Attentional Mechanisms of Cognitive Compensation in Subjective Cognitive Decline and AD Risk

主观认知下降和 AD 风险中认知补偿的注意机制

• 批准号: 10738600
• 负责人: Kimberly Albert
• 金额: $ 11.16万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10738600
• 关键词: Academic Medical Centers; Address; Affect; Aging; Alzheimer' s Disease; Alzheimer' s disease model; Alzheimer' s disease pathology; Alzheimer' s disease risk; Amyloid beta-42; Amyloidosis; Anti-Cholinergics; Area; Attention; Behavioral Sciences; Brain; Clinical; Clinical Research; Clinical Trials; Cognition; Cognition Disorders; Cognitive; Cognitive aging; Collaborations; Compensation; Complement; Deterioration; Development; Disease Progression; Doctor of Philosophy; Elderly; Electroencephalography; Environment; Experimental Models; Failure; Functional Magnetic Resonance Imaging; Funding; Future; Goals; Human; Impaired cognition; Impairment; Individual; Intervention; Intervention Studies; K-Series Research Career Programs; Leadership; Maintenance; Measures; Medial; Medicine; Memory; Mentors; Neurobiology; Neurosciences; Neurotransmitters; Pathologic; Pathology; Performance; Pharmaceutical Preparations; Pharmacologic Substance; Placebos; Process; Psyche structure; Psychiatry; Research; Research Personnel; Research Project Grants; Research Proposals; Resources; Role; Severities; System; Temporal Lobe; Testing; Therapeutic; Training; Translating; Work; aging brain; basal forebrain; career; career development; cholinergic; clinical diagnosis; cognitive change; cognitive enhancement; cognitive function; cognitive neuroscience; cognitive performance; cognitive process; cognitive testing; experience; functional magnetic resonance imaging/electroencephalography; improved; neurobiological mechanism; neuroimaging; neuropathology; pre-clinical; preservation; professor; research study; tau Proteins; temporal measurement

Attentional Mechanisms of Cognitive Compensation in Subjective Cognitive Decline and AD Risk Candidate: Dr. Kimberly Albert, PhD is an assistant professor in the Department of Psychiatry and Behavioral Sciences at the Vanderbilt University Medical Center with a strong background in cognitive and systems neuroscience. Her long-term career goals include gaining the necessary training to become an independent investigator with research focused on identifying brain mechanisms that maintain cognitive function in the early stages of pathological brain aging and may underlie subjective cognitive decline (SCD). Career Development: Dr. Albert seeks to translate her mechanistic work to clinical research that mitigates the cognitive effects of early AD pathology. Dr. Albert requires advanced training in 1) clinical trials development, implementation, and management.; 2) the clinical presentation, course, and assessment of SCD and Alzheimer’s Disease; 3) neuroimaging using EEG/ERP to provide the temporal resolution to assess brain activity related to component cognitive processes. This training will build on Dr. Albert’s prior experience in human cognitive neuroscience using functional neuroimaging to examine the neurobiology of cognitive aging. Research Project: These career goals will be facilitated through a research study focused on the role of cholinergic support of attention as a cognitive compensatory mechanism in SCD. As early AD-related neuropathology affects medial temporal areas important for memory, there may be a compensatory enhancement of attention network activity via increased cholinergic function. Although memory performance is maintained through this compensatory process, subtle cognitive changes may be obscured. Additionally, the individual may experience this change as increased required effort or occasional memory failures which result in subjective cognitive decline despite normal cognitive testing. Cholinergic activity may be an integral component of maintaining memory function in early AD, through enhanced attention. The proposed study focuses on attention as a compensatory cognitive process and the relationships between AD-related pathology and cholinergic neurotransmitter mechanisms that may underlie this compensation in SCD. The ultimate aim of the study is to identify the role of attention network changes in supporting cognitive performance in SCD using EEG and fMRI as complimentary neuroimaging approaches. Anticholinergic challenge will be employed to model AD progression and examine the relationships between cognitive concerns, attention, and AD pathology. The results of this study will improve our understanding of brain changes that maintain cognitive performance in the early stages of AD pathology and may underlie SCD. Environment: Mentoring, collaborations, and resources available through the Department of Psychiatry and Behavioral Sciences, the Center for Cognitive Medicine, and the Vanderbilt Alzheimer’s Disease Research Center provide an ideal environment to support Dr. Albert’s transition to independent funding and leadership in the field of attentional changes in cognitive aging.

主观认知下降和AD风险中认知补偿的注意机制 候选人：金伯利·阿尔伯特（Kimberly Albert）博士是精神病学系的助理教授 范德比尔特大学医学中心的科学，在认知和系统方面具有良好的背景 神经科学。她的长期职业目标包括获得必要的培训以成为独立 研究人员的研究重点是识别早期维持认知功能的大脑机制 病理大脑衰老的阶段，可能是主观认知能力下降（SCD）的基础。 职业发展：阿尔伯特博士试图将她的机械工作转化为临床研究，以减轻 早期AD病理学的认知作用。阿尔伯特博士需要在1）临床试验开发中进行高级培训， 实施和管理。 2）SCD和阿尔茨海默氏症的临床表现，课程和评估 疾病; 3）使用EEG/ERP神经影像学提供临时分辨率，以评估与 组成认知过程。这项培训将以阿尔伯特博士在人类认知的先前经验为基础 使用功能性神经影像学检查认知衰老的神经生物学。 研究项目：这些职业目标将通过重点介绍的研究来准备 胆碱能注意力作为SCD中的认知补偿机制。作为早期广告相关的 神经病理学影响内侧临时区域对记忆很重要，可能会有补偿性 通过增加的胆碱能功能增强注意力网络活性。虽然记忆性能是 通过这种补偿过程维持，可能会掩盖微妙的认知变化。另外， 个人可能会遇到这种变化，因为需要增加所需的努力或偶尔的记忆失败 在主观认知下降偏好中，正常认知测试。胆碱能活性可能是不可或缺的 通过增强的注意力，在AD早期维持内存功能的组成部分。 拟议的研究将注意力集中在补偿性认知过程中以及 广告相关的病理学和胆碱能神经递质机制，可能是SCD中这种补偿的基础。 该研究的最终目的是确定注意网络变化在支持认知方面的作用 使用EEG和fMRI作为免费的神经影像学方法，在SCD中的性能。抗胆碱能 挑战将被雇用以建模广告进展并检查认知问题之间的关系， 注意和广告病理学。这项研究的结果将改善我们对大脑变化的理解 在AD病理学的早期阶段保持认知表现，并可能是SCD的基础。 环境：通过精神病学系获得的指导，合作和资源 行为科学，认知医学中心和范德比尔特阿尔茨海默氏病研究 中心提供了一个理想的环境，以支持阿尔伯特博士向独立资金和领导的过渡 认知衰老的注意力变化领域。