UAB Research Education Program for Residents and Fellows in Neuroscience

阿拉巴马大学神经科学住院医师和研究员研究教育计划

• 批准号: 10332854
• 负责人: DAVID G. STANDAERT
• 金额: $ 7.97万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10332854
• 关键词: Academic Medical Centers; Address; Aging; Alabama; Alzheimer' s Disease; Anesthesiology; Area; Award; BRAIN initiative; Basic Science; Beds; Behavior; Biomedical Research; Catchment Area; Cerebrovascular Disorders; Clinic; Clinical; Clinical Research; Clinical Sciences; Development; Discipline; Education Projects; Educational Activities; Educational workshop; Environment; Epilepsy; Ethics; Faculty; Funding; Genetic; Genomics; Goals; Health; Health Status; Healthcare; Human; Individual; Institutes; Institution; K-Series Research Career Programs; Knowledge; Leadership; Mentors; Mission; National Institute of Neurological Disorders and Stroke; Neurodegenerative Disorders; Neurology; Neurosciences; Neurosciences Research; Neurosurgeon; Pain; Parkinson Disease; Persons; Physicians; Population; Positioning Attribute; Prevalence; Provider; Public Health; Radiology Specialty; Reporting; Reproducibility; Research; Research Training; Residencies; Resources; Role; Science; Scientist; Site; Societies; Synaptic plasticity; Teacher Professional Development; Training; Training Programs; Translational Research; United States National Institutes of Health; Universities; University Hospitals; base; career; clinically relevant; education research; experience; interest; member; metropolitan; nervous system disorder; neuro-oncology; neurochemistry; neurodevelopment; neuropathology; neurosurgery; news; operation; professor; programs; responsible research conduct; skills; success

Abstract This is a proposal for renewal of an NINDS R25 program. The Specific Aim of this proposal is to support educational activities that will enable physician-scientists training in neurology, neurosurgery, radiology, anesthesiology and neuropathology or related fields to compete successfully for mentored career development awards, or similar major research awards. This training program addresses the critical needs posed by an increasingly aging US population, which are leading to a greater prevalence of neurological disorders. The scientific successes of the last two decades have resulted in a vast expansion of knowledge. To close the gap between these advances in knowledge and clinically meaningful benefits to human health, a strong cadre of clinical neuroscientists with the skills to engage in basic, translational and clinical research is essential. The University of Alabama at Birmingham (UAB) is exceptionally well positioned to undertake this task. It is a large metropolitan university with a 380-acre contiguous campus. It is a Carnegie Class-I biomedical research organization, with current research funding of over $570 million per year. It is also a major provider of tertiary- level health care serving a catchment area of over 8 million people, and the educational, research, and health care missions of the institution are closely integrated. The environment for neuroscience research and training has grown dramatically at UAB in recent years. Funding from NIH Institutes which support primarily neuroscience research has doubled from $40M to nearly $80M. Support from NINDS has climbed even more dramatically, from $8.5M in 2005 to the current level of more than $24M. Important new NIH-funded centers and programs include the Morris K. Udall Center of Excellence in Parkinson Research, an Exploratory Alzheimer Disease Center, NeuroNEXT and StrokeNET sites, and a Brain Initiative program. Dr. David Standaert, Professor and Chair of Neurology at UAB and Program Director of the current R25 program remains in this role. Taking on an expanded role in this R25, Dr. James Markert, Professor and Chair of Neurosurgery, will serve as Co-Director. Dr. Markert is an academic neurosurgeon with a very active NIH- funded research portfolio. The training faculty are a diverse group of 33 accomplished neuroscientists. Four themes form the framework of the R25 program: Neuro-oncology; Neurodegenerative disease; Synaptic plasticity, pain and epilepsy; and Cerebrovascular disease. Each of the themes has a faculty member designated to coordinate this area. The program includes training in ethical and successful scientific practices, conducting reproducible science, and the responsible conduct of research as well as participation in the annual NINDS R25 workshop.

