SYNAPTIC PLASTICITY AND EXTINCTION OF FEAR

突触可塑性和恐惧的消除

• 批准号: 7562667
• 负责人: Kerry J Ressler
• 金额: $ 2.37万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562667
• 关键词: Amygdaloid structure; Behavioral; Behavioral Genetics; Computer Retrieval of Information on Scientific Projects Database; Extinction (Psychology); Fright; Funding; Grant; Institution; Memory; Molecular; Mus; Recombinants; Research; Research Personnel; Resources; Role; Source; Synaptic plasticity; Technology; Training; United States National Institutes of Health; Work; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project allowed us to combine the work of mouse behavioral genetics, recombinant lentiviral technology and mouse behavioral studies for further work in the molecular mechanisms of amygdala functioning, synaptic plasticity, and the extinction of fear memories. We have completed the training aims of this project which were to optimize the molecular tools available to understand the role of the amygdala in the acquisition and extinction of fear.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该项目使我们能够将小鼠行为遗传学、重组慢病毒技术和小鼠行为研究的工作结合起来，进一步研究杏仁核功能、突触可塑性和恐惧记忆消除的分子机制。 我们已经完成了该项目的培训目标，即优化可用的分子工具，以了解杏仁核在恐惧的获得和消除中的作用。