Boston Area Diabetes and Endocrinology Research Center (BADERC)

波士顿地区糖尿病和内分泌研究中心 (BADERC)

• 批准号: 10586200
• 负责人: ALEXANDER A SOUKAS
• 金额: $ 109.07万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-15 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10586200
• 关键词: Academic Medical Centers; Academic support; Address; Area; Autoimmunity; Bioinformatics; Blood Vessels; Boston; Cellular biology; Clinical; Clinical Investigator; Collaborations; Communication; Communities; Dana-Farber Cancer Institute; Development; Diabetes Mellitus; Direct Costs; Education; Endocrinology; Ensure; Etiology; Fostering; General Hospitals; Genes; Genomics; Graft Rejection; Grant; Hospitals; Image; Immunologics; Institution; Insulin; Insulin Resistance; International; Israel; Knowledge; Laboratories; Massachusetts; Medical Students; Medical center; Metabolic; Methods; Molecular; Molecular Genetics; Monitor; Neurobiology; New England; Pathogenesis; Patient Care; Pediatric Hospitals; Physiology; Productivity; Proteomics; Public Health Schools; Research; Research Institute; Research Personnel; Resources; Scientist; Services; Talents; Teaching Hospitals; Training; Transgenic Animals; Translational Research; Update; Woman; clinical investigation; cost effective; energy balance; experience; genetic architecture; inter-institutional; macrovascular disease; medical schools; metabolomics; multidisciplinary; optimal treatments; programs; repository; training opportunity; trait; type I and type II diabetes; web site

ABSTRACT The Boston Area Diabetes Endocrinology Research Center (BADERC) is a consortium of laboratory-based and clinical investigators whose efforts are directed toward addressing the major research questions bearing on the etiology, pathogenesis, treatment and cure of type 1 and type 2 diabetes, and their associated microvascular and macrovascular complications. The Center Director (Jose Florez) and Associate Directors (Barbara Kahn and Alexander Soukas) are highly productive senior investigators of international stature. The 64 participating scientists, with combined annual direct costs in excess of $110M in diabetes-related grant support, are based at various Boston-area research institutions, including the major Harvard Medical School-affiliated teaching hospitals (the Massachusetts General Hospital, the Beth Israel Deaconess Medical Center, the Brigham and Women's Hospital, Boston Children’s Hospital) and research institutes (the School of Public Health, Dana-Farber Cancer Institute, the Broad Institute), the Boston University Medical Center, and the Tufts New England Medical Center. These investigators are working at the cutting edge of fields most relevant to defining the pathogenesis and optimal treatment of type 1 and type 2 diabetes, such as 1) the molecular basis of insulin action and insulin resistance; 2) the neurobiology of energy balance; 3) the immunologic basis and optimal therapies for autoimmunity and transplant rejection; 4) the genetic architecture of diabetes and related traits; and 5) the development of new methods for glycemic monitoring and control. The BADERC offers these scientists an Enrichment Program and an array of core support services (Cell Biology, Transgenic Animals, Metabolic Physiology) that incorporate the latest technical advances in molecular genetics, cell biology, and metabolic physiology provided by acknowledged experts and provide hands-on training. New Cores in Clinical Investigation and Bioinformatics are proposed in this application. BADERC investigators also receive facilitated access to several platforms of the Broad Institute (Genomics, Proteomics, Metabolomics, Imaging, Gene editing). The BADERC also offers a highly subscribed and successful Pilot & Feasibility grant program, and BADERC investigators support summer medical students for a research experience. The easy access to cost-effective support services of outstanding quality, together with the educational and pilot grants program, have promoted many collaborations, and attracted new talent from this outstanding scientific community to diabetes research. Finally, the Center strives to foster the closest interactions between the laboratory based and clinical scientists, so as to ensure the translation of research discoveries into advances in the care of patients with diabetes.

抽象的 波士顿地区糖尿病内分泌研究中心（BADERC）是 基于实验室和临床研究人员的努力是针对针对主要的 有关1型和类型的病因，发病机理，治疗和治疗的研究问题 2种糖尿病及其相关的微血管和大血管并发症。中心 导演（何塞·弗洛雷斯（Jose Florez））和副总监（芭芭拉·卡恩（Barbara Kahn）和亚历山大·索卡斯（Alexander Soukas）） 国际地位的高级高级调查员。 64位参与科学家， 每年的直接成本超过1.1亿美元的糖尿病相关赠款支持，基于 波士顿地区的各种研究机构，包括哈佛大学的主要伴随 教学医院（马萨诸塞州综合医院，贝丝以色列执事医疗 中心，波士顿儿童医院的杨树和妇女医院）和研究机构 （Broad Institute Dana-Farber癌症研究所公共卫生学院），波士顿 大学医学中心和塔夫特新英格兰医疗中心。这些调查人员是 在与定义发病机理最相关的田野的最前沿工作 1型和2型糖尿病的治疗，例如1）胰岛素作用和 胰岛素抵抗； 2）能量平衡的神经生物学； 3）免疫基础和最佳基础 自身免疫和移植排斥的疗法； 4）糖尿病和 相关特征； 5）开发用于血糖监测和控制的新方法。这 Baderc为这些科学家提供了一个丰富计划和一系列核心支持服务 （细胞生物学，转基因动物，代谢生理），结合了最新的技术 分子遗传学，细胞生物学和代谢生理学的进步 认可专家并提供动手培训。临床研究中的新核心 在本应用程序中提出了生物信息学。 Baderc调查人员还收到了准备 访问广泛研究所的多个平台（基因组学，蛋白质组学，代谢组学，， 成像，基因编辑）。 Baderc还提供了高度订阅且成功的飞行员 可行性赠款计划，BADERC调查人员支持夏季医学生 研究经验。轻松获得具有卓越质量的具有成本效益的支持服务， 与教育和试点赠款计划一起促进了许多合作，并 从这个杰出的科学界吸引了新的人才到糖尿病研究。最后， 中心努力促进基于实验室和临床之间的最接近的相互作用 科学家，以确保将研究发现转化为护理的进步 糖尿病患者。