THE ROLE OF NEUREGULIN AND ITS RECEPTOR, ERBB4, IN CONDITIONED FEAR LEARNING

神经调节蛋白及其受体 ERBB4 在条件恐惧学习中的作用

• 批准号: 7562620
• 负责人: Kerry J Ressler
• 金额: $ 3.16万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562620
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Dominant-Negative Mutation; ErbB4 gene; Funding; Grant; Institution; Learning; Ligands; Mediation; Neuregulins; Reporting; Research; Research Personnel; Resources; Role; Source; Subfamily lentivirinae; Testing; Transgenic Mice; United States National Institutes of Health; conditioned fear; novel strategies; receptor; virus Cre recombinase

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal combines novel approaches to studying the role of ErbB4 receptor and its ligand, neuregulin, in the mediation of conditioned fear learning. Progress during this reporting period includes optimization and testing of a dominant-negative ErbB4 expressing lentivirus, and a cre-recombinase virus to use in combination with 'floxed' neuregulin transgenic mouse.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该提案结合了研究 ErbB4 受体及其配体神经调节蛋白在调节条件恐惧学习中的作用的新方法。 本报告期内取得的进展包括优化和测试表达显性失活 ErbB4 的慢病毒，以及与“floxed”神经调节蛋白转基因小鼠结合使用的 cre 重组酶病毒。