High-Definition Conformal Electronics for VT/VF

适用于 VT/VF 的高清保形电子器件

• 批准号: 10661291
• 负责人: IGOR R EFIMOV
• 金额: $ 62.33万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-10 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10661291
• 关键词: Address; Adopted; Algorithms; Arrhythmia; Canis familiaris; Cardiovascular system; Cessation of life; Development; Device Designs; Devices; Diagnostic; Dissociation; Economics; Electric Countershock; Electric Stimulation Therapy; Electronics; Filament; Frequencies; Future; Generations; Goals; Healthcare; Healthcare Systems; Heart; Hospitals; Human; Implantable Defibrillators; Individual; Knowledge; Laboratories; Lead; Location; Measures; Methods; Modeling; Myocardial Infarction; Optics; Organ; Oryctolagus cuniculus; Pain; Patients; Phase; Prevention; Quality of life; Research Personnel; Resolution; Shock; Tachycardia; Technology; Testing; Therapeutic; Time; Transillumination; Treatment Efficacy; United States; Ventricular; Ventricular Arrhythmia; Ventricular Fibrillation; Ventricular Tachycardia; Work; base; care burden; comorbidity; effective therapy; experimental study; implantable device; improved; in vivo; individual patient; individualized medicine; innovation; insight; myocardial damage; novel; novel strategies; prediction algorithm; psychological distress; public health relevance; sensor; side effect; sudden cardiac death

Project Summary/Abstract Ventricular arrhythmias including ventricular tachycardia (VT) and ventricular fibrillation (VF) are responsible for 300,000 sudden cardiac deaths a year in the US. Electrotherapy has been effective in arresting VT/VF but the high-energy biphasic shocks can lead to myocardial damage and associated co-morbidities. Moreover the implantable cardioverter defibrillator technology (ICD) has low VT/VF sensing resolution, which can lead to inappropriate shocks and associated psychological distress, resulting in diminished quality of life or even death. Thus, there is an unmet need for high-definition VT/VF sensing to reduce inappropriate shocks and similarly, an unmet need for high-definition ultra-low energy electrotherapy to terminate VT/VF. In this project, we present a novel approach to VT/VF sensing and electrotherapy and redesign the ICD into cardiovascular implantable electronic device (CIED). We will employ two break-through technological platforms to implement our novel method: (1) A novel conformal chiplet electronics real-time networks (CCERN) technology developed by Co-Investigator Dr. Rogers and an (2) innovative panoramic, transillumination optical mapping developed by PI Dr. Efimov. We will conduct high-definition, panoramic, transillumination, optical mapping in conjunction with high-definition CCERN to (1) characterize the transmural VT/VF dynamics, (2) determine the optimal number of sensors needed to dynamically track the excitable gaps, phase singularities, and wavefronts during VT/VF, and (3) terminate VT/VF using optimal definition ultra low-energy high-definition electrotherapy. This proposed work would advance our understanding of VT/VF and pave the path towards creating a targeted individualized therapy dynamically tailored for each arrhythmia episode for each patient.

项目摘要/摘要 心室心律不齐，包括心室心动过速（VT）和心室纤维化（VF）是负责的 在美国，每年有300,000次心脏死亡。电疗法已有效逮捕VT/VF，但 高能双相冲击会导致心肌损伤和相关的合并症。而且 可植入的心脏逆变器除颤器技术（ICD）具有低VT/VF传感分辨率，可以导致 不适当的冲击和相关的心理困扰，导致生活质量降低甚至 死亡。因此，需要高清VT/VF感应以减少不适当的冲击和 同样，未满足的高清超低能量电位疗法需要终止VT/VF。在这个 项目，我们提出了一种新颖的VT/VF感应和电疗疗法的方法，然后将ICD重新设计为 心血管植入电子设备（CIED）。我们将采用两种突破性技术 实施我们的新方法的平台：（1）一种新型的共形芯片电子实时网络 （CCERN）由Rogers博士和（2）创新全景开发的技术， PI博士Efimov开发的透明光学图。我们将进行高清，全景， 透射，与高清CCERN结合使用的光学映射到（1）表征 透壁VT/VF动力学，（2）确定动态跟踪所需的最佳传感器数 VT/VF期间的可激发差距，相位奇点和波前，以及（3）使用最佳的VT/VF终止VT/VF 定义超低能高清电疗。这项建议的工作将推动我们的 了解VT/VF，并为创建目标个性化治疗的道路铺平道路 为每个患者量身定制每个心律失常发作。

