Microwave Imaging for Neoadjuvant Chemotherapy Monitoring

用于新辅助化疗监测的微波成像

• 批准号: 9040121
• 负责人: PAUL M MEANEY
• 金额: $ 76.87万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9040121
• 关键词: Academic Medical Centers; Adipose tissue; Algorithms; Attention; Breast; Clinic; Clinical; Clinical Research; Community Healthcare; Computer software; Coupling; Data; Diagnostic; Electronics; Engineering; Enrollment; Ensure; Evaluation; Frequencies; Goals; Health; Image; Imaging Techniques; Imaging technology; Infusion procedures; Left; Lighting; Link; Liquid substance; Magnetic Resonance Imaging; Malignant Neoplasms; Measurement; Medical Oncology; Modification; Monitor; Motor; Neoadjuvant Therapy; Noise; Normal tissue morphology; Optics; Outcome; Patient Monitoring; Patients; Pilot Projects; Process; Property; Pump; Recovery; Research; Scanning; Site; Specificity; Speed; Staging; Surface; System; Techniques; Technology; Three-Dimensional Image; Time; TimeLine; Translating; base; breast imaging; breast scan; chemotherapy; cost; data acquisition; design; dielectric property; graphical user interface; imaging modality; imaging system; improved; industry partner; innovation; interest; malignant breast neoplasm; meetings; microwave electromagnetic radiation; portability; predicting response; prototype; reconstruction; research clinical testing; research study; response; standard of care; tomography; treatment response; tumor; tumor progression; user-friendly

DESCRIPTION (provided by applicant): Microwave tomographic imaging of the breast has successfully advanced to initial clinical testing for monitoring treatment response to breast cancer neoadjuvant chemotherapy. The Dartmouth microwave imaging team has performed over 500 breast exams in both diagnostic and therapy monitoring settings which have demonstrated that recovered images of the endogenous dielectric properties are highly specific to distinguishing tumor from normal tissue, and to following response to therapy. In initial therapy monitoring patient studies, results indicate that images acquired as early as 30 days after the start of treatment correlate well with pathological outcomes. In this project, the Dartmouth microwave imaging group will team with General Electric's (GE's) Global Research Center to further refine and optimize the current technology as an important step towards translating it into the clinic. Design modifications are conceived to advance the technology using best engineering practices and to prepare it for a two center imaging study. Because the current system utilizes a modest amount of measurement data and has the lowest computational requirements of any microwave tomographic system world-wide, the overall costs will remain low and system configuration simplicity will be preserved. Designing for a second site will require a significant level of additional rigor be applied to the current system to ensure that it an be operated reliably and efficiently at a remote site. Refinements will incorporate previously proven spatial prior techniques designed to isolate the dielectric property recovery in pre-determined zones - specifically in tumor, and fibroglandular and adipose tissues without unduly biasing the final images. In addition, multi-frequency imaging methods will be refined and added to increase the spectral content of the recovered data and subsequently to improve the specificity of the reconstruction process. Each of these innovations will be incorporated into the new compact and portable design where special attention has been paid to clinical workflow requirements.

描述（由申请人提供）：乳房的微波断层扫描成像已成功地进行了初始临床测试，以监测对乳腺癌新辅助化学疗法的治疗反应。达特茅斯微波成像团队在诊断和治疗监测环境中都进行了500多次乳房检查，这些检查表明，内源性介电特性的恢复图像高度特异性对于将肿瘤与正常组织区分开，以及对治疗的反应后。在最初的治疗监测患者研究中，结果表明，治疗开始后30天获得的图像与病理结局息息相关。在这个项目中，达特茅斯微波成像小组将与通用电气（GE）全球研究中心合作，进一步完善并优化当前技术，这是将其转化为诊所的重要一步。设计了设计修改，以使用最佳工程实践来推进技术，并为两个中心成像研究做准备。由于当前的系统利用了适度的测量数据，并且在全球任何微波断层扫描系统中具有最低的计算要求，因此总体成本将保持低，并且系统配置简单性将被保留。为第二个站点设计将需要大量的额外严格性，以确保在远程站点上可靠，有效地操作它。改进将结合先前经过证实的空间先验技术，旨在隔离预定区域中的介电性能回收 - 特别是在肿瘤中，以及纤维岩和脂肪组织，而不会过度偏向最终图像。此外，将完善并添加多频成像方法，以增加恢复数据的光谱含量，然后随后提高重建过程的特异性。这些创新中的每一个都将纳入新的紧凑型和便携式设计中，其中已特别注意临床工作流程要求。