Neural basis of behavior in freely moving macaques

自由移动猕猴行为的神经基础

• 批准号: 10832869
• 负责人: BENJAMIN Y HAYDEN
• 金额: $ 58.39万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10832869
• 关键词: 3-Dimensional; Animals; Anterior; Anxiety Disorders; Architecture; Area; Behavior; Behavior Control; Behavioral; Brain; Brain region; Categories; Classification; Cognition; Cognitive; Data; Dimensions; Disease; Dorsal; Eating; Electrodes; Electrophysiology (science); Environment; Failure; Goals; Health Benefit; Human; Implant; Joints; Laboratories; Link; Macaca; Macaca mulatta; Maintenance; Mental Depression; Mental Health; Monkeys; Motor; Movement; Mus; Neurons; Pattern; Population; Positioning Attribute; Prefrontal Cortex; Primates; Process; Ramp; Regulation; Research; Role; Sampling; Structure; System; Testing; Walking; Work; addiction; adjudication; body position; cingulate cortex; cognitive function; comorbidity; experimental study; fly; high dimensionality; improved; insight; interest; model organism; neural; neuroregulation; response; temporal measurement

Abstract Behavior and its associated executive processes can be categorized into lower-level movements, but also into higher-level states. States are controlled on a moment-to-moment basis by goals and likely implemented by specific brain circuits, including dorsal prefrontal cortical structures. The ability to properly select behaviors and to switch between them is critical for healthy cognitive functioning. Disruption of state control is a hallmark of addiction. Understanding how the brain implements and switches between states therefore offers the hope of improve their control. The central premise of this proposal is that understanding the neural control of states in macaques can help us understand neural control of states more generally. We believe this is best done in freely moving animals because behavioral expression is too constrained to be interpretable in typical laboratory contexts. A major barrier is the difficulty in tracking macaques’ body positions, which is essential for state identification. We have recently solved the tracking problem. Using an electrophysiological recording system amenable to recording in a freely moving environment, we will record responses of hundreds of neurons in dorsal anterior cingulate cortex (dACC) and the dorsolateral prefrontal cortex (dlPFC). These cortical regions, which are unique (dlPFC) or greatly modified (dACC) in the primate order, are strongly associated with control of behavior, are associated with simple cognitive states and with regulation of behavior in humans, and are prominently dysregulated in addiction. They also have strong and direct projections to the primary and secondary motor systems, putting them in an ideal position to drive behavior, and suggesting they may have a high-level relationship with control of behavior. However, while they are linked to these processes, we know almost nothing about their neuron-level relationship with control of behavior. We will place animals in our large cage system and have them perform a foraging task in which they naturally cycle through behaviors and then link them with brain activity in dACC and dlPFC. This will let us resolve several outstanding issues, including what role these regions have in behavioral control and how they relate to each other.

抽象的 行为及其相关的执行过程可以分为低级运动，但 也进入高级国家。国家以目标的瞬间为基础控制国家，可能 由特定的脑回路（包括背前皮质结构）实施。正确的能力 选择行为并在它们之间切换对于健康的认知功能至关重要。国家的破坏 控制是成瘾的标志。了解大脑如何在状态之间实施和切换 因此，人们希望改善他们的控制。该提议的主要前提是了解 猕猴中国家的神经控制可以帮助我们更普遍地了解对状态的神经控制。我们 认为这是在自由移动动物中最好完成的，因为行为表达太过限制了 在典型的实验室环境中可以解释。一个主要的障碍是追踪猕猴的身体位置的困难， 这对于国家识别至关重要。我们最近解决了跟踪问题。使用一个 电生理记录系统适合在自由移动环境中记录，我们将记录 背侧扣带回皮层（DACC）和多边形前额叶的数百个神经元的反应 皮质（DLPFC）。这些是独特（DLPFC）或大量修改（DACC）的皮质区域 顺序，与行为控制密切相关，与简单的认知状态相关联，与 对人类行为的调节，并在成瘾中显着失调。他们也有强大的 将项目直接到主要和二级运动系统，使它们处于理想的位置 行为，并暗示它们可能与对行为的控制有高级关系。但是，当他们 与这些过程相关联，我们几乎对他们的神经级别的关系一无所知 行为。我们将将动物放在我们的大笼子系统中，并让它们执行觅食任务 自然地通过行为循环，然后将它们与DACC和DLPFC中的大脑活动联系起来。这会让我们 解决几个杰出的问题，包括这些地区在行为控制中的作用以及如何 彼此相关。