AMYGDALA VS HIPPOCAMPAL BDNF FUNCTION WITH MOLECULAR GENETIC TECHNIQUES

杏仁核与海马 BDNF 功能与分子遗传技术

• 批准号: 7562621
• 负责人: Kerry J Ressler
• 金额: $ 3.16万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562621
• 关键词: Amygdaloid structure; BDNF gene; Computer Retrieval of Information on Scientific Projects Database; Extinction (Psychology); Fright; Funding; Genetic Techniques; Grant; Hippocampus (Brain); Institution; Lentivirus Vector; Molecular Genetics; Paper; Publishing; Reporting; Research; Research Personnel; Resources; Site; Source; Transgenic Mice; United States National Institutes of Health; novel; recombinase

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal combined a novel lentivirus vector that expresses the Cre recombinase with transgenic mice in which the BDNF gene has been flanked by LoxP sites (Floxed). During the reporting period, we have published three papers related to this topic. We found that hippocampal bdnf and trkB activation within the amygdala are required for the normal extinction of fear.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该提案将表达 Cre 重组酶的新型慢病毒载体与 BDNF 基因侧翼为 LoxP 位点 (Floxed) 的转基因小鼠结合起​​来。 报告期内，我们共发表了三篇与该主题相关的论文。 我们发现杏仁核内的海马 bdnf 和 trkB 激活是正常消除恐惧所必需的。