21st Century Imaging Sciences: Graduate Student Training

21 世纪成像科学：研究生培训

• 批准号: 10006823
• 负责人: JOSEPH J. H. ACKERMAN
• 金额: $ 27.49万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10006823
• 关键词: Image; Science; graduate student; student training

Project Summary: Revolutionary advances in imaging drive discovery in the biomedical sciences. These advances in imaging depend on innovations in technology throughout the physical and biological sciences. In recent decades, a number of significant breakthroughs have underscored the importance of this interdependent relationship between technology and biomedical science. One important discovery that culminated in the 2008 Nobel Prize was the work of Tsien et al. that led to the structure, expression, and optimization of fluorescent proteins for biomedical imaging applications. There have been other key discoveries in the areas of imaging technology, contrast agents and clinical applications. For example, multimodality imaging, including PET/CT and PET/MR, has evolved at a rapid pace, along with development of image fusion technology for combining data sets from multimodal imaging studies obtained at various biological scales, spatial and temporal resolutions. Major advances in multimodality nanoparticle based imaging agents have taken advantage of the myriad of imaging platforms, from microscopy to MRI and PET. Hyperpolarized 13C MR in concert with simultaneous 11C PET employing state-of-the-art PET/MR scanners promises a revolution in preclinical and clinical molecular imaging. Advances in optical techniques have continued a rapid pace with most recently, super resolution microscopy (Nobel Prize in chemistry, 2014), and optogenetics (Keio Medical Science Prize, 2014) revolutionizing the biological sciences. What are the challenges and frontier domains of imaging sciences in the 21st century? The following examples describe challenges that are interconnected with advances in basic and translational sciences. (1) With progress in cell therapy and tissue engineering, noninvasive imaging of stem cells will be needed to ascertain delivery to target sites. (2) More hybrid imaging systems will be developed, such as PET and optical or photoacoustic imaging. (3) Nanoparticles with multimodality imaging capabilities and drug payloads will be optimized and moved into clinical trials. These challenges must be met by interdisciplinary teams of engineers, physicists, computer scientists, mathematicians, chemists, biologists, and physicians working together at the interfaces between biology, technology, and medicine to develop new imaging technologies, modalities, and applications. Washington University therefore launched the Imaging Sciences Pathway (ISP), initially through a T90-R90 Roadmap Initiative grant through 2010. This proposal requests continued support under a broad-based T32 mechanism for the interdisciplinary training of predoctoral students in our Imaging Sciences Pathway.

项目摘要： 革命性成像推动生物医学科学发现的进步。这些进步 成像取决于整个物理和生物科学的技术创新。最近 几十年来，许多重大突破强调了这种相互依存的重要性 技术与生物医学科学之间的关系。一个重要的发现，达到了 2008年诺贝尔奖是Tsien等人的作品。这导致了结构，表达和优化 用于生物医学成像应用的荧光蛋白。在 成像技术，对比剂和临床应用领域。例如，多模态 包括PET/CT和PET/MR在内的成像以快速发展，图像的发展 融合技术用于结合来自各种生物学的多模式成像研究的数据集 尺度，空间和时间分辨率。基于多模式纳米颗粒成像的重大进展 从显微镜到MRI和PET，代理已经利用了无数的成像平台。 超极化13C MR与同时使用最先进的宠物/MR同时发生的11C宠物 扫描仪有望在临床前和临床分子成像中进行革命。光学进展 最近，技术与最近的超级分辨率显微镜（诺贝尔奖奖 化学，2014年）和光遗传学（Keio医学科学奖，2014年），彻底改变了生物学 科学。 21世纪成像科学的挑战和前沿领域是什么？下列 例子描述了与基础科学和转化科学进步相关的挑战。 （1）随着细胞治疗和组织工程方面的进展，干细胞的无创成像将是 需要确定向目标站点的交付。 （2）将开发更多的混合成像系统，例如 宠物，光学或光声成像。 （3）具有多模式成像功能的纳米颗粒和 药物有效载荷将被优化，并进入临床试验。这些挑战必须由 跨学科的工程师，物理学家，计算机科学家，数学家，化学家，化学家，化学家团队 生物学家和医生在生物学，技术和医学之间的界面上共同努力 开发新的成像技术，方式和应用。因此，华盛顿大学 最初通过T90-R90路线图倡议Grant启动了Imaging Sciences Pathway（ISP） 到2010年。该提案要求在基于广泛的T32机制下继续支持 在我们的成像科学途径中对学位学生的跨学科培训。