Exercise adherence and cognitive decline: Engaging with the Black community to develop and test a goal-setting and exercise intensity intervention

运动坚持和认知能力下降：与黑人社区合作制定和测试目标设定和运动强度干预措施

• 批准号: 10767102
• 负责人: Angela Bryan
• 金额: $ 37.94万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-18 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10767102
• 关键词: Adherence; Adopted; Adult; Affect; Affective; African American; African American population; Age; Age-associated memory impairment; Aging; Alleles; Alzheimer' s Disease; Alzheimer' s disease related dementia; American; Amyloid beta-Protein; Apolipoprotein E; Area; Awareness; Behavior; Benchmarking; Biological; Biological Markers; Black American; Black race; Cardiovascular Diseases; Chronic Disease; Code; Collaborations; Communities; Data; Demographic Factors; Development; Diabetes Mellitus; Disparity; Effectiveness; Effectiveness of Interventions; Equity; Ethnic Origin; Exercise; Feedback; Genes; Genetic; Genotype; Goals; Guidelines; Health; Health behavior and outcomes; Immigrant; Immigrant community; Impaired cognition; Individual; Intervention; Intervention Trial; Life Style; Light; Literature; Maintenance; Measures; Mediating; Mediator; Meta-Analysis; Methods; Moderate Exercise; Morbidity - disease rate; Not Hispanic or Latino; Outcome; Participant; Persons; Phase; Physical activity; Plasma; Population; Prevalence; Prevention; Process; Public Health; Race; Recommendation; Reporting; Research; Research Design; Risk; Sampling; Self Efficacy; Strenuous Exercise; Structural Racism; System; Techniques; Testing; Translating; Treatment Efficacy; Underrepresented Populations; Vascular Dementia; Vulnerable Populations; Work; World Health Organization; acceptability and feasibility; behavioral adherence; community engaged research; design; economic cost; efficacy testing; exercise adherence; exercise intensity; exercise intervention; exercise regimen; feasibility trial; health disparity; human old age (65+); hyperphosphorylated tau; intervention effect; intrinsic motivation; meetings; member; metropolitan; mild cognitive impairment; moderate-to-vigorous physical activity; mortality; neglect; neurofilament; people of color; person centered; pilot trial; psychologic; randomized trial; recruit; response; risk mitigation; socioeconomics; tau Proteins; tau-1; theories; vigorous intensity

Project Summary The average age of the U.S. population is rapidly increasing and with it the prevalence of age-associated cognitive decline. Furthermore, the risk for age-associated cognitive decline may disproportionately affect many historically underrepresented groups. Regular physical activity (PA) is associated with lower risk for cognitive decline, but many people struggle to maintain PA over the long term. Goal setting presents one promising avenue to facilitate PA maintenance and has strong public health significance. Likewise, exercise intensity may further this aim as challenging goals for higher intensity PA may provide the most robust PA maintenance. Importantly, however, most existing research on goal setting, exercise intensity, and theory- based exercise interventions overall has been generated among high SES, low diversity samples, and the field has largely neglected this disparity, with recent reviews and meta-analyses failing to even report racial, ethnic, or socioeconomic demographic factors. While systems of oppression and structural racism undoubtedly influence disparities in health behavior and outcomes, it is also possible that existing individual-level theory- based interventions are not culturally appropriate for many communities, such as African Americans and Black immigrants (i.e., the Black community). In this application, we will take a community engaged research approach to tailor and test a theory-based intervention promoting adherence to recommended levels of PA in the Black community using the technique of person-centered goal setting. We will determine whether prescriptions of different PA intensities moderate the effectiveness of these goal-setting approaches and test the theoretical mediators associated with the effectiveness of these interventions on behavioral adherence and healthy changes in biomarkers associated with cognitive decline. Therefore, the overarching goals of this project are to take a community engaged research approach to 1) tailor a theory-based goal-setting exercise intervention in the Denver metropolitan area Black community (R61) and 2) utilize the Operating Conditions Framework to test the efficacy of the intervention for PA adherence, weekly volume of exercise, and changes in biomarkers associated with cognitive decline (R33). These objectives will be met through collaboration with our community partner The Gyedi Project to focus on and fully engage the Black community in the Denver metropolitan area in the research process.

项目概要 美国人口的平均年龄正在迅速增加，随之而来的是与年龄相关的疾病的流行 认知能力下降。此外，与年龄相关的认知能力下降的风险可能会不成比例地影响 许多历史上代表性不足的群体。定期进行体力活动 (PA) 与较低的风险相关 认知能力下降，但许多人很难长期维持 PA。目标设定提出了一种 促进 PA 维护的有希望的途径，并且具有很强的公共卫生意义。同样，锻炼身体 强度可能会进一步实现这一目标，因为更高强度 PA 的挑战性目标可能会提供最稳健的 PA 维护。然而，重要的是，大多数现有的关于目标设定、运动强度和理论的研究—— 基于运动的干预措施总体上是在高社会经济地位、低多样性样本和现场中产生的 在很大程度上忽视了这种差异，最近的评论和荟萃分析甚至没有报告种族、民族、 或社会经济人口因素。虽然压迫制度和结构性种族主义无疑 影响健康行为和结果的差异，现有的个人层面的理论也有可能 基于文化的干预措施在文化上不适合许多社区，例如非裔美国人和黑人 移民（即黑人社区）。在此应用程序中，我们将进行社区参与的研究 定制和测试基于理论的干预措施的方法，促进坚持建议的 PA 水平 黑人社区使用以人为本的目标设定技术。我们将确定是否 不同 PA 强度的处方会调节这些目标设定方法和测试的有效性 与这些干预措施对行为依从性的有效性相关的理论中介因素 与认知能力下降相关的生物标志物的健康变化。因此，本次会议的总体目标 项目将采用社区参与的研究方法来 1）定制基于理论的目标设定 丹佛大都市区黑人社区 (R61) 的运动干预和 2) 利用 每周测试 PA 依从性干预措施效果的操作条件框架 运动量以及与认知能力下降相关的生物标志物的变化（R33）。这些 将通过与我们的社区合作伙伴 Gyedi 项目的合作来实现目标，重点关注并充分 让丹佛大都市区的黑人社区参与研究过程。