Bioenergetic and Metabolic Consequences of the Loss of Gonadal Function

性腺功能丧失的生物能和代谢后果

基本信息

批准号：
10456782
负责人：
Wendy M Kohrt
金额：
$ 149万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-20 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10456782
关键词：
Abdomen Address Adipocytes Aging Area Award Benchmarking Bioenergetics Biological Biometry Bone Density Bone Marrow Career Mobility Centers of Research Excellence Chronic Disease Clinical Clinical Sciences Colorado Communities Diabetes Mellitus Disease Educational Curriculum Elderly Ensure Environment Estradiol Estrogens Evaluation Evaluation Research Faculty Failure Fatty acid glycerol esters Female Follicle Stimulating Hormone Glucocorticoids Goals Gonadal Steroid Hormones Grant Inflammatory Infrastructure Institutes Interdisciplinary Study Knowledge Leadership Life Mediating Medical Menopause Mentors Metabolic Metabolic dysfunction Metabolism Modeling Mus Obesity Osteoporosis Outcome Pilot Projects Positioning Attribute Postdoctoral Fellow Process Productivity Program Development Recording of previous events Regulation Reproductive Health Research Research Personnel Research Project Grants Research Support Resources Risk Seeds Sex Differences Specialist Specialized Center Testosterone Time Training Training Activity Training Programs Translational Research Universities Visit Wages Woman Women&apos s Health abdominal fat career career development data management disorder risk expectation genetic signature gonad function heart disease risk improved innovation interest male meetings men middle age multidisciplinary novel nutrition pre-clinical prevent progenitor programs sex symposium translational pipeline

项目摘要

The Colorado Specialized Center of Research Excellence on Sex Differences (CO-SCORE) is thematically focused on Bioenergetic and Metabolic Consequences of the Loss of Gonadal Function. The overarching scientific objective of the CO-SCORE is to advance knowledge of the impact of gonadal aging on the regulation of bioenergetics, abdominal adiposity, and metabolism by conducting mechanistically-driven research across the basic-to-clinical translational spectrum. The scientific premise is that gonadal failure mediates biological changes that increase risk for chronic disease. The most well-studied example of this is the accelerated decline in bone mineral density at menopause and the associated osteoporosis risk. However, the extent to which gonadal failure increases risk for chronic diseases other than osteoporosis is poorly understood. This is a particularly important knowledge gap in women’s health, because gonadal failure is inevitable in women in mid-life, but rare in men until much later in life. The overarching educational objective is to engage new investigators in research aligned with the thematic focus of the CO-SCORE. The CO-SCORE will promote mentored career development and provide training on how to conduct research that appropriately addresses sex as a biological variable (SABV). These central objectives will be accomplished through the following Aims: 1) The three CO-SCORE Research Projects (basic, preclinical, and clinical) will advance cutting-edge, paradigm-challenging translational research on novel mechanisms postulated to contribute to the increased abdominal adiposity and associated metabolic dysfunction that occur in the estrogen-deficient state;; 2) The Career Enhancement Core (CEC) will provide a rich training environment to attract and support outstanding junior investigators with research interests related to the thematic focus of the CO-SCORE. SCORE Scholars and Pilot Awardees will be selected through a competitive process and participate in a comprehensive career development program;; 3) The Leadership Administrative Core (LAC) will provide infrastructural support for the Research Projects, CO-SCORE Pilot Projects, and the CEC, including biostatistics, data management, financial oversight, and administrative support. An evaluation specialist will use innovative strategies for assessing whether the research, trainees, mentors, and the CO-SCORE as a whole are achieving a high level of impact and reach;; and 4) The CO-SCORE will partner with other Centers and Programs at CU-AMC to elevate the visibility and multi-disciplinary reach of women’s health research and the importance of investigating SABV. Activities will target both scientific and lay communities at local, regional, and national levels. Achieving these Aims will position the CO-SCORE as a national leader in our targeted areas of women’s health research, and the CEC as a model program for training junior investigators to appropriately integrate SABV into their research, thereby addressing the ultimate goal of the SCORE program of improving the health of women.

科罗拉多州专业的性别差异研究中心（共同得分）是主题的专注于性腺功能丧失的生物能和代谢后果。总体共同评分的科学目标是提高对性腺衰老对衰老的影响的了解通过机械驱动的调节生物能学，腹部肥胖和代谢的调节跨基本翻译光谱进行研究。科学前提是性腺衰竭介导生物学变化，增加慢性疾病的风险。最深思的例子是更年期和相关骨质疏松症的风险加速了骨矿物质密度的下降。但是，性腺衰竭增加骨质疏松症以外的慢性疾病风险的程度很差理解齿。这是女性健康中特别重要的知识差距，因为性腺衰竭是在中年的女性中不可避免，但在男性中很少见，直到生命的晚期。总体教育目标是让新的研究人员参与与共同得分的主题重点保持一致的研究。共同得分将促进受过指导的职业发展，并提供有关如何进行适当研究的培训将性作为生物变量（SABV）。这些中心目标将通过以下目的：1）三个共同得分研究项目（基本，临床前和临床）将进步关于新机制的尖端，范式挑战的转化研究，该研究被认为有助于在雌激素缺陷型状态下增加腹部肥胖和相关的代谢功能障碍； 2）职业增强核心（CEC）将为吸引和支持提供丰富的培训环境具有研究兴趣的杰出初级研究人员与共同得分的主题重点有关。得分学者和飞行员获奖者将通过竞争过程选择，并参与全面的职业发展计划; 3）领导行政核心（LAC）将提供研究项目，共同得分试点项目和CEC的基础设施支持，包括生物统计学，数据管理，财务监督和行政支持。评估专家将使用创新策略来评估研究，学员，导师和共同分数是否为整体正在实现高水平的影响和覆盖范围； 4）联合评分将与其他中心合作以及Cu-AMC的计划，以提高妇女健康研究的知名度和多学科范围调查SABV的重要性。活动将针对地方，地区的科学和外行社区，和国家一级。实现这些目标将使联合评分定位为我们的目标妇女健康研究领域和CEC作为培训初级调查人员的模型计划适当地集成了SABV，从而解决了分数计划的最终目标改善妇女的健康。