Microwave Spectroscopy and Imaging

微波光谱和成像

• 批准号: 6232845
• 负责人: PAUL M MEANEY
• 金额: $ 18.71万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6232845
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; breast neoplasm /cancer diagnosis; breast neoplasms; clinical research; computer program /software; computer system hardware; diagnosis design /evaluation; digital imaging; electromagnetic radiation; female; human subject; human tissue; image enhancement; mammography; microwave spectrometry; neoplastic process; women's health

Tissue sample data suggests that malignant mammary tumors have electrical properties which mimic those typically found in high-water content tissues such as muscle whereas the surrounding normal breast is more representative of low-water content fatty tissues. Presumably, the increased blood volume associated with the neovascularization in the rapidly proliferating tumor periphery is partly responsible for the increased water content which establishes a significant contrast mechanism to which microwave illumination is particularly sensitive. It has also been hypothesized that the progressive replacement of fat lobules with fibroblastic proliferation and epithelial cells and the alterations that occur at transformed cell surfaces produce ultrastructural changes in neoplastic breast tissue which cause the observed difference in electrical properties. In fact, the normal and malignant human tissues of the same histological type, the largest difference in electrical properties. In fact, for normal and malignant human tissues of the same histological type, the largest difference in electrical properties has been observed in the mammary gland relative to colon, kidney, liver, lung and muscle. This data coupled with recent advances in model-based near-field imaging concepts provide a compelling rationale to pursue microwave imaging of breast tissue for diagnostic-advantage. Project III will extent previously developed near-field microwave imaging principles and concepts of high frequency (0.5-3 GHz) electromagnetic interrogation of breast tissue for the purpose of generating spatially-resolved electrical property distributions The increase in operating frequency range can readily occur because of the largely translucent nature of breast tissue to microwave illumination and the overall small physical dimensions of the imaging region of interest. However, changing the operating frequency range drives both hardware and software design considerations which are the focus of the developmental components of this project. The specific aims of Project III can be summarized as (1) to realize a prototype 32 channel high frequency (o.5-3GHz) data acquisition system for near-field microwave illumination, (2) to implement, in conjunction with the Computational Core, new model-based image reconstruction advances including multi-component objective function minimizations, adaptive dual meshing, antenna coupling models and multi-spectral reconstructions and explore imaging method extensions, in particular,, with regard to three-dimensional imaging, (3) to evaluate and optimize phantom imaging based on geometries relevant to clinical breast examination, (4) in conjunction with the Clinical Core, demonstrate the clinical feasibility of microwave breast imaging and initiate an evaluation of the efficacy of high frequency electromagnetic property imaging as a diagnostic tool in patients with normal and abnormal mammograms

组织样品数据表明，恶性乳腺肿瘤具有电性能，这些特性模仿了那些通常在高水位含量组织（例如肌肉）中发现的那些特性，而周围的正常乳房更代表了低水含量脂肪组织。据推测，在快速增殖的肿瘤周围中与新血管化相关的血容量增加，部分原因是增加的水含量增加，该水含量建立了一种显着的对比度机制，微波照明特别敏感。还可以假设，用成纤维细胞增殖和上皮细胞进行脂肪小叶进行性替代，以及在转化的细胞表面发生的改变会导致肿瘤乳腺组织的超微结构变化，从而导致观察到的电性能差异。实际上，同一组织学类型的正常和恶性人体组织，是电性能的最大差异。实际上，对于同一组织学类型的正常和恶性人体组织，相对于结肠，肾脏，肝脏，肺和肌肉，在乳腺中观察到电性能的最大差异。这些数据加上基于模型的近场成像概念的最新进展，为追求乳腺组织的微波成像提供了一个令人信服的基本原理，以诊断诊断。项目III将在先前开发的近场微波影像学原理和高频（0.5-3 GHz）乳腺组织的电磁疑问的概念，目的是产生空间分辨的电性能分布，操作频率的增加很容易出现，因为在很大程度上是乳房组织至微型虫的物理层面的乳房组织的很大程度上，并且整体层次的层次层面是图像的整体层面。但是，更改工作频率范围驱动硬件和软件设计注意事项，这是该项目发展组成部分的重点。项目III的具体目的可以总结为（1）实现32频道高频（O.5-3GHz）的近场微波照明的数据采集系统，（2）与计算核心结合，以及基于新模型的图像重构的计算核心，包括多组分的目标功能型，Mull Multimizations，适应性型号，垂直脉络，cy，纽约，纽约。重建和探索成像方法扩展，特别是关于三维成像，（3），（3）根据与临床乳房检查相关的几何形状进行评估和优化幻象成像，（4）与临床核心结合使用，与临床核心结合使用，与临床乳房成像的临床典型性和临床性的临床性化的临床性相关性，并构成了高频率的临床性能，以实现高频率的范围，以诊断较高的频率范围，以实现高频率的频率，以实现高频率的频率，以实现高频率的范围。和异常乳房X线照片