GENETIC AND TRAUMA-RELATED RISK FACTORS FOR PTSD

创伤后应激障碍的遗传和创伤相关风险因素

• 批准号: 7562648
• 负责人: Kerry J Ressler
• 金额: $ 2.37万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562648
• 关键词: Adult; Affective; Alleles; Brain-Derived Neurotrophic Factor; Child Abuse; Computer Retrieval of Information on Scientific Projects Database; Environment; Frequencies; Funding; Genes; Genetic; Goals; Grant; Haplotypes; Hospitals; Institution; Mediating; Mediator of activation protein; Mental Depression; Phenotype; Population; Post-Traumatic Stress Disorders; Reporting; Research; Research Infrastructure; Research Personnel; Resources; Risk; Risk Factors; Salivary; Sampling; Source; Symptoms; Trauma; United States National Institutes of Health; early childhood; inner city; psychologic

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goals of this project are to first develop an infrastructure for doing large scale genetic and psychological studies of trauma-related and affective psychiatric illness in the general non-psychiatric population at Grady Hospital, serving the inner-city in Atlanta. The primary aims are to examine the 5HTTLPR and BDNF (Val66Met) alleles as mediators of trauma in the risk for PTSD as well as to examine the frequencies of other psychiatrically related haplotypes in this population. During the reporting period we have obtained samples from over 600 subjects including salivary dna and detailed phenotype information related to abuse, trauma, depression, and ptsd symptoms. The principal findings detail gene x environment interactions mediating the effects of early childhood abuse on adult depression and of early childhood abuse on PTSD in traumatized adults.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该项目的目标是首先开发一个基础设施，用于在格雷迪医院对一般非精神病人群的创伤相关和情感精神疾病进行大规模遗传和心理研究，为亚特兰大市中心提供服务。 主要目的是检查 5HTTLPR 和 BDNF (Val66Met) 等位基因作为创伤后应激障碍 (PTSD) 风险的中介因素，并检查该人群中其他精神科相关单倍型的频率。 在报告期内，我们获得了 600 多名受试者的样本，包括唾液 DNA 以及与虐待、创伤、抑郁和创伤后应激障碍 (PTSD) 症状相关的详细表型信息。 主要发现详细说明了基因与环境的相互作用，介导了儿童早期虐待对成人抑郁症的影响，以及儿童早期虐待对受创伤成人的创伤后应激障碍（PTSD）的影响。