Functional Neuroimaging of the Nonhuman Primate Social Brain

非人类灵长类动物社交大脑的功能神经影像

基本信息

批准号：
7677814
负责人：
CHRISTOPHER J MACHADO
金额：
$ 9万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-08-21 至 2011-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7677814
关键词：
Address Adult Affect Amygdaloid structure Animal Experiments Animals Anogenital region Anterior Anxiety Anxiety Disorders Area Autistic Disorder Behavior Behavioral Biological Neural Networks Brain Brain region Categories Cerebrum Chronic Data Etiology Exhibits Eye Female Funding Glucose Goals Human Image Implanted Electrodes Inferior Infusion procedures Intelligence Juice Learning Lesion Macaca Macaca mulatta Measures Mediating Mental disorders Metabolic Metabolism Methods Monkeys Mothers Motivation Nurseries Perception Personality Phase Positron-Emission Tomography Process Public Health Recording of previous events Relative (related person)Research Personnel Resolution Rewards Scanning Series Signal Transduction Social Behavior Social Interaction Social Perception Stimulus Structure Structure of superior temporal sulcus Swelling System Techniques Temporal Lobe Training Visual Perception Visual attention behavior test brain metabolism cingulate cortex cohort depression effective therapy glucose metabolism male mature animal neuroimaging nonhuman primate pressure programs radiotracer relating to nervous system skills social social cognition visual information

项目摘要

DESCRIPTION (provided by applicant): Deficits in social cognition characterize many human psychiatric disorders, but the neural substrates of such deficits remain largely unknown. In fact, there is little certainty about the neural systems that normally subserve social cognition. This deficiency is largely due to the use of invasive methods and a lack of standardized behavioral testing paradigms that probe components of social cognition, such as social perception and social motivation. During the proposed funding period, I will obtain additional training and expertise by addressing these deficits. During the K99 phase, I will measure cerebral glucose metabolism, a correlate of neural activity, using high-resolution positron emission tomography (microPET). Two video presentations will be created; one depicting a variety of social interactions and the other with no social content. MicroPET data will be acquired after subjects view each video to identify neural regions preferentially engaged during the perception of visual social signals. A second study will investigate the neural correlates of social motivation. Some adult animals typically forego juice rewards to view pictures of salient social signals (i.e., female sexual swellings), but not to view pictures of lower-ranked animals or objects. Comparison of microPET data acquired after each of these three conditions will identify brain regions involved in directing behavior towards socially relevant information. Both studies will use noninvasive eye tracking techniques to measure visual attention to videos or choices of social pictures versus juice rewards. In the subsequent ROO phase, I will implement the skills and behavioral tasks developed during the K99 phase to investigate how cerebral metabolism differs in subjects raised under atypical conditions (i.e., nursery-reared) or for animals that exhibit maladaptive social behavior. Relevance to Public Health: Social behavior deficits are prevalent in many human psychiatric disorders, such as autism, social anxiety disorder and depression. However, effective treatments remain elusive because little is known about how the normal brain processes social information and selects appropriate social behaviors. The goal of these studies is to develop new, noninvasive methods for identifying: brain areas subserving these abilities.

描述（由申请人提供）：社会认知缺陷是许多人类精神疾病的特征，但这种缺陷的神经基础仍然很大程度上未知。事实上，通常促进社会认知的神经系统几乎没有确定性。这种缺陷很大程度上是由于侵入性方法的使用以及缺乏探究社会认知组成部分（例如社会感知和社会动机）的标准化行为测试范式。在拟议的资助期内，我将通过解决这些赤字来获得额外的培训和专业知识。在 K99 阶段，我将使用高分辨率正电子发射断层扫描 (microPET) 测量大脑葡萄糖代谢（与神经活动相关）。将创建两个视频演示；一个描述了各种社交互动，另一个则没有社交内容。受试者观看每个视频后将获取 MicroPET 数据，以识别在视觉社交信号感知过程中优先参与的神经区域。第二项研究将调查社会动机的神经相关性。一些成年动物通常会放弃果汁奖励来观看显着社交信号（即雌性性肿胀）的图片，但不会观看排名较低的动物或物体的图片。比较这三种情况后获取的 microPET 数据将识别涉及将行为引导至社会相关信息的大脑区域。这两项研究都将使用非侵入性眼球追踪技术来衡量对视频的视觉注意力或社交图片的选择与果汁奖励的比较。在随后的 ROO 阶段，我将实施 K99 阶段开发的技能和行为任务，以研究在非典型条件（即托儿所饲养）下饲养的受试者或表现出适应不良社会行为的动物的大脑代谢有何不同。与公共卫生的相关性：社会行为缺陷在许多人类精神疾病中普遍存在，例如自闭症、社交焦虑症和抑郁症。然而，有效的治疗方法仍然难以捉摸，因为人们对正常大脑如何处理社交信息并选择适当的社交行为知之甚少。这些研究的目标是开发新的非侵入性方法来识别：促进这些能力的大脑区域。

项目成果

期刊论文数量（1）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Monkey visual attention does not fall into the uncanny valley.

猴子的视觉注意力不会落入恐怖谷。

DOI：
发表时间：
2022-07-11
期刊：
影响因子：
4.6
作者：
Carp, Sarah B;Santistevan, Anthony C;Machado, Christopher J;Whitaker, Alexander M;Aguilar, Brittany L;Bliss
通讯作者：
Bliss