MUSC Center for Oral Health Research

MUSC 口腔健康研究中心

• 批准号: 8921215
• 负责人: Keith L Kirkwood
• 金额: $ 102.85万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-05 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8921215
• 关键词: Accountability; Achievement; Affect; Area; Basic Science; Biology; Biomedical Engineering; Centers of Research Excellence; Chronic Disease; Clinical; Clinical Research; Complement; Core Facility; Data; Dental; Dental Care; Dental Schools; Dental caries; Diabetes Mellitus; Dietary Practices; Disease; Extramural Activities; Faculty; Fostering; Funding; Gnotobiotic; Goals; Grant; Growth; Growth and Development function; Health; Health Expenditures; Herpes Labialis; Human Resources; Infectious Disease Immunology; Institutes; Institution; Interdisciplinary Study; Investigation; Laboratories; Laboratory Animal Production and Facilities; Life; Link; Malignant Neoplasms; Malignant neoplasm of pharynx; Medicine; Mentors; Mouth Diseases; National Institute of Dental and Craniofacial Research; Oral; Oral health; Orofacial Pain; Paper; Peer Review; Periodontal Diseases; Phase; Pilot Projects; Positioning Attribute; Publishing; Recruitment Activity; Regenerative Medicine; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Training; Resources; Risk Factors; Schools; Services; South Carolina; Spottings; Strategic Planning; Therapeutic Intervention; Tissues; Tobacco use; Training Programs; Translational Research; United States; United States National Institutes of Health; Universities; abstracting; anticancer research; base; collaborative environment; college; community based participatory research; craniofacial; health disparity; laser capture microdissection; malignant mouth neoplasm; member; new technology; oral infection; programs; research facility; success; trend

With Phase III COBRE support, the MUSC Center for Oral Health Research (COHR) will complete its transition to long-term sustainability as a nationally competitive multidisciplinary research program in oral health. The COHR was conceived to expand the critical mass of funded investigators at MUSC in oral and craniofacial research and to enhance scientific core resources that serve as platforms to increase the capacity of our faculty to compete successfully for NIH funding. The COHR has mentored a total of 28 junior investigators to date, of which 17 have been promoted and 3 have earned tenure; 23 of the 28 have been retained at our institution. As a group, they have published more than 250 peer-reviewed papers and abstracts. They have received support from a total of 50 extramural grants, including 24 NIH grants on which they serve as PI or Key Personnel. The major components of this proposal are: A) The Administrative Core providing organizational, coordinating, fiscal and accountability functions; B) The Laboratory Core (L-COHR) providing services through four interactive facilities--the Gnotobiotic Animal Research Facility, Mineralized Tissue Facility, Oral Cancer Research Facility, and Laser Capture Microdissection Facility; C) The Clinical Core (C-COHR) fostering clinical and translational research and stimulating research discoveries through community-based participatory research; and D) The Pilot Project and Feasibility Projects Program providing support for pilot studies to foster research projects that utilize Center resources, personnel and facilities and facilitate interaction with COHR members. The COHR also has an NIH-funded research training component (T-COHR) that complements this proposal. The COHR's growth and activities have fueled a major cultural shift in the College of Dental Medicine and fostered recognition for oral health research at both campus and national levels. Research discoveries and grant success have created an interactive, supportive environment for research in the College of Dental Medicine. Thus, the Center for Oral Health Research is strategically positioned for long-term success as a critical resource for investigators developing new technologies, therapeutics and interventions to enhance the oral health of people in South Carolina and the United States.

在第三阶段 COBRE 的支持下，MUSC 口腔健康研究中心 (COHR) 将完成向长期可持续发展的转变，成为口腔健康领域具有全国竞争力的多学科研究项目。 COHR 的目的是扩大 MUSC 口腔和颅面研究领域受资助研究人员的临界数量，并增强科学核心资源，作为提高我们教师成功竞争 NIH 资助能力的平台。迄今为止，COHR 共指导了 28 名初级研究员，其中 17 人已晋升，3 人获得终身教职； 28 人中的 23 人已留在我们机构。作为一个团队，他们发表了 250 多篇经过同行评审的论文和摘要。他们总共获得了 50 项校外资助，其中包括 24 项 NIH 资助，其中他们担任 PI 或关键人员。该提案的主要组成部分是： A) 行政核心提供组织、协调、财政和问责职能； B) 实验室核心 (L-COHR) 通过四个互动设施提供服务——知生动物研究设施、矿化组织设施、口腔癌研究设施和激光捕获显微切割设施； C) 临床核心 (C-COHR) 通过基于社区的参与性研究促进临床和转化研究并刺激研究发现； D) 试点项目和可行性项目计划为试点研究提供支持，以促进利用中心资源、人员和设施并促进与 COHR 成员互动的研究项目。 COHR 还拥有 NIH 资助的研究培训部分 (T-COHR)，以补充该提案。 COHR 的发展和活动推动了牙科医学院的重大文化转变，并促进了校园和国家层面对口腔健康研究的认可。研究发现和资助成功为牙科医学院的研究创造了一个互动的、支持性的环境。因此，口腔健康研究中心的战略定位是长期成功，作为研究人员开发新技术、治疗方法和干预措施以增强南卡罗来纳州和美国人民口腔健康的关键资源。