Ultrawideband Microwave Detection of Breast Cancer`

乳腺癌的超宽带微波检测`

• 批准号: 6859914
• 负责人: SUSAN C HAGNESS
• 金额: $ 27.73万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6859914
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; breast neoplasm /cancer diagnosis; clinical biomedical equipment; clinical research; computer program /software; diagnosis design /evaluation; diagnosis quality /standard; early diagnosis; female; human subject; image processing; mathematical model; method development; microwave radiation; neoplasm /cancer classification /staging; neoplasm /cancer radiodiagnosis; noninvasive diagnosis; phantom model; three dimensional imaging /topography

DESCRIPTION (provided by applicant): IThe long-term scientific aim of this project is to develop an ultrawideband (UWB) space-time microwave imaging method for early-stage breast cancer detection. The combination of robust space-time signal processing techniques and low-power UWB microwave radar techniques offers the promise of a highly sensitive breast cancer screening tool. UWB sensing systems take advantage of the features of both lower and higher frequencies, thereby providing sufficient penetration into Iossy biological tissue and spatial (and temporal) resolution. Furthermore, super-resolution - that is, imaging resolution that overcomes the classical diffraction limit - can be achieved with UWB signals in conjunction with array-based transmitters and receivers. The goal of the proposed work is to bring about fundamental advances in UWB microwave based detection, classification, monitoring, and imaging techniques, including the design and implementation of a pre-clinical prototype imaging system and the evaluation of this novel approach using anthropomorphic breast phantoms that mimic the configuration of the patient in the clinical setting. The research will culminate with in vivo imaging studies on human research subjects. The following technical aims will be pursued to accomplish this goal: 1) To develop advanced space-time signal-processing algorithms that can be applied to UWB microwave scattered signals for the 3-D detection, imaging, classification, and monitoring of malignant breast lesions. 2) To characterize and refine the performance of our UWB imaging techniques using anatomically realistic numerical breast models and anthropomorphic physical breast tissue phantoms in conjunction with our first-and second-generation hardware prototype systems. 3) To construct a second-generation, pre-clinical prototype system suitable for in vivo imaging studies. 4) To conduct initial in vivo imaging studies with human research subjects using the pre-clinical prototype system. Successful completion of these aims will provide compelling evidence of efficacy, permit subsequent development of a microwave breast imaging system suitable for clinical trials, and lead to the establishment of low-power UWB microwave imaging as a clinically relevant non-ionizing, non-invasive tool for breast cancer detection/screening and monitoring. The predicted safety, comfort (no breast compression), ease-of-use and low-cost features should improve public compliance with annual screening recommendations.

描述（由申请人提供）： 该项目的长期科学目标是开发一种用于早期乳腺癌检测的超宽带（UWB）时空微波成像方法。强大的时空信号处理技术和低功率 UWB 微波雷达技术的结合提供了高度灵敏的乳腺癌筛查工具的前景。 UWB 传感系统利用低频和高频的特性，从而提供对 Iossy 生物组织的足够穿透力和空间（和时间）分辨率。此外，超分辨率（即克服经典衍射极限的成像分辨率）可以通过 UWB 信号与基于阵列的发射器和接收器相结合来实现。拟议工作的目标是实现基于 UWB 微波的检测、分类、监测和成像技术的根本性进步，包括临床前原型成像系统的设计和实现以及使用拟人乳房模型对这种新颖方法的评估模仿临床环境中患者的配置。该研究将以人类研究对象的体内成像研究告终。为了实现这一目标，将追求以下技术目标： 1）开发先进的时空信号处理算法，可应用于超宽带微波散射信号，用于乳腺恶性病变的 3D 检测、成像、分类和监测。 2) 使用解剖学上真实的数字乳房模型和拟人化的物理乳房组织模型以及我们的第一代和第二代硬件原型系统来表征和完善我们的 UWB 成像技术的性能。 3）构建适合体内成像研究的第二代临床前原型系统。 4) 使用临床前原型系统对人类研究对象进行初步体内成像研究。成功完成这些目标将提供令人信服的功效证据，允许后续开发适合临床试验的微波乳腺成像系统，并导致低功率 UWB 微波成像作为临床相关的非电离、非侵入性工具的建立用于乳腺癌检测/筛查和监测。预计的安全性、舒适性（无乳房压迫）、易用性和低成本特性将提高公众对年度筛查建议的遵守程度。