Simultaneous Microwave and MR Imaging for Improved Diagnosis of Breast Abnormalities

同时微波和 MR 成像可改善乳房异常的诊断

• 批准号: 10338160
• 负责人: PAUL M MEANEY
• 金额: $ 58.12万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10338160
• 关键词: 3-Dimensional; Address; Anatomy; Benign; Biomedical Engineering; Breast; Breast Cancer Detection; Breast Magnetic Resonance Imaging; Clinical; Clinical Research; Clinical Trials Design; Custom; Data; Development; Diagnosis; Diagnostic; Diagnostic Specificity; Diffusion Magnetic Resonance Imaging; Electronics; Funding; Future; Gadolinium; Goals; Healthcare Systems; Image; Imaging Techniques; Injections; Magnetic Resonance Imaging; Malignant Neoplasms; Mammary Gland Parenchyma; Maps; Measurement; Noise; Outcome; Participant; Patients; Performance; Physics; Principal Investigator; Procedures; Process; Property; Radiology Specialty; Recovery; Research; Resolution; Rotation; Safety; Serial Magnetic Resonance Imaging; Signal Transduction; Specificity; Structure; System; Technology; Testing; Time; Tissue imaging; Tissues; Translations; Uncertainty; Water; Woman; base; breast exam; breast imaging; breast lesion; clinical imaging; contrast enhanced; cost; density; design; diagnostic accuracy; diagnostic screening; electrical property; experience; experimental study; image reconstruction; imaging platform; imaging potential; imaging properties; imaging system; improved; improved outcome; industry partner; innovation; interest; malignant breast neoplasm; microwave electromagnetic radiation; microwave imaging; multimodality; prototype; reconstruction; research clinical testing; secondary endpoint; standard of care; tissue mapping; tumor microenvironment

PROJECT SUMMARY/ABSTRACT This Academic-Industry Partnership, AIP, proposal (PAR-18-009) will develop and evaluate an innovative multi-modality breast imaging platform that performs simultaneous Microwave and Magnetic Resonance Imaging (sMMRI). It incorporates a multiple-principal-investigator (multi-PI) research plan and AIP governance structure that leverages expertise from Dartmouth, Dartmouth-Hitchcock, and Quality Electrodynamics (QED) in biomedical engineering, MRI and microwave physics, computational inversion and estimation, and breast radiology. Industry partner QED will apply its extensive experience in design and implementation of specialized MRI coils that will be fully integrated and compatible with Dartmouth’s microwave imaging (MI) electronics and in-bore antenna array. To date, we have demonstrated technical feasibility of sMMRI and have realized a prototype that has delivered the first successful clinical breast exams. While potential promise of sMMRI has been suggested, especially in terms of acquiring quantitatively-accurate spatial maps of tissue electrical properties (i.e. permittivity and conductivity), further technical innovations are needed and more experience with sMMRI, both technically and clinically, is required to develop the technology sufficiently for a full clinical evaluation. To advance and optimize sMMRI of the breast while also increasing our understanding of its clinical potential, we propose to (1) develop and integrate MRI (receive) coils with MI antenna arrays to optimize MRI and MI image quality, and breast coverage during an sMMRI clinical breast exam, (2) estimate breast tissue electrical properties from sMMRI data by encoding MRI anatomical priors into the 3D reconstruction process, and (3) complete phantom and clinical breast imaging experiments with sMMRI to evaluate and optimize the proposed technical developments, and to conduct a clinical study in women with undiagnosed breast abnormalities to test the hypothesis that sMMRI improves the specificity of breast MR alone. If the studies we propose are successful, we will have realized an innovative multi-modality breast imaging platform that is ready for involvement in larger statistically-powered clinical studies of its diagnostic performance in the future.

项目摘要/摘要 这种学术行业伙伴关系，AIP，提案（PAR-18-009）将开发和评估创新的 多模式性乳房成像平台，同时进行微波和磁共振 成像（SMMRI）。它结合了多重质评估者（Multi-PI）研究计划和AIP治理 利用达特茅斯，达特茅斯 - 奇库和优质电动力学的结构（QED） 在生物医学工程，MRI和微波物理学，计算反转和估计以及乳房 放射学。行业合作伙伴QED将在设计和实施专业的设计和实施中运用其丰富的经验 将完全集成并与达特茅斯的微波成像（MI）电子和 孔内天线阵列。迄今为止，我们已经证明了SMMRI的技术可行性，并意识到了 原型进行了首次成功的临床乳房检查。虽然SMMRI的潜在希望 提出了建议，特别是在获取组织电气的定量空间图方面 属性（即介电和电导率），需要进一步的技术创新和更多的经验 在技​​术上和临床上，SMMRI都需要充分开发该技术以进行完整的临床 评估。促进和优化乳房的SMMRI，同时也增加了我们对其临床的理解 潜力，我们建议（1）与MI天线阵列开发和整合MRI（接收）线圈以优化MRI 和MI图像质量以及SMMRI临床乳房检查期间的乳房覆盖范围，（2）估计乳房组织 通过将MRI解剖学先验编码到3D重建过程中，来自SMMRI数据的电特性， （3）使用SMMRI进行完整的幻影和临床乳房成像实验，以评估和优化 拟议的技术发展，并对未诊断乳房的女性进行临床研究 测试SMMRI可提高单独乳腺MR的特异性的假设的异常。如果研究我们 提案成功，我们将意识到一个创新的多模式乳房成像平台已准备就绪 为了参与对未来诊断性能的较大统计动力临床研究。