Developing a culturally tailored mHealth symptom monitoring intervention to improve adherence to endocrine therapy among Black women with breast cancer

开发适合文化的移动健康症状监测干预措施，以提高患有乳腺癌的黑人女性对内分泌治疗的依从性

• 批准号: 10642274
• 负责人: Kimberley T Lee
• 金额: $ 28.46万
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-18 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10642274
• 关键词: Address; Adherence; Behavior Therapy; Biological; Black Populations; Black race; Breast Cancer survivor; Cancer Center; Cancer Survivor; Cancer Survivorship; Caring; Cessation of life; Clinical; Clinical Research; Comprehension; Consent; Control Groups; Data; Daughter; Department chair; Development; Development Plans; Discipline; Disparity; Educational Materials; Educational workshop; Eligibility Determination; Encapsulated; Ensure; Environment; Epidemiologic Methods; Epidemiology; Feedback; Foundations; Funding; Future; Goals; Health Technology; High Risk Woman; Institution; Intervention; Interview; Life; Malignant Neoplasms; Measures; Mentorship; Methods; Minority; Modeling; Monitor; Observational epidemiology; Oncology; Outcome; Participant; Pathway interactions; Patients; Pharmaceutical Preparations; Phase; Pilot Projects; Population; Population Sciences; Positioning Attribute; Preparation; Provider; Publishing; Qualitative Methods; Quality of life; Randomized; Randomized, Controlled Trials; Recording of previous events; Recurrence; Recurrent Malignant Neoplasm; Reporting; Research; Resources; Risk Reduction; Scientist; Solid; Specimen; Structure; Survival Rate; Symptoms; Technology; Testing; Training; Treatment Efficacy; Trust; Vulnerable Populations; Woman; Work; adjuvant endocrine therapy; behavior test; behavioral clinical trial; black patient; black women; cancer care; cancer diagnosis; cancer health disparity; cancer recurrence; candidate identification; care delivery; career; career development; comparative efficacy; disparity reduction; efficacy evaluation; efficacy trial; experience; health care disparity; health disparity populations; hormone receptor-positive; hormone therapy; improved; innovation; intervention participants; intervention refinement; mHealth; mHealth methodology; malignant breast neoplasm; medication compliance; pilot test; programs; racial diversity; racism; randomized trial; randomized, clinical trials; recruit; skills; social cognitive theory; survival disparity; symposium; symptom management; tailored messaging; theories; therapy adherence; therapy development; treatment as usual; urinary

PROJECT SUMMARY Candidate Goals. My career goal is to reduce breast cancer health disparities in outcomes by addressing cancer care delivery issues in minority cancer populations. I received a solid foundation in observational epidemiological methods which I have applied to cancer survivorship research, but my training has not provided the skills I need to develop mHealth behavioral interventions or culturally-tailor and test behavioral interventions. The K08 provides an ideal opportunity to develop the necessary skills to achieve my long-term career goal as an independent clinical scientist. Candidate Career Development Plan. In this application, I propose training to develop the skills necessary to become a leader in the field of developing mHealth behavioral interventions for medication adherence and other cancer care delivery issues in minority cancer survivors. Training will be obtained through participation in scientific conferences, methods workshop, coursework, and structed mentorship from experts in developing culturally tailored behavioral interventions (Dr. Clement Gwede), adherence to endocrine therapy among patients with breast cancer (Dr. Dawn Hershman), mHealth methodology (Dr. Brian Gonzalez), randomized clinical trials of behavioral interventions (Dr. Heather Jim), recruitment and retention of minority participants to clinical studies (Dr. Susan Vadaparampil), and Biospecimen quality and testing (Dr. Shelley Tworoger). This training will ensure that I achieve my short-term goals after which I will be uniquely positioned to bridge gaps across disciplines, including: 1) Clinical breast cancer care, 2) Behavioral intervention development, cultural tailoring, and testing, and 3) Using mobile health technologies and biologic specimens in studies among vulnerable populations. Institutional Environment. The research environment, facilities, and resources at Moffitt Cancer Center are ideal for career development and I have the full support of my Department Chair, Dr. Czerniecki and Associate Center Director of the Division of Population Sciences, Dr. Shelley Tworoger. Research Plan. We propose an iterative approach to develop and pilot test a new mHealth behavioral intervention for AET adherence that is culturally tailored to Black breast cancer survivors. We will first use qualitative methods informed by Black breast cancer survivors to develop a blueprint of the intervention (Aim 1). We will then iteratively refine and culturally tailor the mHealth intervention focusing on symptom monitoring and management (Aim 2). Lastly, we will test the intervention for acceptability, feasibility, and preliminary efficacy (Aim 3). This project will address quality of life (symptom burden) and care delivery (medication adherence) issues in a health disparity population.

项目概要 候选人的目标。我的职业目标是通过解决以下问题来减少乳腺癌健康结果的差异 少数癌症人群的癌症护理提供问题。我在观察方面获得了坚实的基础 我已将流行病学方法应用于癌症生存研究，但我的培训并没有 提供了我开发移动医疗行为干预措施或文化定制和测试行为所需的技能 干预措施。 K08 提供了一个理想的机会来培养必要的技能，以实现我的长期目标 作为独立临床科学家的职业目标。 候选人职业发展计划。在此应用程序中，我建议进行培训以培养必要的技能 成为开发 mHealth 行为干预领域的领导者，以促进药物依从性和 少数癌症幸存者的其他癌症护理提供问题。培训将通过参加 科学会议、方法研讨会、课程作业以及开发方面专家的指导 根据文化量身定制的行为干预措施（Clement Gwede 博士）、坚持内分泌治疗 乳腺癌患者（Dawn Hershman 博士），移动医疗方法（Brian Gonzalez 博士），随机 行为干预的临床试验（希瑟吉姆博士），招募和保留少数族裔参与者 临床研究（Susan Vadaparampil 博士）和生物样本质量和测试（Shelley Tworoger 博士）。这 培训将确保我实现短期目标，之后我将处于独特的地位来弥合差距 跨学科，包括：1）临床乳腺癌护理，2）行为干预发展，文化 定制和测试，以及 3) 在研究中使用移动医疗技术和生物样本 弱势群体。 制度环境。莫菲特癌症中心的研究环境、设施和资源是 职业发展的理想选择，我得到了系主任 Czerniecki 博士和同事的全力支持 人口科学部中心主任 Shelley Tworoger 博士。 研究计划。我们提出了一种迭代方法来开发和试点测试新的移动医疗行为 针对黑人乳腺癌幸存者的文化量身定制的 AET 依从性干预措施。我们将首先使用 由黑人乳腺癌幸存者提供的定性方法来制定干预蓝图（目标 1）。然后，我们将迭代完善和文化定制移动医疗干预措施，重点关注症状监测 和管理（目标 2）。最后，我们将测试干预措施的可接受性、可行性和初步效果 功效（目标 3）。该项目将解决生活质量（症状负担）和护理服务（药物治疗） 依从性）健康差异人群中的问题。