Myeloid Cells: From Birth to Immunity and Disease

骨髓细胞：从出生到免疫和疾病

• 批准号: 10391781
• 负责人: Thale Cross Jarvis
• 金额: $ 1万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-11-22 至 2022-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10391781
• 关键词: Alberta province; Area; Biological; Biology; Birth; Canada; Cell Death; Cell Differentiation process; Cell Shape; Cell physiology; Cells; Collaborations; Complex; Cues; Development; Disease; Disease Progression; Educational workshop; Feedback; Fostering; Homeostasis; Immune; Immunity; Immunologics; Infection; Inflammatory; Innate Immune System; International; Knowledge; Life Style; Malignant Neoplasms; Mentors; Metabolic; Methodology; Microbe; Myelogenous; Myeloid Cells; Nervous System Physiology; Nervous system structure; Neurologic; Neurons; Organ; Outcome; Pathway interactions; Play; Proteomics; Regulatory Pathway; Research; Research Personnel; Role; Scientist; Signal Pathway; Signal Transduction; Talents; Tissues; Work; cancer cell; career; cell determination; cell growth regulation; clinical practice; experience; fascinate; human disease; innate immune sensing; meetings; microbiome; multidisciplinary; neoplastic cell; next generation; novel; pathogen; posters; programs; response; single cell sequencing; success; symposium; synergism; tool; tumor

ABSTRACT Support is requested for a Keystone Symposia conference entitled Myeloid Cells: From Birth to Immunity and Disease, organized by Drs. Venizelos Papayannopoulos, Claudia Jakubzick and Martin Guilliams. The conference will be held in Banff, Alberta, Canada from March 6 - 9, 2022. Myeloid cells are the workhorses of the innate immune system. They are essential for survival and play central roles in human disease. Recent developments have uncovered novel roles for myeloid cells in orchestrating immune defense, tissue homeostasis, metabolic state, and neurological function. These functions are regulated by complex cellular signaling pathways and a fascinating network of interactions with other host cells and microbes and the microbiome. Myeloid cells can also be deregulated to promote inflammatory, metabolic, degenerative and neurological conditions and hijacked by pathogens and tumor cells to promote infection and cancer. The conference will explore the diverse biological roles of myeloid cells and highlight the pathways that define myeloid cell identity. One unique aspect of this conference is that one focus on the program will be on how myeloid cell differentiation is tuned by lifestyle, immunological and metabolic cues to shape cell function. The program will also cover the interactions between myeloid cells and other immune cells, tumors, the stroma and neuronal compartments. The conference will highlight the latest developments in our understanding of the cell biological, metabolic and signaling mechanisms that regulate myeloid cell responses. Attendees will leave the conference with a comprehensive view of how myeloid cell differentiation and cellular regulation impacts function in homeostasis and disease. This perspective will promote synergy across research areas and identify exciting future research directions.

抽象的 请求支持题为“骨髓细胞：从出生到免疫”的 Keystone Symposia 会议，以及 疾病，由博士组织。韦尼泽洛斯·帕帕扬诺普洛斯、克劳迪娅·雅库布齐克和马丁·吉利姆斯。这 会议将于2022年3月6日至9日在加拿大艾伯塔省班夫举行。 骨髓细胞是先天免疫系统的主力。它们对于生存至关重要并起着核心作用 在人类疾病中的作用。最近的发展揭示了骨髓细胞在协调中的新作用 免疫防御、组织稳态、代谢状态和神经功能。这些功能是 受到复杂的细胞信号传导途径和与其他宿主细胞相互作用的迷人网络的调节 以及微生物和微生物组。骨髓细胞也可能失调，促进炎症、代谢、 退行性和神经系统疾病并被病原体和肿瘤细胞劫持以促进感染和 癌症。会议将探讨骨髓细胞的多种生物学作用，并强调骨髓细胞的多种生物学作用 定义骨髓细胞身份。本次会议的一个独特之处是该计划的重点将是 骨髓细胞分化如何通过生活方式、免疫和代谢线索来调节以塑造细胞功能。 该计划还将涵盖骨髓细胞与其他免疫细胞、肿瘤、基质之间的相互作用 和神经元区室。会议将重点介绍我们对这一领域理解的最新进展 调节骨髓细胞反应的细胞生物学、代谢和信号传导机制。与会者将离开 会议全面探讨骨髓细胞分化和细胞调节的影响 体内平衡和疾病中的功能。这一观点将促进跨研究领域的协同作用 确定令人兴奋的未来研究方向。