Innate Immune Memory: From Evolutionary Roots to Human Disease

先天免疫记忆：从进化根源到人类疾病

• 批准号: 10391377
• 负责人: Thale Cross Jarvis
• 金额: $ 1.5万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-01 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10391377
• 关键词: Alberta province; Area; Attention; Autoimmune Diseases; Basic Science; Biology; Bone Marrow; Canada; Cancer Biology; Cells; Characteristics; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communicable Diseases; Disease; Disease Outcome; Educational workshop; Ensure; Environment; Functional disorder; Future; Generations; Health Sciences; Host Defense; Human; Human Pathology; Immune; Immune checkpoint inhibitor; Immunity; Immunologic Memory; Immunology; Immunotherapeutic agent; Immunotherapy; Industrialization; Infection; Inflammation; Inflammatory; Innate Immune Response; International; Invertebrates; Knowledge; Learning; Malignant Neoplasms; Mammals; Mediating; Memory; Metabolic; Methodology; Methods; Molecular Biology; Molecular Immunology; Monoclonal Antibodies; Natural Immunity; Outcome; Pathogenesis; Pathology; Physiology; Plant Roots; Plants; Play; Process; Research; Research Personnel; Role; Students; Technology; Therapeutic; Training; Translations; Tumor Immunity; Vaccination; Vertebrates; Work; chimeric antigen receptor T cells; clinical implementation; clinical practice; human disease; interest; meetings; next generation; novel; posters; progenitor; symposium; vaccinology

ABSTRACT Support is requested for a Keystone Symposia conference entitled Innate Immune Memory: From Evolutionary Roots to Human Disease, organized by Drs. Mihai G. Netea, Shabaana A. Khader and Triantafyllos Chavakis. The conference will be held in Banff, Alberta, Canada from March 6-9, 2022. Memory characteristics of innate immune responses (also termed ‘trained immunity’) have been recognized only recently, with a multitude of studies demonstrating their importance for long-term broad protection against infections. Innate immune memory has been demonstrated to have deep evolutionary roots in plants and invertebrates, but also plays an important role in the host defense of vertebrates in general, and mammals in particular. In humans, innate immune memory is important for host defense against infections, and may enhance anti-tumor immunity, but can also contribute to pathogenesis in inflammatory and autoimmune diseases. The emergence of novel types of immunotherapy is having a profound impact on disease outcomes in several major pathologies such as cancer, autoimmune diseases and even severe infections. However, the immunotherapeutic research has largely focused on targeting adaptive immune cells (e.g., checkpoint inhibitors, CAR-T cells, monoclonal antibodies), with relatively little attention to innate immune cells. This conference intends to change this by serving as an international forum to highlight innate immune processes of relevance to immunotherapies. This meeting is a unique platform, in which researchers from several important fields (immunology, evolutionary biology, cancer biology, infectious diseases and physiology, clinical and health sciences) will be able to interact and exchange ideas, methods and build collaborations: this is emerging as one of the most exciting areas in immunology, and the proposed Keystone Symposium has the chance to give a strong impetus to this novel field of research.

抽象的 请求支持Keystone研讨会会议标题为“先天免疫记忆：来自进化论” 由Drs组织的人类疾病的根。 Mihai G. Netea，Shabaana A. Khader和Triantafyllos Chavakis。 该会议将于2022年3月6日至9日在加拿大艾伯塔省的班夫举行。 先天免疫调查的记忆特征（也称为“受过训练的免疫功能”）已被认可 直到最近，许多研究表明了它们对长期保护的重要性 感染。已经证明先天免疫记忆在植物中具有深厚的进化根源 无脊椎动物，但在一般的脊椎动物宿主防御中也起着重要作用，在 特别的。在人类中，先天免疫记忆对于宿主防御感染很重要，可能 增强抗肿瘤免疫学，但也可以导致炎症和自身免疫性的发病机理 疾病。新型免疫疗法的出现对疾病结局产生了深远的影响 在几种主要病理中，例如癌症，自身免疫性疾病，甚至严重的感染。但是， 免疫治疗研究主要集中在靶向适应性免疫细胞上（例如检查点 抑制剂，CAR-T细胞，单克隆抗体），对先天免疫细胞的关注相对较少。这 会议的意图是通过作为国际论坛来强调先天免疫程序来改变这一点 与免疫疗法有关。这次会议是一个独特的平台，其中一些重要的研究人员 领域（免疫学，进化生物学，癌症生物学，传染病和生理学，临床和 健康科学）将能够互动和交流思想，方法和建立合作：这是新兴的 作为免疫学中最令人兴奋的领域之一，拟议的Keystone研讨会有机会 为这个新颖的研究领域提供强大的动力。