Molecular Transducers of Physical Activity Consortium - Colorado Clinical Center

身体活动联盟分子传感器 - 科罗拉多临床中心

基本信息

批准号：
10265087
负责人：
Wendy M Kohrt
金额：
$ 3.59万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-12-06 至 2022-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10265087
关键词：
Acute Address Adult Advisory Committees Age American Animals Bioinformatics Biological Markers Biomedical Research Biopsy Blood specimen Chemicals Chronic Chronic Disease Clinical Clinical Investigator Clinical Research Clinical Trials Collection Colorado Common Data Element Complex Control Groups Cytomegalovirus Infections Data Analyses Disease Doctor of Philosophy Eligibility Determination Enrollment Ensure Exercise Faculty Foundations Future Goals Guidelines Health Health Benefit Hospitals Human Individual Information Dissemination Institution Institutional Review Boards Intervention Intervention Trial Investigation Knowledge Lead Longevity Manuals Manuscripts Maps Medical Medicine Metabolic Molecular Monitor Participant Phase Phenotype Physical activity Physiological Physiology Population Preparation Prevention Preventive Intervention Primary Prevention Procedures Protocols documentation Publications Reporting Research Research Activity Research Personnel Research Support Resistance Resources Review Committee Safety Sample Size Sampling Science Services Signal Pathway Signal Transduction Site System Testing Therapeutic Intervention TimeLine Tissue Sample Tissues Training Transducers Translational Research Universities animal data clinical center cohort data management data quality data sharing exercise intervention experience fitness human data improved interest meetings metabolic phenotype operation quality assurance recruit response screening success symposium

项目摘要

Physical activity (PA) has numerous and profound benefits on health and function, yet there is limited knowledge of the mechanistic signals that underlie these benefits. Such knowledge is critical for optimizing the effective use of PA as a preventive or therapeutic intervention strategy for specific diseases and in specific populations. The overarching goal of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) is to address this knowledge gap by characterizing the molecular responses to PA. This will be accomplished through the collection of blood and tissue samples from both humans and animals, which will then be subjected to extensive “Omics” analyses. By generating a comprehensive map of molecular responses to PA, MoTrPAC will lay the foundation for a new era of biomedical research on Precision Exercise Medicine. The University of Colorado Anschutz Medical Campus (CU-AMC) is exceptionally well poised to lead a MoTrPAC Adult Clinical Center and to contribute to all Consortium activities. Our investigators and collaborators have extensive experience with complex clinical PA intervention trials, including tissue sampling, in cohorts spanning the entire adult age spectrum. Our expertise extends across multiple physiological systems, diseases, and health conditions, and includes broad proficiency in physiologic, metabolic, and morphometric phenotyping. The facilities at CU-AMC for MoTrPAC activities are outstanding. The proposed MoTrPAC – Colorado Clinical Center will accomplish the following Specific Aims (SA): SA1: Contribute to, and lead when appropriate, all MoTrPAC Phase 1 planning activities (Year 1) described in RFA-RM-15-015 through participation on the MoTrPAC Steering Committee and Subcomittees. The local goals for Phase 1 will be to accomplish tasks (e.g., obtain regulatory approvals, train staff) that will enable Phase 2 to start at the beginning of Year 2. SA2: Recruit and enroll 450 adults at CU-AMC (or the number determined during Phase 1), conduct the acute PA tests and PA intervention according to protocols established by the Consortium, and carry out all other MoTrPAC Phase 2 activities (Years 2 to 5). Highly accomplished clinical investigators will lead the seven “teams” that will be responsible for: recruitment, screening, and retention; physiologic, metabolic, and morphometric phenotyping; biospecimen acquisition; biospecimen processing; acute PA tests; chronic PA interventions; and data management and quality assurance. SA3: As animal and human data become available from the Chemical Analysis Sites and Bioinformatics Center, we will participate in all Phase 3 activities, including data analysis, preparation of manuscripts, and dissemination of results. These activities will be guided by the MoTrPAC Steering Committee and Subcommittees. On the local level, we will host an annual 1-day local symposium on PA, Health, and Fitness to catalyze the interest of investigators at CU-AMC and other nearby academic institutions in MoTrPAC.

体力活动 (PA) 对健康和功能有许多深远的好处，但其效果有限了解这些好处背后的机械信号对于优化系统至关重要。有效利用 PA 作为特定疾病和特定疾病的预防或治疗干预策略身体活动分子传感器联盟 (MoTrPAC) 的总体目标是通过表征对 PA 的分子反应来解决这一知识空白。通过收集人类和动物的血液和组织样本，然后将其通过生成全面的分子反应图进行广泛的“组学”分析。 PA、MoTrPAC 将为精确运动生物医学研究的新时代奠定基础医学科罗拉多大学安舒茨医学校区 (CU-AMC) 已做好充分准备。领导 MoTrPAC 成人临床中心并为我们的研究人员和联盟的所有活动做出贡献。合作者在复杂的临床 PA 干预试验方面拥有丰富的经验，包括组织采样、我们的专业知识涵盖多个生理领域。系统、疾病和健康状况，包括生理、代谢和健康方面的广泛熟练程度 CU-AMC 用于 MoTrPAC 活动的设施非常出色。 MoTrPAC – 科罗拉多临床中心将实现以下具体目标 (SA)： SA1：在适当的时候促进并领导所有 MoTrPAC 第 1 阶段规划活动（第 1 年）。 RFA-RM-15-015 通过参与 MoTrPAC 指导委员会和小组委员会当地目标。第一阶段将完成任务（例如，获得监管批准、培训员工），使第二阶段能够从第二年年初开始。 SA2：在 CU-AMC 招募并注册 450 名成年人（或第一阶段确定的人数），进行急性根据联盟制定的协议进行 PA 测试和 PA 干预，并执行所有其他操作 MoTrPAC 第 2 期活动（第 2 至第 5 年）将由出色的临床研究人员领导。 “团队”将负责：招募、筛选和保留；形态测定表型分析；生物样本处理；慢性 PA 测试；干预措施；以及数据管理和质量保证。 SA3：随着动物和人类数据可从化学分析站点和生物信息学获得中心，我们将参与第三阶段的所有活动，包括数据分析、稿件准备，以及这些活动将由 MoTrPAC 指导委员会和在地方层面，我们将每年举办一次为期 1 天的关于 PA、健康和健身的地方研讨会。激发 CU-AMC 和 MoTrPAC 附近其他学术机构研究人员的兴趣。