Circuit architecture and dynamics in odor representation and perception

气味表征和感知的电路架构和动力学

基本信息

批准号：
10390573
负责人：
Thomas A Cleland
金额：
$ 71.15万
依托单位：
STOWERS INSTITUTE FOR MEDICAL RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-01 至 2027-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10390573
关键词：
Address Affect Anatomy Animal Model Animals Architecture Area Axon Behavior Behavioral Assay Brain Cells Code Cognitive deficits Detection Discrimination Discrimination Learning Funding Genetic Goals Habitats Image Interneurons Label Learning Light Maps Memory Mental disorders Molecular Mus Nervous System Physiology Nervous system structure Neurons Odorant Receptors Odors Olfactory Cortex Olfactory Pathways Output Pathologic Pattern Perception Play Population Process Resolution Role Sensory Signal Transduction Smell Perception Stable Populations Stereotyping Stimulus Structure Testing Tetanus Toxin Theoretical model Training experience experimental study genetic approach information processing insight interdisciplinary approach olfactory bulb olfactory bulb glomeruli olfactory sensory neurons optogenetics piriform cortex public health relevance receptor relating to nervous system response segregation sensory system tool

项目摘要

7. Project Summary/Abstract. In the mammalian brain, early sensory areas are organized as stereotyped maps of stimulus qualities. The anatomical features of these sensory maps underlie the neuronal computations and information processing that are essential to generate appropriate perceptual experiences and behaviors. In the mammalian olfactory system primary olfactory sensory neurons (OSNs) expressing the same odorant receptor converge their axons into the same insular glomerular structure in the olfactory bulb. The mitral/tufted cells in the bulb received exclusively input from single glomeruli, but they project to various cortical areas with divergent output patterns. There are also extensive intercortical connections with no apparent anatomical mapping. It is not well understood how this pattern of strict convergence and segregation contributes materially to the processing of olfactory information and odor-driven behaviors. Nor is it understood the role played by the intercortical connections in the process of odor information. In this project, we establish a multi-disciplinary approach to determine the contribution of intercortical connections to odor representation and perception. Specifically, we will use activity marking to determine the stable representation of odors in various cortical areas and test the hypothesis that intercortical interactions stabilize odor representation.

7. 项目总结/摘要。在哺乳动物的大脑中，早期的感觉区域被组织成刺激质量的刻板图。这这些感觉图的解剖特征是神经元计算和信息处理的基础这对于产生适当的感知体验和行为至关重要。在哺乳动物的嗅觉中系统初级嗅觉感觉神经元（OSN）表达相同的气味受体，汇聚其轴突进入嗅球中相同的岛状肾小球结构。球茎中的二尖瓣/簇状细胞接收完全来自单个肾小球的输入，但它们投射到具有不同输出模式的各个皮质区域。还存在广泛的皮质间连接，但没有明显的解剖学映射。不太好了解这种严格融合和分离的模式如何对处理嗅觉信息和气味驱动的行为。我们也不了解皮质间的作用气味信息过程中的联系。在这个项目中，我们建立了一种多学科方法确定皮质间连接对气味表征和感知的贡献。具体来说，我们将使用活动标记来确定气味在各个皮质区域的稳定表现并测试皮质间相互作用稳定气味表征的假设。