REQUEST TO PURCHASE A 400 MHZ NMR SPECTROMETER

请求购买 400 MHZ 核磁共振波谱仪

• 批准号: 7794739
• 负责人: JOSEPH J. H. ACKERMAN
• 金额: $ 24.47万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-17 至 2012-07-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7794739
• 关键词: Academic Medical Centers; Address; Architecture; Area; Biochemical; Biomedical Research; Chemicals; Communication; Communities; Electronics; Funding; Generations; Heart; Institution; Medical center; National Center for Research Resources; Nuclear Magnetic Resonance; Request for Proposals; Research; Research Personnel; Resolution; Resources; Solutions; Synthesis Chemistry; System; Techniques; Technology; Time; United States National Institutes of Health; Universities; Washington; Writing; cost; design; digital; instrument; instrumentation; programs; tool

DESCRIPTION (provided by applicant): Washington University (WU) in St Louis is among the nation's top research institutions and supports extensive research at its two primary campuses, Danforth and medical center, which are separated from each other by a distance of three miles. The WU High Resolution Nuclear Magnetic Resonance Facility is the University's only open access resource for solution-state analytical and structural NMR applications. Each year for over two decades it has served in excess of 40 separate chemical, biochemical and biomedical research groups from both campuses. Nevertheless, because the NMR Facility's entire suite of instrumentation is located solely on the Danforth Campus, WU's medical center campus researchers have not had immediate nearby access to NMR analysis, as is required of modern, biologically oriented, synthetic chemistry. This has proven to be a significant hardship and substantive hindrance to ongoing NIH funded research. To address this problem, the WU NMR Facility requests NCRR SIG funding to purchase a 400 MHz NMR spectrometer to be located at the WU medical center campus. For the first time, WU medical center campus researchers will have convenient and immediate access to this powerful analytical technique. This application was written at the urging of established, NIH funded, WU medical center campus researchers who require significantly enhanced access to analytical and structural NMR tools. The proposal requests funds of $244,680, which combined with internal matching funds of $80,000 are sufficient to purchase the requested instrument, a 400 MHz (9.4 tesla) Varian, Inc. (Palo Alto) DirectDrive" system. Advances in NMR instrument technology during the past decade, in particular in the areas of superconducting magnet and dewar design, and digital control and communications, provide extraordinary spectrometer capabilities at modest cost. The DirectDrive" architecture represents a new generation of console technology from Varian, one that leverages the tremendous advances in digital electronics of the past decade. Locating the requested instrument at the WU medical center campus will immediately and significantly benefit ongoing NIH funded research programs, bringing the versatile and powerful tools of solution-state NMR analysis into the heart of WU's biomedical investigator community.

描述（由申请人提供）：圣路易斯的华盛顿大学（WU）是美国顶级研究机构之一，并在其两个主要校园Danforth和医疗中心支持广泛的研究，这些研究彼此相距三英里。 WU高分辨率核磁共振设施是大学分析和结构NMR应用的唯一开放访问资源。每年二十年来，这两个校园都超过40种独立的化学，生化和生物医学研究小组。然而，由于NMR设施的整个仪器套件仅位于丹佛斯校园，因此WU的医疗中心校园的研究人员没有立即获得NMR分析的访问，这是现代，面向生物学的合成化学的要求。事实证明，这是对正在进行的NIH资助研究的巨大困难和实质性的障碍。为了解决这个问题，Wu NMR设施要求NCRR SIG资金购买400 MHz NMR光谱仪位于WU医疗中心校园。 WU Medical Center校园研究人员首次将可以方便而立即进入这种强大的分析技术。该申请是在敦促已建立的NIH资助的WU医疗中心校园研究人员的敦促，他们需要显着增强获得分析和结构性NMR工具的访问。该提案要求提供244,680美元的资金，再加上80,000美元的内部匹配资金，足以购买所需的乐器，一个400 MHz（9.4 Tesla）Varian Inc.（Palo Alto）DirectDrive“ DirectDrive”系统。谦虚成本的功能。在WU医疗中心校园找到所需的工具将立即并显着受益于正在进行的NIH资助的研究计划，将解决方案状态NMR分析的多功能和强大工具带入WU的生物医学研究员社区的核心。