Molecular Transducers of Physical Activity Consortium - Colorado Clinical Center

身体活动联盟分子传感器 - 科罗拉多临床中心

基本信息

批准号：
10320753
负责人：
Wendy M Kohrt
金额：
$ 251.75万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-12-06 至 2023-09-22
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10320753
关键词：
Acute Address Adult Advisory Committees Age American Animals Bioinformatics Biological Markers Biomedical Research Biopsy Blood specimen Chemicals Chronic Chronic Disease Clinical Clinical Investigator Clinical Research Clinical Trials Collection Colorado Common Data Element Complex Control Groups Cytomegalovirus Infections Data Analyses Disease Doctor of Philosophy Eligibility Determination Enrollment Ensure Exercise Faculty Foundations Future Goals Guidelines Health Health Benefit Hospitals Human Individual Information Dissemination Institution Institutional Review Boards Intervention Intervention Trial Investigation Knowledge Lead Longevity Manuals Manuscripts Maps Medical Medicine Metabolic Molecular Monitor Participant Phase Phenotype Physical activity Physiological Physiology Population Preparation Prevention Primary Prevention Procedures Protocols documentation Publications Reporting Research Research Activity Research Personnel Research Support Resistance Resources Review Committee Safety Sample Size Sampling Science Services Signal Pathway Signal Transduction Site System Testing Therapeutic Intervention TimeLine Tissue Sample Tissues Training Transducers Translational Research Universities animal data clinical center cohort data management data quality data sharing exercise intervention experience fitness human data improved interest meetings metabolic phenotype operation preventive intervention quality assurance recruit response screening success symposium

Acute Address Adult Advisory Committees Age American Animals Bioinformatics Biological Markers Biomedical Research Biopsy Blood specimen Chemicals Chronic Chronic Disease Clinical Clinical Investigator Clinical Research Clinical Trials Collection Colorado Common Data Element Complex Control Groups Cytomegalovirus Infections Data Analyses Disease Doctor of Philosophy Eligibility Determination Enrollment Ensure Exercise Faculty Foundations Future Goals Guidelines Health Health Benefit Hospitals Human Individual Information Dissemination Institution Institutional Review Boards Intervention Intervention Trial Investigation Knowledge Lead Longevity Manuals Manuscripts Maps Medical Medicine Metabolic Molecular Monitor Participant Phase Phenotype Physical activity Physiological Physiology Population Preparation Prevention Primary Prevention Procedures Protocols documentation Publications Reporting Research Research Activity Research Personnel Research Support Resistance Resources Review Committee Safety Sample Size Sampling Science Services Signal Pathway Signal Transduction Site System Testing Therapeutic Intervention TimeLine Tissue Sample Tissues Training Transducers Translational Research Universities animal data clinical center cohort data management data quality data sharing exercise intervention experience fitness human data improved interest meetings metabolic phenotype operation preventive intervention quality assurance recruit response screening success symposium

展开

项目摘要

Physical activity (PA) has numerous and profound benefits on health and function, yet there is limited knowledge of the mechanistic signals that underlie these benefits. Such knowledge is critical for optimizing the effective use of PA as a preventive or therapeutic intervention strategy for specific diseases and in specific populations. The overarching goal of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) is to address this knowledge gap by characterizing the molecular responses to PA. This will be accomplished through the collection of blood and tissue samples from both humans and animals, which will then be subjected to extensive “Omics” analyses. By generating a comprehensive map of molecular responses to PA, MoTrPAC will lay the foundation for a new era of biomedical research on Precision Exercise Medicine. The University of Colorado Anschutz Medical Campus (CU-AMC) is exceptionally well poised to lead a MoTrPAC Adult Clinical Center and to contribute to all Consortium activities. Our investigators and collaborators have extensive experience with complex clinical PA intervention trials, including tissue sampling, in cohorts spanning the entire adult age spectrum. Our expertise extends across multiple physiological systems, diseases, and health conditions, and includes broad proficiency in physiologic, metabolic, and morphometric phenotyping. The facilities at CU-AMC for MoTrPAC activities are outstanding. The proposed MoTrPAC – Colorado Clinical Center will accomplish the following Specific Aims (SA): SA1: Contribute to, and lead when appropriate, all MoTrPAC Phase 1 planning activities (Year 1) described in RFA-RM-15-015 through participation on the MoTrPAC Steering Committee and Subcomittees. The local goals for Phase 1 will be to accomplish tasks (e.g., obtain regulatory approvals, train staff) that will enable Phase 2 to start at the beginning of Year 2. SA2: Recruit and enroll 450 adults at CU-AMC (or the number determined during Phase 1), conduct the acute PA tests and PA intervention according to protocols established by the Consortium, and carry out all other MoTrPAC Phase 2 activities (Years 2 to 5). Highly accomplished clinical investigators will lead the seven “teams” that will be responsible for: recruitment, screening, and retention; physiologic, metabolic, and morphometric phenotyping; biospecimen acquisition; biospecimen processing; acute PA tests; chronic PA interventions; and data management and quality assurance. SA3: As animal and human data become available from the Chemical Analysis Sites and Bioinformatics Center, we will participate in all Phase 3 activities, including data analysis, preparation of manuscripts, and dissemination of results. These activities will be guided by the MoTrPAC Steering Committee and Subcommittees. On the local level, we will host an annual 1-day local symposium on PA, Health, and Fitness to catalyze the interest of investigators at CU-AMC and other nearby academic institutions in MoTrPAC.

体育锻炼（PA）对健康和功能有许多且深厚的好处，但是有限了解基于这些好处的机械信号。这种知识对于优化有效使用PA作为特定疾病的预防或治疗干预策略，人群。体育活动联盟（MOTRPAC）的分子传感器的总体目标是通过表征对PA的分子响应来解决这一知识差距。这将完成通过收集来自人类和动物的血液和组织样本，然后是进行广泛的“ OMICS”分析。通过生成对分子响应的综合图 PA，MOTRPAC将为精确锻炼的生物医学研究的新时代奠定基础药品。科罗拉多大学安索特大学医学校园（CU-AMC）非常有毒领导Motrpac成人临床中心，并为所有财团活动做出贡献。我们的调查人员和合作者在复杂的临床PA干预试验中拥有丰富的经验，包括组织采样，在整个成人年龄段的同类中。我们的专家跨越多种生理系统，疾病和健康状况，包括广泛的生理，代谢和形态计量表型。 CU-AMC的MOTRPAC活动的设施非常出色。提议 MOTRPAC - 科罗拉多州临床中心将完成以下特定目标（SA）： SA1：在适当的情况下为所有Motrpac 1阶段计划活动（1年级）做出贡献（1年） RFA-RM-15-015通过参加MOTRPAC指导委员会和小组委员会。本地目标对于第1阶从第二年初开始。 SA2：在Cu-AMC（或第1阶段确定的数量）的招募和招募450名成年人，进行急性 PA测试和PA干预根据财团建立的协议，并执行所有其他 MOTRPAC 2期活动（2至5年）。高度成就的临床研究人员将领导七个将负责的“团队”：招聘，筛查和保留；生理，代谢和形态计量表型；生物循环收购；生物循环处理；急性PA测试；慢性PA 干预措施；以及数据管理和质量保证。 SA3：随着动物和人类数据从化学分析站点和生物信息学获得中心，我们将参加所有3阶段活动，包括数据分析，手稿的准备和结果传播。这些活动将由Motrpac指导委员会和小组委员会。在地方一级，我们将在PA，Health和Fitness上举办一年一度的为期1天的本地研讨会催化Cu-AMC和Motrpac附近其他学术机构的研究人员的兴趣。