Development of practical screening tools to support targeted prevention of early, high-risk drinking substance use

开发实用的筛查工具，以支持有针对性地预防早期高风险饮酒物质的使用

• 批准号: 10802793
• 负责人: William Ellerbe Pelham III
• 金额: $ 23.7万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-30 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10802793
• 关键词: 10 year old; 14 year old; Acceleration; Acute; Adolescence; Adolescent; Adult; Age; Alcohol abuse; Algorithm Design; Algorithms; Brain; Censuses; Child; Chronic; Cities; Clinical Services; Clinical effectiveness; Cognitive; Communities; Cost Savings; Data; Data Set; Development; Drug abuse; Drug usage; Ensure; Equity; Exhibits; Family; Gender Identity; Health Promotion; Individual; Inequity; Injury; Intervention; Investments; Link; Measures; Methodology; Methods; National Institute of Drug Abuse; Outcome; Outcome Assessment; Pattern; Performance; Population Heterogeneity; Prevention; Prevention program; Preventive; Preventive service; Procedures; Psychometrics; Public Health; Research; Resources; Risk; Risk Estimate; Risk Factors; Sampling; Schools; Screening procedure; Services; Site; Specific qualifier value; Stigmatization; Stretching; Substance Use Disorder; Surveys; Techniques; Testing; Trust; Validation; Victimization; Work; Youth; adolescent substance use; cohort; cost effective; cost effectiveness; ethnic identity; health inequalities; high risk; high risk drinking; improved; instrument; novel; peer; prevent; preventive intervention; programs; prospective; racial identity; resilience factor; screening; sexual identity; simulation; sociodemographics; substance use; success; tool; uptake

PROJECT SUMMARY/ABSTRACT Early, high-risk drinking and drug use during adolescence conveys risk of both acute harms and long-term consequences. NIDA has invested considerable resources in targeted prevention programs to reduce, delay, or mitigate these outcomes. The public health impact of these programs is limited by the current lack of a method to accurately and reliably identify which youth would benefit from these programs before they initiate substance involvement. Existing screening instruments to quantify risk among substance-naïve youth were developed in small, non-representative samples and have not yielded accurate and reliable predictions in new data. Responding to RFA-DA-24-037, Accelerating the Pace of Drug Abuse Research Using Existing Data, we propose to leverage the unprecedented Adolescent Brain and Cognitive DevelopmentSM (ABCD) Study to develop and conduct a preliminary validation of practical, accurate, and equitable screening tools for use in real- world prevention settings. The ABCD Study® is large (N=11,880), sociodemographically diverse, spans 21 cities across the U.S., measured every well-established risk/resilience factors for adolescent substance use, and will be followed prospectively for 10 years, enabling us to distinguish adolescents with early, high-risk drinking/drug use patterns from peers exhibiting developmentally normative, infrequent, and transient experimentation with substances. Thus, no prior study has offered a better opportunity for developing accurate and generalizable screening measures to quantify risk among substance-naïve youth. Aim 1: Develop a portfolio of brief, accurate, equitable, and generalizable screening measures. Following a systematic algorithm designed to maximize accuracy and eliminate inequities, we will construct and refine brief, survey-based measures quantifying risk for early, high-risk drinking and drug use. Aim 2: Conduct a preliminary validation of the developed screening measures in holdout data (n=5,000) weighted to be sociodemographically representative of all children in the U.S Census. To anticipate the tools’ likely performance in real-world settings, we will obtain unbiased estimates of screener performance in holdout data, then conduct sensitivity analyses probing potential limits on generalizability. Together, these aims have potential to deliver screening tools that can unlock the public health potential of existing targeted preventive interventions to reduce early, high-risk drinking/drug use, enabling wider implementation at cost-effective scale. This developmental/exploratory research (R21) leverages existing data to develop novel measures and conduct a preliminary validation. If we are successful at producing measures that yield accurate and equitable screening decisions in holdout data, we will further refine and externally validate the measure in a subsequent R01-scope project.

项目摘要/摘要 青春期期间的早期，高风险的饮酒和吸毒传达了急性危害和长期危险的风险 结果。 NIDA已在有针对性的预防计划上投入了大量资源，以减少，延迟或 减轻这些结果。这些计划的公共卫生影响受到当前缺乏方法的限制 准确，可靠地确定哪些年轻人在发起主题之前将从这些计划中受益 参与。现有的筛查工具以量化未来青年的风险的现有筛查工具已在 小的非代表性样本，在新数据中没有产生准确且可靠的预测。 响应RFA-DA-24-037，使用现有数据加速了药物滥用研究的速度，我们 利用前所未有的青少年大脑和认知发展（ABCD）研究的建议 开发和进行实用，准确且公平的筛选工具的初步验证，用于实现 世界预防环境。 ABCD研究®很大（n = 11,880），社会人口统计学多样，跨越21个城市 整个美国，测量了青少年物质使用的所有公认的风险/弹性因素，并将 前瞻性遵循10年，使我们能够与早期，高风险/毒品的青少年区分开 使用表现出发育正常，不频繁和瞬时实验的同龄人的模式 物质。这是没有先前的研究提供了更好的机会来开发准确且可推广的机会 筛选措施以量化未毒品的青年风险。目标1：制定简短，准确的投资组合 公平且可推广的筛查措施。遵循旨在最大化的系统算法 准确性并消除了不平等，我们将构建和完善基于调查的简短，基于调查的措施来量化风险 早期的高风险饮酒和吸毒。目标2：对已发达筛查进行初步验证 保留数据（n = 5,000）的措施在社会人口统计学上代表所有儿童 美国人口普查。为了预测工具在现实世界中的可能性能，我们将获得公正的估计 保留数据中的筛选器性能，然后进行灵敏度分析探测潜在限制 概括性。这些目标共同提供了可以释放公共卫生的筛查工具 现有有针对性的预防干预措施的潜力减少早期，高风险的饮酒/吸毒，使Wilder能够 以具有成本效益的规模实施。这项发展/探索性研究（R21）利用现有数据 开发新颖的测量并进行初步验证。如果我们成功地进行测量 在保留数据中，我们将获得准确且公平的筛选决策，我们将进一步完善并在外部验证 随后的R01-SCOPE项目中的度量。