Boston Area Diabetes and Endocrinology Research Center (BADERC)

波士顿地区糖尿病和内分泌研究中心 (BADERC)

• 批准号: 10586200
• 负责人: ALEXANDER A SOUKAS
• 金额: $ 109.07万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-15 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10586200
• 关键词: Academic Medical Centers; Academic support; Address; Area; Autoimmunity; Bioinformatics; Blood Vessels; Boston; Cellular biology; Clinical; Clinical Investigator; Collaborations; Communication; Communities; Dana-Farber Cancer Institute; Development; Diabetes Mellitus; Direct Costs; Education; Endocrinology; Ensure; Etiology; Fostering; General Hospitals; Genes; Genomics; Graft Rejection; Grant; Hospitals; Image; Immunologics; Institution; Insulin; Insulin Resistance; International; Israel; Knowledge; Laboratories; Massachusetts; Medical Students; Medical center; Metabolic; Methods; Molecular; Molecular Genetics; Monitor; Neurobiology; New England; Pathogenesis; Patient Care; Pediatric Hospitals; Physiology; Productivity; Proteomics; Public Health Schools; Research; Research Institute; Research Personnel; Resources; Scientist; Services; Talents; Teaching Hospitals; Training; Transgenic Animals; Translational Research; Update; Woman; clinical investigation; cost effective; energy balance; experience; genetic architecture; inter-institutional; macrovascular disease; medical schools; metabolomics; multidisciplinary; optimal treatments; programs; repository; training opportunity; trait; type I and type II diabetes; web site

ABSTRACT The Boston Area Diabetes Endocrinology Research Center (BADERC) is a consortium of laboratory-based and clinical investigators whose efforts are directed toward addressing the major research questions bearing on the etiology, pathogenesis, treatment and cure of type 1 and type 2 diabetes, and their associated microvascular and macrovascular complications. The Center Director (Jose Florez) and Associate Directors (Barbara Kahn and Alexander Soukas) are highly productive senior investigators of international stature. The 64 participating scientists, with combined annual direct costs in excess of $110M in diabetes-related grant support, are based at various Boston-area research institutions, including the major Harvard Medical School-affiliated teaching hospitals (the Massachusetts General Hospital, the Beth Israel Deaconess Medical Center, the Brigham and Women's Hospital, Boston Children’s Hospital) and research institutes (the School of Public Health, Dana-Farber Cancer Institute, the Broad Institute), the Boston University Medical Center, and the Tufts New England Medical Center. These investigators are working at the cutting edge of fields most relevant to defining the pathogenesis and optimal treatment of type 1 and type 2 diabetes, such as 1) the molecular basis of insulin action and insulin resistance; 2) the neurobiology of energy balance; 3) the immunologic basis and optimal therapies for autoimmunity and transplant rejection; 4) the genetic architecture of diabetes and related traits; and 5) the development of new methods for glycemic monitoring and control. The BADERC offers these scientists an Enrichment Program and an array of core support services (Cell Biology, Transgenic Animals, Metabolic Physiology) that incorporate the latest technical advances in molecular genetics, cell biology, and metabolic physiology provided by acknowledged experts and provide hands-on training. New Cores in Clinical Investigation and Bioinformatics are proposed in this application. BADERC investigators also receive facilitated access to several platforms of the Broad Institute (Genomics, Proteomics, Metabolomics, Imaging, Gene editing). The BADERC also offers a highly subscribed and successful Pilot & Feasibility grant program, and BADERC investigators support summer medical students for a research experience. The easy access to cost-effective support services of outstanding quality, together with the educational and pilot grants program, have promoted many collaborations, and attracted new talent from this outstanding scientific community to diabetes research. Finally, the Center strives to foster the closest interactions between the laboratory based and clinical scientists, so as to ensure the translation of research discoveries into advances in the care of patients with diabetes.

抽象的 波士顿地区糖尿病内分泌学研究中心 (BADERC) 是一个财团 基于实验室和临床的研究人员，其努力旨在解决主要问题 有关1型和2型的病因、发病机制、治疗和治愈的研究问题 2 糖尿病及其相关的微血管和大血管并发症。 董事（Jose Florez）和副董事（Barbara Kahn 和 Alexander Soukas）高度评价 64 名具有国际地位的富有成效的高级研究人员， 与糖尿病相关的赠款支持的年度直接成本合计超过 1.1 亿美元，计算公式为 波士顿地区的各个研究机构，包括哈佛医学院附属的主要研究机构 教学医院（马萨诸塞州总医院、贝斯以色列女执事医疗中心 中心、布莱根妇女医院、波士顿儿童医院）和研究机构 （公共卫生学院、达纳法伯癌症研究所、布罗德研究所）、波士顿 大学医学中心和塔夫茨新英格兰医学中心这些研究人员是。 工作在与确定发病机制和优化最相关的领域的前沿 1 型和 2 型糖尿病的治疗，例如 1) 胰岛素作用的分子基础和 胰岛素抵抗；2）能量平衡的神经生物学；3）免疫学基础和优化 自身免疫和移植排斥的治疗；4) 糖尿病的遗传结构和 相关性状；5）开发血糖监测和控制的新方法。 BADERC 为这些科学家提供丰富计划和一系列核心支持服务 （细胞生物学、转基因动物、代谢生理学）融合了最新技术 分子遗传学、细胞生物学和代谢生理学的进展 公认的专家并提供临床研究和新核心的实践培训。 BADERC 研究人员也在此申请中提出了生物信息学的建议。 访问布罗德研究所的多个平台（基因组学、蛋白质组学、代谢组学、 BADERC 还提供了高度订阅和成功的试点项目。 可行性资助计划和 BADERC 调查人员支持暑期医学生 研究经验。轻松获得具有成本效益的优质支持服务， 与教育和试点赠款计划一起促进了许多合作，并且 吸引了来自这个杰出科学界的新人才参与糖尿病研究。 中心致力于促进实验室与临床之间最密切的互动 科学家，以确保将研究发现转化为护理方面的进步 糖尿病患者。