21st Century Imaging Sciences: Graduate Student Training

21 世纪成像科学：研究生培训

• 批准号: 9280509
• 负责人: JOSEPH J. H. ACKERMAN
• 金额: $ 28.2万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9280509
• 关键词: Image; Science; graduate student; student training

Project Summary: Revolutionary advances in imaging drive discovery in the biomedical sciences. These advances in imaging depend on innovations in technology throughout the physical and biological sciences. In recent decades, a number of significant breakthroughs have underscored the importance of this interdependent relationship between technology and biomedical science. One important discovery that culminated in the 2008 Nobel Prize was the work of Tsien et al. that led to the structure, expression, and optimization of fluorescent proteins for biomedical imaging applications. There have been other key discoveries in the areas of imaging technology, contrast agents and clinical applications. For example, multimodality imaging, including PET/CT and PET/MR, has evolved at a rapid pace, along with development of image fusion technology for combining data sets from multimodal imaging studies obtained at various biological scales, spatial and temporal resolutions. Major advances in multimodality nanoparticle based imaging agents have taken advantage of the myriad of imaging platforms, from microscopy to MRI and PET. Hyperpolarized 13C MR in concert with simultaneous 11C PET employing state-of-the-art PET/MR scanners promises a revolution in preclinical and clinical molecular imaging. Advances in optical techniques have continued a rapid pace with most recently, super resolution microscopy (Nobel Prize in chemistry, 2014), and optogenetics (Keio Medical Science Prize, 2014) revolutionizing the biological sciences. What are the challenges and frontier domains of imaging sciences in the 21st century? The following examples describe challenges that are interconnected with advances in basic and translational sciences. (1) With progress in cell therapy and tissue engineering, noninvasive imaging of stem cells will be needed to ascertain delivery to target sites. (2) More hybrid imaging systems will be developed, such as PET and optical or photoacoustic imaging. (3) Nanoparticles with multimodality imaging capabilities and drug payloads will be optimized and moved into clinical trials. These challenges must be met by interdisciplinary teams of engineers, physicists, computer scientists, mathematicians, chemists, biologists, and physicians working together at the interfaces between biology, technology, and medicine to develop new imaging technologies, modalities, and applications. Washington University therefore launched the Imaging Sciences Pathway (ISP), initially through a T90-R90 Roadmap Initiative grant through 2010. This proposal requests continued support under a broad-based T32 mechanism for the interdisciplinary training of predoctoral students in our Imaging Sciences Pathway.

项目概要： 成像的革命性进步推动了生物医学的发现。这些进步 成像依赖于整个物理和生物科学的技术创新。近来 几十年来，许多重大突破凸显了这种相互依存的重要性 技术与生物医学之间的关系。一项重要的发现最终导致 2008年诺贝尔奖是钱学森等人的成果。这导致了结构、表达和优化 用于生物医学成像应用的荧光蛋白。在此过程中还有其他重要发现 成像技术、造影剂和临床应用领域。例如，多模态 随着图像技术的发展，包括 PET/CT 和 PET/MR 在内的成像技术也在快速发展。 融合技术，用于组合从各种生物获得的多模态成像研究的数据集 尺度、空间和时间分辨率。基于多模态纳米颗粒成像的重大进展 代理已经利用了无数的成像平台，从显微镜到 MRI 和 PET。 超极化 13C MR 与采用最先进 PET/MR 的同步 11C PET 相结合 扫描仪有望带来临床前和临床分子成像的革命。光学方面的进展 最近，超分辨率显微镜技术继续快速发展（诺贝尔奖 化学，2014）和光遗传学（庆应义塾医学科学奖，2014）彻底改变了生物技术 科学。 21世纪成像科学的挑战和前沿领域是什么？下列 例子描述了与基础科学和转化科学的进步相关的挑战。 (1)随着细胞治疗和组织工程的进步，干细胞的无创成像将成为可能 需要确定是否交付到目标地点。 (2)将开发更多的混合成像系统，例如 PET 和光学或光声成像。 (3) 具有多模态成像能力的纳米颗粒和 药物有效负载将得到优化并进入临床试验。这些挑战必须通过 由工程师、物理学家、计算机科学家、数学家、化学家组成的跨学科团队， 生物学家和医生在生物学、技术和医学之间的交叉领域合作 开发新的成像技术、模式和应用。因此华盛顿大学 启动了成像科学途径 (ISP)，最初是通过 T90-R90 路线图计划拨款 到 2010 年。该提案要求在基础广泛的 T32 机制下继续提供支持 在我们的成像科学途径中对博士前学生进行跨学科培训。