Molecular Transducers of Physical Activity Consortium - Colorado Clinical Center

身体活动联盟分子传感器 - 科罗拉多临床中心

基本信息

批准号：
10840187
负责人：
Wendy M Kohrt
金额：
$ 200万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-12-06 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10840187
关键词：
17 year old 18 year old Acceleration Acute Adipose tissue Adult Age Ancillary Study Animals Attention Award Bioinformatics Biological Process Blood COVID-19 COVID-19 pandemic California Categories Charge Chemicals Child Childhood Chronic Clinical Clinical Protocols Clinical Research Clinical Trials Data Monitoring Committees Collaborations Collection Colorado Communication Communities Data Development Disease Disease Outcome Enrollment Ensure Ethnic Origin Exercise Frequencies Funding Gender Goals Health Health Benefit Heterogeneity Human Individual Institutional Review Boards Intervention Manuals Manuscripts Maps Measurement Minority Groups Molecular Multi-site clinical study Muscle Observational Study Participant Pathway interactions Pediatric cohort Phase Phenotype Physical activity Physiological Procedures Protocols documentation Public Health Race Randomized Randomized, Controlled Trials Recruitment Activity Research Research Personnel Resources Rest Site Suspensions Testing Time Tissues Training Transducers United States National Institutes of Health Universities Visit Woman Youth age group aged clinical center cohort comparison group endurance exercise ethnic minority exercise intervention exercise training falls follow-up improved innovation insight men multiple omics novel operation pandemic disease phenotypic data pre-clinical public database quality assurance racial minority recruit resistance exercise response sedentary sex working group

项目摘要

MoTrPAC Project Summary The Molecular Transducers of Physical Activity Consortium (MoTrPAC) will discover and characterize the range of potential molecular transducers that underlie the health benefits of exercise in humans. MoTrPAC was launched in 2016 with six adult Clinical Centers and a pediatric Clinical Center that have collaborated to generate extensive Manuals of Operations to guide research protocols involving all aspects of clinical operations (Phase I). Phase II began in the fall of 2019 with all Clinical Centers demonstrating excellent progress toward initial recruitment goals and implementation of the protocol. The initial goal set forth by the Consortium was to recruit 270 children (10-17 years of age) and 1,980 sedentary adults (aged 18+ years of age) who are randomized to endurance exercise training (170 youth, 840 adults), resistance exercise training (840 adults), or no-exercise control (50 youth, 300 adults) interventions. Additional groups of highly active endurance trained (50 youth, 150 adults) or resistance trained (150 adults) individuals serve as comparator groups and do not undergo the MoTrPAC exercise interventions. The recruitment and enrollment approaches are sex balanced, with participants across a wide age range (10-17, 18-39, 40-59, and 60+ age groups) and of different races and ethnicity. Due to the COVID-19 pandemic, some MoTrPAC activities were suspended for more than a year, beginning in March 2020, with continued constraints through 2022. Despite the numerous challenges encountered as a result of the pandemic, recruitment activities at the adult and pediatric Clinical Centers have accelerated to a rate that is projected to successfully achieve the target enrollment numbers by the end of the new award period. This led the NIH Common Fund to release the current NOFO (RFA-RM-23-010) to provide MoTrPAC with funding to complete recruitment and follow-up for the clinical studies, including finishing mechanistic randomized controlled trials of sedentary adults and children and observational studies of highly active adults and children. This will enrich the participant cohorts that are critical to understand the heterogeneity of exercise adaptations across age, gender, and minority groups. This extension will enable MoTrPAC to complete the intended goals as originally envisioned and will provide a more complete public database of the health benefits of exercise and provide insight into how physical activity mitigates disease.

MoTrPAC 项目概要体力活动分子传感器联盟 (MoTrPAC) 将发现并表征一系列潜在的分子传感器是运动对人类健康有益的基础。莫特尔PAC 于 2016 年推出，与六个成人临床中心和一个儿科临床中心合作生成广泛的操作手册来指导涉及临床各个方面的研究方案运营（第一阶段）。第二阶段于 2019 年秋季开始，所有临床中心均表现出色初步招募目标和议定书实施方面的进展。最初提出的目标是该联盟计划招募 270 名儿童（10-17 岁）和 1,980 名久坐的成年人（18 岁以上）岁），随机接受耐力运动训练（170 名青少年，840 名成人）、阻力运动训练（840 名成人）或无运动控制（50 名青少年，300 名成人）干预措施。附加组接受过高度活跃耐力训练的人（50 名青少年，150 名成人）或接受过阻力训练的人（150 名成人）作为比较组，不接受 MoTrPAC 运动干预。招聘招生方式性别平衡，参与者年龄范围广泛（10-17、18-39、 40-59 岁和 60 岁以上年龄组）以及不同种族和民族。由于 COVID-19 大流行，一些自 2020 年 3 月开始，MoTrPAC 活动暂停了一年多，到 2022 年，尽管疫情带来了诸多挑战，成人和儿科临床中心的招募活动已加速到预计的速度在新的奖励期结束时成功实现目标入学人数。这导致了 NIH 共同基金将发布当前的 NOFO (RFA-RM-23-010)，为 MoTrPAC 提供资金完成临床研究的招募和随访，包括完成机械随机化对久坐的成人和儿童进行的对照试验以及对高度活跃的成人和儿童进行的观察性研究孩子们。这将丰富对于理解运动异质性至关重要的参与者群体跨年龄、性别和少数群体的适应性。此扩展将使 MoTrPAC 能够完成预期目标与最初设想一致，并将提供更完整的公共健康数据库锻炼的好处，并深入了解身体活动如何减轻疾病。