afflicting approximately 1% of adolescent and young adult women for which both causes and treatments are not understood. This research project examines how neural activation of cortical areas related to social thinking and identity differ between individuals with anorexia nervosa and individuals who have recovered from anorexia nervosa. This study will also improve our understanding of the relationship between psychological and biological factors in anorexia nervosa.

描述（由申请人提供）：该K-23指导了以患者为导向的职业发展奖申请申请请求支持，为申请人提供培训，使申请人成为人类认知神经科学领域的神经影像学研究者，专门了解疾病，厌食性神经性厌食症和进行研究项目，该项目将研究社会思维的神经相关性，并研究社会思维的神经相关性和厌氧性神经学的神经相关性。在居住期间，申请人作为皮质神经生理学家的研究背景使她开始使用功能性神经影像学任务的试点项目。该项目确定了三个具有不同激活的皮质区域，以思考自己的自我认同，并理解从神经性厌食症中恢复的患者中其他患者之间的关系。拟议的项目现在将检查这些区域的激活：三个不同受试者组中的扣带，前神经和颞叶交界处：健康对照组，目前患病的神经性厌食症患者，以及完全康复的神经性厌食症患者。这些比较将提高我们对与疾病和厌食性厌食症相关的皮质变化的理解。除了神经影像数据外，每个参与者还将完成提供精神病和病史的评估，与功能磁共振成像任务有关的心理量表以及神经认知措施。通过功能磁共振成像任务激活这些神经区域也将与评估相关，以区分与疾病的存在和与其他心理学措施有关的差异的皮质差异，并可能反映患有厌食症的患者的特征。这些研究将使申请人达到她的直接职业目标：作为神经性厌食症的独立翻译神经影像学研究者的发展。通过这项研究和培训，申请人将准备实现她的长期职业目标，即成为一名独立研究者，研究生物学机制与心理功能之间的关系在神经性厌食症的发展和解决方面。 公共卫生相关性：神经性厌食症是一种严重的精神病，遭受了大约1％的青少年和年轻妇女的痛苦，而这些妇女的原因和治疗都不被理解。该研究项目研究了神经性厌食症患者与从神经性厌食症恢复的个体之间的神经激活与社会思维和身份有关的皮质区域的神经激活。这项研究还将提高我们对神经性厌食症心理因素和生物学因素之间关系的理解。