抽象的 这是续签Ninds R25计划的建议。该提议的具体目的是支持 教育活动将使医师科学家在神经病学，神经外科，放射学，放射学， 麻醉学和神经病理学或相关领域，以成功竞争指导的职业发展 奖项或类似的主要研究奖。 该培训计划解决了越来越老化的美国人口所带来的关键需求， 导致神经系统疾病的患病率更大。过去二十年的科学成功 已经导致了大量知识。弥合这些知识进步和 对人类健康的临床意义上有意义的好处，这是一群具有临床神经科学家的干部 从事基础，转化和临床研究至关重要。 伯明翰（UAB）的阿拉巴马大学非常适合执行这项任务。是一个 大都市大学，拥有380英亩的连续校园。这是卡内基I类生物医学研究 组织，目前的研究资金每年超过5.7亿美元。它也是第三级的主要提供商 水平医疗保健为超过800万人的集水区提供服务，以及教育，研究和健康 该机构的护理任务紧密整合。 近年来，神经科学研究和培训的环境在UAB急剧发展。 NIH研究所的资金主要支持神经科学研究 8000万美元。 Ninds的支持更加巨大，从2005年的850万美元到目前的水平 超过2400万美元。重要的新型NIH资助中心和计划包括莫里斯·K·乌德尔中心 帕金森研究卓越，探索性阿尔茨海默氏病中心，Neuronext和Strokenet 网站和大脑倡议计划。 UAB神经病学教授兼主席兼现任R25的计划主任David Standaert博士 程序仍然处于这个角色。在此R25中扮演的角色扩大，教授兼主席James Markert博士 神经外科将担任联合导演。 Markert博士是一位学术神经外科医生，具有非常活跃的NIH- 资助的研究组合。培训学院是一个由33位成熟的神经科学家组成的多样化组。 四个主题构成了R25计划的框架：神经肿瘤学；神经退行性疾病；突触 可塑性，疼痛和癫痫；和脑血管疾病。每个主题都有一个教师 指定以协调该区域。 该计划包括在道德和成功的科学实践中进行培训，进行可重复的科学， 以及负责任的研究以及参加年度NINDS R25研讨会。

项目成果

Genome-wide Association Identifies Novel Etiological Insights Associated with Parkinson's Disease in African and African Admixed Populations.

全基因组协会确定了与非洲和非洲混合人群帕金森病相关的新病因学见解。

• DOI: 10.1101/2023.05.05.23289529
• 发表时间: 2023
• 期刊: medRxiv : the preprint server for health sciences
• 作者: Rizig,Mie;Bandres-Ciga,Sara;Makarious,MaryB;Ojo,Oluwadamilola;Crea,PeterWild;Abiodun,Oladunni;Levine,KristinS;Abubakar,Sani;Achoru,Charles;Vitale,Dan;Adeniji,Olaleye;Agabi,Osigwe;Koretsky,MathewJ;Agulanna,Uchechi;Hall,Debo
• 通讯作者: Hall,Debo

Letter: Recognizing the Impact of Campus Visits During the 2022 to 2023 Neurosurgical Resident Recruitment Cycle.

信件：认识到 2022 年至 2023 年神经外科住院医师招聘周期期间校园访问的影响。

• DOI: 10.1227/neu.0000000000002485
• 发表时间: 2023
• 期刊: Neurosurgery
• 影响因子: 4.8
• 作者: Laskay,NicholasMB;Estevez-Ordonez,Dagoberto;Atchley,TravisJ;Rozzelle,CurtisJ
• 通讯作者: Rozzelle,CurtisJ

Basal Synaptic Transmission and Long-Term Plasticity at CA3-CA1 Synapses Are Unaffected in Young Adult PINK1-Deficient Rats.

• DOI: 10.3389/fnins.2021.655901
• 发表时间: 2021
• 期刊: Frontiers in neuroscience
• 影响因子: 4.3
• 作者: Memon AA;Bagley ME;Creed RB;Amara AW;Goldberg MS;McMahon LL
• 通讯作者: McMahon LL

Behavioral Improvements following Lesion Resection for Pediatric Epilepsy: Pediatric Psychosurgery?

小儿癫痫病灶切除后的行为改善：小儿精神外科？

• DOI: 10.1159/000529683
• 发表时间: 2023
• 期刊: Pediatric neurosurgery
• 影响因子: 0.7
• 作者: Dang,Huy;Khan,AbdulBasit;Gadgil,Nisha;Sharma,Himanshu;Trandafir,Cristina;Malbari,Fatema;Weiner,HowardL
• 通讯作者: Weiner,HowardL

Endovascular thrombectomy for the treatment of large ischemic stroke: a systematic review and meta-analysis of randomized control trials.

血管内血栓切除术治疗大面积缺血性卒中：随机对照试验的系统评价和荟萃分析。

• DOI: 10.1101/2023.02.27.23286534
• 发表时间: 2023
• 期刊: medRxiv : the preprint server for health sciences
• 作者: Atchley,TravisJ;Estevez-Ordonez,Dagoberto;Laskay,NicholasMB;Tabibian,BornaE;Harrigan,MarkR
• 通讯作者: Harrigan,MarkR