REQUEST TO PURCHASE A VARIAN HIGH RESOLUTION NMR REPLACEMENT CONSOLE

请求购买 VARIAN 高分辨率 NMR 替换控制台

• 批准号: 7794735
• 负责人: JOSEPH J. H. ACKERMAN
• 金额: $ 23.94万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-04 至 2011-02-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7794735
• 关键词: Aging; Anesthesiology; Area; Back; Biochemistry; Biophysics; Cardiology; Chemistry; Commit; Communication; DNA Structure; Engineering; Funding; Health; Heart; Hour; Housing; Internal Medicine; Light; Magic; Magnetic Resonance; Maintenance; Malignant Neoplasms; Metabolism; Molecular; Molecular Biology; Molecular Structure; Neurology; Ophthalmology; Organism; Pathology; Pharmacology; Physics; Principal Investigator; Radiation Oncology; Radiology Specialty; Research; Resolution; Resources; Sampling; Seasons; Services; Sum; Time; Tissues; Training; Universities; Washington; base; diabetic; instrument; interest; relating to nervous system

DESCRIPTION (provided by applicant): The Washington University High Resolution NMR Facility requests funding to purchase a Varian DirectDriveT console for an aging 500 MHz NMR instrument and a magic angle sample spinning NanoprobeT to allow for studies of metabolite profiles from cancer tissues. These requests are for supplementing and modernizing a shared magnetic resonance resource that serves 38 separate research groups spanning departments of Anesthesiology, Biochemistry & Molecular Biophysics, Chemistry, Cardiology, Engineering, Internal Medicine, Neurology, Ophthalmology, Pathology, Pharmacology & Molecular Biology, Physics, Radiation Oncology, and Radiology. The NMR Facility is an active resource housing five instruments and staffed with seasoned professionals committed to user training and collaborative research. The Facility is open and available 24 hours a day, 365 days a year and committed to service for its extensive user base. This request is prompted by significant down time and maintenance expense associated with the existing Facility 500 MHz instrument that dates back to 1986. This instrument has served research needs for dozens of principal investigators for over two decades and is now dated and unreliable. The scientific basis for this proposal spans a user group with longstanding interests in health related issues. These including research areas of light initiated alterations of DNA structure, the creation of molecular structures that mimic neural communication networks, understanding markers for the genesis of and recognition of cancer, tissue damage caused by reactive oxidative molecules in living systems, and understanding the altered metabolism of the diabetic heart. This request, $314,395, is made with a financial matching commitment from Washington University in the sum of $75,000.

描述（由申请人提供）：华盛顿大学高分辨率NMR设施要求资金购买500 MHz NMR仪器的Varian DirectDrivet控制台和旋转纳米op的魔法角度样本，以允许从癌症组织中研究代谢物概况。这些请求是为了补充和现代化共享的磁共振资源，该资源为38个单独的研究小组提供了麻醉，生物化学和分子生物物理学，化学，心脏病学，工程，内科，神经病学，眼科，病理学，病理学和分子生物学，物理学，物理学，辐射，辐射，和放射学。 NMR设施是一种活跃的资源，拥有五种乐器，并配备了经验丰富的专业人士，他们致力于用户培训和协作研究。该设施是开放的，每年365天每天24小时可用，并致力于为其广泛的用户群提供服务。这项要求是由与现有的500 MHz工具相关的大量停机时间和维护费用促成的，该工具可以追溯到1986年。该工具已经满足了数十家主要研究人员的研究需求，已有二十年多了，现在已经过时且不可靠。该提案的科学基础涵盖了一个对健康相关问题的用户组。这些包括光的研究领域引发了DNA结构的改变，模仿神经通信网络的分子结构的创建，了解癌症的起源和识别的标志物，生命系统中的反应性氧化分子引起的组织损伤以及了解糖尿病心脏的代谢改变。该请求是314,395美元，是由华盛顿大学的财务匹配承诺制成的75,000美元。