High Resolution Ultrasound in Interventional Radiology

介入放射学中的高分辨率超声

• 批准号: 10584507
• 负责人: Katherine W Ferrara
• 金额: $ 60.61万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-04 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10584507
• 关键词: Abdomen; Ablation; Acceleration; Acoustics; Address; Adult; Adverse effects; Algorithms; Anatomy; Animals; Biopsy; Blood flow; Buffers; California; Cancerous; Clinical; Color; Contrast Media; Cyst; Dedications; Dependence; Diagnosis; Diagnostic Imaging; Dimensions; Disease; Electronics; Elements; Exposure to; Family suidae; Future; Geometry; Hospitals; Image; Image Enhancement; Imaging Device; Individual; Intervention; Intervention Studies; Interventional Imaging; Interventional radiology; Ionizing radiation; Lesion; Liquid substance; Liver; Magnetic Resonance Imaging; Maps; Medical Device; Medical Imaging; Methods; Monitor; Needle biopsy procedure; Needles; Noise; Operative Surgical Procedures; Patients; Performance; Physiology; Procedures; Protocols documentation; Radiation; Radiation Dose Unit; Radiology Specialty; Resolution; Resource-limited setting; Scanning; Signal Transduction; Speed; System; Systems Integration; Technology; Testing; Time; Tissues; Transducers; Ultrasonography; Universities; Update; Vision; Visualization; X-Ray Computed Tomography; angiogenesis; clinical application; contrast enhanced; contrast enhanced computed tomography; contrast imaging; cost; design; high resolution imaging; image guided; image guided intervention; imaging capabilities; imaging modality; imaging software; imaging study; imaging system; improved; in vivo; liver ablation; liver imaging; liver visualization; microwave ablation; minimally invasive; nephrotoxicity; novel; technology development; technology platform; three-dimensional visualization; tool; transmission process; tumor; ultrasound; vector; volunteer; Abdomen; Ablation; Acceleration; Acoustics; Address; Adult; Adverse effects; Algorithms; Anatomy; Animals; Biopsy; Blood flow; Buffers; California; Cancerous; Clinical; Color; Contrast Media; Cyst; Dedications; Dependence; Diagnosis; Diagnostic Imaging; Dimensions; Disease; Electronics; Elements; Exposure to; Family suidae; Future; Geometry; Hospitals; Image; Image Enhancement; Imaging Device; Individual; Intervention; Intervention Studies; Interventional Imaging; Interventional radiology; Ionizing radiation; Lesion; Liquid substance; Liver; Magnetic Resonance Imaging; Maps; Medical Device; Medical Imaging; Methods; Monitor; Needle biopsy procedure; Needles; Noise; Operative Surgical Procedures; Patients; Performance; Physiology; Procedures; Protocols documentation; Radiation; Radiation Dose Unit; Radiology Specialty; Resolution; Resource-limited setting; Scanning; Signal Transduction; Speed; System; Systems Integration; Technology; Testing; Time; Tissues; Transducers; Ultrasonography; Universities; Update; Vision; Visualization; X-Ray Computed Tomography; angiogenesis; clinical application; contrast enhanced; contrast enhanced computed tomography; contrast imaging; cost; design; high resolution imaging; image guided; image guided intervention; imaging capabilities; imaging modality; imaging software; imaging study; imaging system; improved; in vivo; liver ablation; liver imaging; liver visualization; microwave ablation; minimally invasive; nephrotoxicity; novel; technology development; technology platform; three-dimensional visualization; tool; transmission process; tumor; ultrasound; vector; volunteer