项目成果

Optical Mapping.

• DOI: 10.1016/j.ccep.2019.04.004
• 发表时间: 2019-09-01
• 期刊: Cardiac electrophysiology clinics
• 作者: Berenfeld, Omer;Efimov, Igor
• 通讯作者: Efimov, Igor

Catheter-integrated soft multilayer electronic arrays for multiplexed sensing and actuation during cardiac surgery.

• DOI: 10.1038/s41551-020-00604-w
• 发表时间: 2020-10
• 期刊: Nature biomedical engineering
• 影响因子: 28.1
• 作者: Han M;Chen L;Aras K;Liang C;Chen X;Zhao H;Li K;Faye NR;Sun B;Kim JH;Bai W;Yang Q;Ma Y;Lu W;Song E;Baek JM;Lee Y;Liu C;Model JB;Yang G;Ghaffari R;Huang Y;Efimov IR;Rogers JA
• 通讯作者: Rogers JA

Fully implantable and bioresorbable cardiac pacemakers without leads or batteries.

• DOI: 10.1038/s41587-021-00948-x
• 发表时间: 2021-10
• 期刊: NATURE BIOTECHNOLOGY
• 影响因子: 46.9
• 作者: Choi, Yeon Sik;Yin, Rose T.;Pfenniger, Anna;Koo, Jahyun;Avila, Raudel;Benjamin Lee, K.;Chen, Sheena W.;Lee, Geumbee;Li, Gang;Qiao, Yun;Murillo-Berlioz, Alejandro;Kiss, Alexi;Han, Shuling;Lee, Seung Min;Li, Chenhang;Xie, Zhaoqian;Chen, Yu-Yu;Burrell, Amy;Geist, Beth;Jeong, Hyoyoung;Kim, Joohee;Yoon, Hong-Joon;Banks, Anthony;Kang, Seung-Kyun;Zhang, Zheng Jenny;Haney, Chad R.;Sahakian, Alan Varteres;Johnson, David;Efimova, Tatiana;Huang, Yonggang;Trachiotis, Gregory D.;Knight, Bradley P.;Arora, Rishi K.;Efimov, Igor R.;Rogers, John A.
• 通讯作者: Rogers, John A.

Hardware-Mappable Cellular Neural Networks for Distributed Wavefront Detection in Next-Generation Cardiac Implants.

用于下一代心脏植入物中分布式波前检测的硬件可映射细胞神经网络。

• DOI: 10.1002/aisy.202200032
• 发表时间: 2022
• 期刊: Advanced intelligent systems (Weinheim an der Bergstrasse, Germany)
• 作者: Yang,Zhuolin;Zhang,Lei;Aras,Kedar;Efimov,IgorR;Adam,GinaC
• 通讯作者: Adam,GinaC

Wireless, fully implantable cardiac stimulation and recording with on-device computation for closed-loop pacing and defibrillation.

• DOI: 10.1126/sciadv.abq7469
• 发表时间: 2022-10-28
• 期刊: SCIENCE ADVANCES
• 影响因子: 13.6
• 作者: Ausra, Jokubas;Madrid, Micah;Yin, Rose T.;Hanna, Jessica;Arnott, Suzanne;Brennan, Jaclyn A.;Peralta, Roberto;Clausen, David;Bakall, Jakob A.;Efimov, Igor R.;Gutruf, Philipp
• 通讯作者: Gutruf, Philipp