FEAR LEARNING IN MICE AND DISORDERS OF FEAR IN HUMANS

小鼠的恐惧学习和人类的恐惧障碍

• 批准号: 7562647
• 负责人: Kerry J Ressler
• 金额: $ 3.16万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562647
• 关键词: Behavior; Clinical Treatment; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Cycloserine; Disease; Fright; Funding; Genetic; Goals; Grant; Human; Institution; Learning; Molecular; Mus; N-Methyl-D-Aspartate Receptors; N-Methylaspartate; Post-Traumatic Stress Disorders; Receptor Gene; Reporting; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Woman; base; learning extinction; mouse model

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this project is to examine the molecular mechanisms of fear learning and extinction in genetic mouse models, to examine the genetics of PTSD, particularly focusing on the NMDA receptor genes in humans, and to perform a clinical trial for treatment of PTSD in traumatized women using D-cycloserine to enhance the NMDA-dependent learning underlying behavior-based exposure therapy. During the reporting period, we've begun to further examine NMDA function in mouse through the use of a 'floxed' inducible deletion NMDA receptor subunit 1 mouse line.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该项目的目标是研究遗传小鼠模型中恐惧学习和消退的分子机制，研究 PTSD 的遗传学，特别关注人类的 NMDA 受体基因，并进行创伤后应激障碍治疗的临床试验。女性使用 D-环丝氨酸来增强基于行为暴露疗法的 NMDA 依赖性学习。 在报告期内，我们开始通过使用“floxed”诱导性缺失 NMDA 受体亚基 1 小鼠品系进一步检查小鼠中的 NMDA 功能。