We seek to create a real-time ultrasound imaging tool for guiding interventions, with resolution that exceeds that obtained using CT but without the need for radiation or iodinated contrast agents. Advancements in medical imaging and device technology allow minimally-invasive procedures for the diagnosis and treatment of various disorders. Real-time ultrasound has become an integral aspect of many image-guided interventions. Advantages of US imaging include the low cost, lack of ionizing radiation and real-time visualization of anatomy and physiology. Our approach will be to: 1) create an extended aperture 2D transducer (512 by 16 elements) capable of imaging an extended azimuthal field of 9 cm with in-plane resolution of hundreds of microns (to provide a wide field of view at high resolution), 2) apply the 2D array to image multiple adjacent planes (to facilitate the view of biopsy needles or ablations), 3) achieve a 30 volume per second update rate by using plane wave transmissions to enhance contrast imaging modes and implement novel beam formation algorithms, 4) integrate methods for aberration correction, and 5) apply this technology in B-Mode, color Doppler, volumetric vector flow imaging and contrast imaging. The array will be realized using tiled modules that can be switched in a mode-dependent fashion to accomplish B-Mode imaging, color Doppler and contrast imaging. Over the past 4 years, Stanford and the University of Southern California have designed an adult extended-aperture abdominal-imaging system and demonstrated the improved spatial resolution, field of view and contrast that can be achieved. We exploit these tools here to develop a high-volume rate capability for monitoring liver interventions. Our aims to accomplish this are to: 1) Create and integrate tileable acoustic/electronic modules to implement signal buffering and multiplexing and create a large aperture array with elevational focusing. Utilizing newly designed Integrated Circuits (IC)’s and highly sensitive and wide-bandwidth single crystal transducer material, we will construct individual 2D array modules with co-integrated transducers and electronics. 2) Optimize the protocols for guiding biopsy and ablation in phantom and animal studies. A) Create software for imaging of small lesions and microwave ablation. We will implement singular value decomposition (SVD) based beam formation for aberration correction. B) Evaluate performance in phantoms and ex vivo tissue. C) Assess speed and accuracy of needle placements. D) Conduct contrast imaging and ablative studies in porcine liver in vivo. 3) Conduct diagnostic and interventional imaging studies as a proof of concept. A) Test the protocols to image the liver of adult volunteers and establish the signal to noise ratio in vivo as compared with phantoms. B) Assess 3D visualization of liver vasculature and lesions in patients referred for MR or CT imaging of a liver lesion. C) Compare the 3D visualization of ablated zones to contrast-enhanced CT (CECT) in patients that are referred for liver ablation.

我们试图创建一个实时超声成像工具，用于指导干预措施，解决方案超出了该工具 使用CT获得，但不需要辐射或碘化对比剂。医疗的进步 成像和设备技术允许最低侵入性的程序来诊断和处理各种 疾病。实时超声已经成为许多图像引导干预措施的组成部分。优势 美国成像包括低成本，缺乏电离辐射以及解剖结构的实时可视化和 生理。我们的方法将是：1）创建一个能够 成像一个9厘米的延长方位角，平面分辨率为数百微米（以提供较宽的 高分辨率的视野），2）将2D阵列应用于图像多个相邻平面（以促进视图 活检针或消融），3）使用平面波传输实现每秒30卷的更新速率 为了增强对比成像模式并实现新型梁的形成算法，4） 畸变校正和5）将此技术应用于B模式，颜色多普勒，体积矢量流成像和 对比成像。阵列将使用可以在模式下切换的瓷砖模块来实现 完成B模式成像，颜色多普勒和对比成像的时尚。在过去的四年中，斯坦福和 南加州大学设计了一个成人扩展的腹部成像系统， 证明了可以实现的空间分辨率，视野和对比度的改进。我们利用这些 这里的工具可以开发高体积速率能力来监测肝脏干预措施。我们的目标是实现这一目标 为：1）创建和集成可瓦的声学/电子模块以实现信号缓冲和多路复用 并创建一个具有高度聚焦的大孔径阵列。利用新设计的集成电路（IC） 以及高度敏感和宽带的单晶传感器材料，我们将构建单个2D阵列 具有协调的换能器和电子设备的模块。 2）优化指导活检和消融的方案 在幻影和动物研究中。 a）创建用于成像小病变和微波消融的软件。我们 将实施基于单数值分解（SVD）的梁形成，以进行像差校正。 b）评估 幻象和离体组织的性能。 c）评估针头放置的速度和准确性。 d）行为 在体内猪肝脏中的对比成像和烧烤研究。 3）进行诊断和介入成像 研究作为概念证明。 a）测试图像成年志愿者肝脏的方案并建立信号 与幻像相比，体内噪声比。 b）评估肝脉管系统和病变的3D可视化 患者转介肝病变的MR或CT成像。 c）比较消融区的3D可视化与 在转介肝脏消融的患者中，对比增强的CT（CECT）。