REQUEST TO PURCHASE A 400 MHZ NMR SPECTROMETER

请求购买 400 MHZ 核磁共振波谱仪

• 批准号: 7794739
• 负责人: JOSEPH J. H. ACKERMAN
• 金额: $ 24.47万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-17 至 2012-07-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7794739
• 关键词: Academic Medical Centers; Address; Architecture; Area; Biochemical; Biomedical Research; Chemicals; Communication; Communities; Electronics; Funding; Generations; Heart; Institution; Medical center; National Center for Research Resources; Nuclear Magnetic Resonance; Request for Proposals; Research; Research Personnel; Resolution; Resources; Solutions; Synthesis Chemistry; System; Techniques; Technology; Time; United States National Institutes of Health; Universities; Washington; Writing; cost; design; digital; instrument; instrumentation; programs; tool

DESCRIPTION (provided by applicant): Washington University (WU) in St Louis is among the nation's top research institutions and supports extensive research at its two primary campuses, Danforth and medical center, which are separated from each other by a distance of three miles. The WU High Resolution Nuclear Magnetic Resonance Facility is the University's only open access resource for solution-state analytical and structural NMR applications. Each year for over two decades it has served in excess of 40 separate chemical, biochemical and biomedical research groups from both campuses. Nevertheless, because the NMR Facility's entire suite of instrumentation is located solely on the Danforth Campus, WU's medical center campus researchers have not had immediate nearby access to NMR analysis, as is required of modern, biologically oriented, synthetic chemistry. This has proven to be a significant hardship and substantive hindrance to ongoing NIH funded research. To address this problem, the WU NMR Facility requests NCRR SIG funding to purchase a 400 MHz NMR spectrometer to be located at the WU medical center campus. For the first time, WU medical center campus researchers will have convenient and immediate access to this powerful analytical technique. This application was written at the urging of established, NIH funded, WU medical center campus researchers who require significantly enhanced access to analytical and structural NMR tools. The proposal requests funds of $244,680, which combined with internal matching funds of $80,000 are sufficient to purchase the requested instrument, a 400 MHz (9.4 tesla) Varian, Inc. (Palo Alto) DirectDrive" system. Advances in NMR instrument technology during the past decade, in particular in the areas of superconducting magnet and dewar design, and digital control and communications, provide extraordinary spectrometer capabilities at modest cost. The DirectDrive" architecture represents a new generation of console technology from Varian, one that leverages the tremendous advances in digital electronics of the past decade. Locating the requested instrument at the WU medical center campus will immediately and significantly benefit ongoing NIH funded research programs, bringing the versatile and powerful tools of solution-state NMR analysis into the heart of WU's biomedical investigator community.

描述（由申请人提供）：位于圣路易斯的华盛顿大学 (WU) 是美国顶尖的研究机构之一，支持其两个主校区（丹福斯校区和医学中心）的广泛研究，这两个校区相距三英里。西弗吉尼亚大学高分辨率核磁共振设施是该大学唯一用于溶液状态分析和结构核磁共振应用的开放获取资源。二十多年来，它每年都为两个校区的 40 多个独立的化学、生物化学和生物医学研究小组提供服务。然而，由于 NMR 设施的整套仪器仅位于丹福斯校区，西弗吉尼亚大学医学中心校区的研究人员无法立即在附近进行 NMR 分析，而这是现代生物导向合成化学所需要的。事实证明，这对正在进行的 NIH 资助的研究来说是一个重大困难和实质性障碍。为了解决这个问题，WU NMR 设施请求 NCRR SIG 资助购买一台 400 MHz NMR 波谱仪，安装在 WU 医疗中心园区。西弗吉尼亚大学医学中心校园研究人员将首次方便快捷地使用这种强大的分析技术。该应用程序是在 NIH 资助的 WU 医学中心校园研究人员的敦促下编写的，他们需要显着增强对分析和结构 NMR 工具的访问。该提案请求资金 244,680 美元，再加上 80,000 美元的内部配套资金，足以购买所需的仪器，即 400 MHz（9.4 特斯拉）Varian, Inc.（帕洛阿尔托）DirectDrive”系统。过去 NMR 仪器技术的进步十年来，特别是在超导磁体和杜瓦瓶设计以及数字控制和通信领域，以适中的成本提供了非凡的光谱仪功能。“DirectDrive”架构代表了一种新的技术。瓦里安新一代控制台技术，利用了过去十年数字电子技术的巨大进步。在 WU 医学中心校园找到所需的仪器将立即显着有利于正在进行的 NIH 资助的研究项目，将溶液状态 NMR 分析的多功能且强大的工具带入 WU 生物医学研究人员社区的核心。