NON-INVASIVE ACTIVATION IMAGING OF THE NON-HUMAN PRIMATE BRAIN USING MICROPET

使用微型宠物对非人类灵长类动物大脑进行非侵入性激活成像

• 批准号: 8357319
• 负责人: CHRISTOPHER J MACHADO
• 金额: $ 10.1万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357319
• 关键词: Address; Animals; Brain; California; Funding; Grant; Head; Human; Image; Injection of therapeutic agent; Macaca; Methods; Motor; National Center for Research Resources; Positron-Emission Tomography; Primates; Principal Investigator; Procedures; Protocols documentation; Research; Research Infrastructure; Resources; Scanning; Sensory; Source; Stress; United States National Institutes of Health; awake; cost; neuroimaging; nonhuman primate; radiotracer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Controlled methods for "activation" neuroimaging comparable to human PET studies have not yet been developed for awake, behaving macaques. These studies will address this issue. With simple sensory and motor protocols, we will develop methods for 1) the systematic habituation of animals to handling procedures, 2) administering the microPET radiotracer without the animal being aware, thereby mitigating the effects of injection-related stress, and 3) standardizing head placement inside the microPET scanner across multiple scan dates.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 对于清醒、有行为能力的猕猴，尚未开发出可与人类 PET 研究相媲美的“激活”神经影像学受控方法。 这些研究将解决这个问题。 通过简单的感觉和运动方案，我们将开发以下方法：1）使动物系统地习惯处理程序，2）在动物不知情的情况下使用 microPET 放射性示踪剂，从而减轻注射相关压力的影响，以及 3）标准化头部跨多个扫描日期放置在 microPET 扫描仪内。