Neurobiology of primate social and emotional behavior

灵长类动物社会和情感行为的神经生物学

• 批准号: 6340228
• 负责人: CHRISTOPHER J MACHADO
• 金额: $ 2.51万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6340228
• 关键词: Macaca mulatta; amygdala; behavior test; behavioral /social science research tag; emotions; ethology; frontal lobe /cortex; hippocampus; magnetic resonance imaging; mind control; neurobiology; social adjustment; social behavior; social group process; social perception; social psychology; stereotaxic techniques; visual stimulus

Neuroanatomical, electrophysiological, functional imaging and lesion data indicate that the amygdala, hippocampus and orbital frontal cortex contribute to primate social and emotional behaviors. However, due primarily to past methodological deficiencies, the involvement and specific contributions of these brain regions in a circuit responsible for adaptive social behavior and emotional expression are still a matter for debate. The research program described in this proposal will rectify some of these deficiencies by combining ethologically-valid behavioral observations, semi-naturalistic testing environments and precise lesioning techniques to investigate two specific aims. First, the specific contributions of the amygdala, hippocampus and orbital frontal cortex to emotional reactivity in rhesus monkeys (Macaca mulatta) will be studied using three paradigms, each displaying a different visual stimulus in distinct environments. Second, the contributions of these neural regions to group social interactions will be studied in the same subjects. Social skills will be examined while four individuals interact in a large enclosure and social variables, such as group membership and size, will be systematically manipulated and controlled. The results generated from these two investigations will provide a new and sophisticated understanding of how the primate brain uses emotion to modulate social behavior adaptively.

神经解剖学、电生理学、功能成像和病变数据表明，杏仁核、海马体和眶额皮质有助于灵长类动物的社交和情感行为。然而，主要由于过去方法上的缺陷，这些大脑区域在负责适应性社会行为和情绪表达的回路中的参与和具体贡献仍然是一个有争议的问题。该提案中描述的研究计划将通过结合行为学上有效的行为观察、半自然测试环境和精确的损伤技术来纠正其中一些缺陷，以研究两个特定目标。首先，将使用三种范式研究杏仁核、海马体和眶额皮质对恒河猴（Macaca mulatta）情绪反应的具体贡献，每种范式在不同的环境中显示不同的视觉刺激。其次，将在同一受试者中研究这些神经区域对群体社会互动的贡献。当四个人在一个大的封闭空间中互动时，将检查社交技能，并且将系统地操纵和控制群体成员和规模等社会变量。这两项研究产生的结果将为灵长类动物大脑如何利用情绪适应性地调节社会行为提供新的、复杂的理解。