Role of anterior olfactory nucleus for multi-sensory integration in the olfactory system

前嗅核在嗅觉系统多感觉整合中的作用

• 批准号: 10634755
• 负责人: Thomas A Cleland
• 金额: $ 65.06万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10634755
• 关键词: Animals; Anterior; Area; Behavioral; Brain; Collaborations; Cues; Data; Decision Making; Electrophysiology (science); Exhibits; Fiber; Hippocampus; Immediate-Early Genes; Ipsilateral; Label; Learning; Maps; Measurement; Mediating; Mental Health; Neurons; Odors; Olfactory Pathways; Patients; Perception; Physiological; Play; Post-Traumatic Stress Disorders; Price; Publishing; Research; Research Personnel; Rodent; Role; Sensory; Series; Signal Transduction; Smell Perception; Stimulus; Structure; System; Testing; Time; Trauma; awake; desensitization; experimental study; hippocampal pyramidal neuron; interest; maladaptive behavior; multimodality; multisensory; neural; neural network; neurophysiology; olfactory bulb; olfactory nuclei; optogenetics; piriform cortex; response; sensory integration; spatial integration; tool

Project Summary Sensory signals encountered under different circumstances may have quite different implications. In the early olfactory system, preliminary evidence suggests that this (non-olfactory) contextual information is integrated into odor representations at a very early stage, potentially even the main olfactory bulb. Recent evidence indicates that the anterior olfactory nucleus (AON), a structure directly adjoining the olfactory bulb, serves to integrate afferent odor information with contextual information from the ventral hippocampus (vHC) and is necessary to solve contextually-dependent olfactory decision-making tasks. The vHC is known to relay task-relevant spatial contextual information to other brain systems. We here hypothesize that direct projections from the vHC to the AON play a dominant role in the integration of contextual and olfactory information, and that the AON embeds this multisensory contextual information into early-stage odor representations. Our preliminary data show that rodents can learn to respond differently to odors based on the spatial context in which they are encountered, and that the expression of such a rule depends on both AON and vHC, whereas a similar but odor-independent task requires vHC but not AON. We propose a multipronged approach to understanding the integration of spatial context into olfactory representations, engaging electrophysiological ensemble recordings and interareal coherence measurements in awake, behaving rodents, the optogenetic manipulation of vHC and AON circuit activities, and a double-labeling strategy for the within-subjects comparison of immediate-early gene (Fos) responses across two experimental conditions separated in time.

项目摘要 在不同情况下遇到的感官信号可能具有完全不同的含义。在 早期的嗅觉系统，初步证据表明，此（非野性）上下文信息是 在很早的阶段集成到气味表示中，甚至可能是主要的嗅球。最近的 证据表明，前嗅觉核（AON），一种直接毗邻嗅球的结构， 用于将传入气味信息与腹侧海马的上下文信息整合在一起 （VHC），并且对于解决上下文依赖的嗅觉决策任务是必不可少的。 已知VHC将与任务相关的空间上下文信息传达给其他大脑系统。我们在这里 假设从VHC到AON的直接预测在整合中起主要作用 上下文和嗅觉信息，并且AON将此多感觉上下文信息嵌入 早期气味表示。我们的初步数据表明，啮齿动物可以学会以不同的反应 基于遇到的空间上下文的气味，以及这种规则的表达 取决于AON和VHC，而类似但与气味无关的任务需要VHC，但不需要AON。 我们提出了一种多同时的方法来理解空间上下文中的整合到嗅觉 表示，引人入胜的电生理集合记录和内部连贯性 清醒，行为啮齿动物的测量，VHC和AON电路活动的光学遗传操作， 以及对即时基因（FOS）反应的受试者内部比较的双标记策略 在两个实验条件下，时间分开。