Bioenergetic and Cardiometabolic Consequences of the Loss of Gonadal Function

性腺功能丧失的生物能和心脏代谢后果

基本信息

批准号：
10712608
负责人：
Wendy M Kohrt
金额：
$ 150万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-20 至 2028-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10712608
关键词：
Abdomen Acceleration Address Advisory Committees Aging Area Award Benchmarking Bioenergetics Biological Biometry Career Mobility Centers of Research Excellence Chronic Disease Clinical Clinical Sciences Colorado Communities Diabetes Mellitus Disease Education Educational Activities Educational Curriculum Elderly Estradiol Estrogens Evaluation Research Exercise Faculty Failure Family Fatty acid glycerol esters Female Functional disorder Goals Gonadal Steroid Hormones Grant Health Homeostasis Institution Interdisciplinary Study Knowledge Kynurenine Leadership Life Mediating Medical Menopause Mentors Metabolic Metabolism Modeling Obesity Osteoporosis Ovarian Pathway interactions Pilot Projects Positioning Attribute Postdoctoral Fellow Process Productivity Program Development Recording of previous events Regulation Reproductive Health Research Research Personnel Research Project Grants Resources Risk Scientist Sex Differences Specialized Center Testosterone Time Training Training Activity Training Programs Translational Research Tryptophan Universities Visit Wages Withdrawal Woman Women&apos s Health abdominal fat cardiometabolism career career development clinical translation data management expectation experience gonad function heart disease risk improved innovation interest investigator training male meetings men middle age multidisciplinary next generation novel nutrition pre-clinical prevent programs sex symposium synergism translational pipeline

项目摘要

The Colorado Specialized Center of Research Excellence (SCORE) on Sex Differences and Women’s Health is focused on Bioenergetic and Cardiometabolic Consequences of the Loss of Gonadal Function. The overarching scientific goal of the SCORE is to address gaps in knowledge of the impact of gonadal aging on the regulation of energy homeostasis and metabolism by conducting mechanistically driven research across the basic-to-clinical translational spectrum. The scientific premise is that gonadal aging, through the accompanying decline in sex hormones, mediates biological changes that increase risk for chronic disease. Importantly, because gonadal failure is inevitable in women in mid-life, but rare in men until much later in life, this meets the objective of the SCORE Program to study sex differences that impact women’s health. The Colorado SCORE is focused on the increased propensity for abdominal fat accumulation and the associated cardiometabolic dysfunction that are consequent to the loss of ovarian function. The overarching educational objective is to engage new investigators in research aligned with the focus of the SCORE. The SCORE will provide mentored career development and training on how to conduct research that appropriately addresses sex as a biological variable (SABV). These overarching objectives will be accomplished through the following Aims: 1) Advance novel translational research on mechanisms that are postulated to contribute to the abdominal adiposity and cardiometabolic dysfunction that accelerate following estradiol withdrawal. All projects include a focus on the kynurenine pathway because of the emerging evidence that it regulates energy homeostasis, metabolic function, and the aging process. The Colorado SCORE investigators are experts in these areas and are exceptionally well positioned to advance this research. 2) Attract and support outstanding early career investigators with research interests related to the SCORE and engage them in CEC training activities that will successfully advance their careers. The SCORE will support one Scholar and four Pilot Project Awardees each year. 3) Provide infrastructural support for the SCORE Research Projects, Scholars, and Pilot Awardees through the LAC, including biostatistics, data management, financial oversight, and administrative support. 4) Partner with and leverage resources provided by other programs at CU-AMC (Multidisciplinary Center on Aging, Ludeman Center for Women’s Health Research, Nutrition Obesity Research Center, Clinical and Translational Sciences Institute) to elevate the visibility and multi-disciplinary reach of women’s health research and the importance of investigating SABV. Activities will target both scientific and lay communities at local, regional, and national levels. Achieving these Aims will position the SCORE as a national leader in women’s health research, and the CEC as a model program for training the next generation of scientists to integrate SABV in their research with a goal of improving women’s health.

科罗拉多州专业的研究卓越中心（得分）关于性别差异和妇女健康专注于性腺功能丧失的生物能和心脏代谢后果。这该分数的总体科学目标是解决有关性腺衰老对影响的差距通过对跨机械驱动的研究进行机械驱动的研究来调节能量体内稳态和代谢基本转换的翻译光谱。科学的前提是性腺衰老，通过随着性激素的下降，介导生物学变化，增加了慢性疾病的风险。重要的是，由于中期女性不可避免地性伴腺衰竭，但在男性中很少见，直到生命的晚期，这符合分数计划的目标，以研究影响妇女健康的性别差异。这科罗拉多州的分数集中于腹部脂肪积累的可靠性和相关性心脏代谢功能障碍是卵巢功能丧失所致。总体教育目的是让新的研究人员参与与分数重点保持一致的研究。分数将提供了指导的职业发展和有关如何进行适当解决的研究的培训性作为生物变量（SABV）。这些总体对象将通过以下来完成目的：1）提前对据说有助于有助于的机制的新型翻译研究雌二醇退出后加速加速的腹部肥胖和心脏代谢功能障碍。所有项目由于新兴的证据表明它可以调节能量稳态，代谢功能和衰老过程。科罗拉多州得分调查员是专家这些领域，并且非常适合推进这项研究。 2）吸引和支持杰出具有与分数有关的研究兴趣的早期职业研究者，并参与CEC培训将成功发展职业的活动。该分数将支持一个学者和四个飞行员每年获奖者。 3）为分数研究项目提供基础设施支持，学者，和通过LAC的飞行员获奖者，包括生物统计学，数据管理，财务监督以及行政支持。 4）与CU-AMC其他计划提供的合作并利用并利用资源（Ludeman妇女健康研究中心，营养肥胖研究中心多学科中心中心，临床和转化科学研究所），以提高可见度和多学科范围妇女的健康研究以及调查SABV的重要性。活动将针对科学和局面地方，地区和国家一级的社区。实现这些目标将使分数定位为妇女健康研究的国家领导者和CEC作为培训下一个培训的模型计划一代科学家将SABV整合到他们的研究中，以改善妇女健康。