Dielectric Characterization of Human Breast Tissue

人类乳腺组织的介电特性

• 批准号: 6621845
• 负责人: SUSAN C HAGNESS
• 金额: $ 17.92万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-05 至 2005-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6621845
• 关键词: biomedical equipment development; biophysics; biopsy; breast neoplasm /cancer diagnosis; breast neoplasms; clinical research; computer data analysis; diagnostic tests; dielectric property; early diagnosis; electrical measurement; female; human data; human tissue; mammary gland; method development; microwave radiation; neoplasm /cancer classification /staging; statistics /biometry; women's health

The objective of the proposed research is to conduct a comprehensive set of measurements to determine the dielectric properties of malignant, benign, and normal breast tissues over a broad frequency range from 100 MHz to 20 GHz. The outcome of the proposed research will be the baseline data needed to test two hypotheses: a) there exists a systematic and significant contrast in the dielectric properties of normal breast tissue and malignant breast lesions at microwave frequencies, and b) there exists a systematic and significant contrast in the dielectric properties of benign breast lesions and malignant breast lesions at microwave frequencies. The data resulting from these measurements are needed to facilitate the engineering of non- invasive, non-ionizing microwave technology to complement and augment early detection, diagnostic, and treatment technologies presently employed in the detection and management of breast cancer. The long-term objective of our research is to improve breast cancer screening through the use of space-time microwave imaging as a complement to X-ray mammography. The data obtained from the proposed study will permit subsequent development of a practical microwave breast imaging system for clinical trials. The specific aims are: 1) To rigorously calibrate and test coaxial needle probes that will be used with a microwave vector network analyzer to obtain the dielectric permittivities and conductivities of freshly excised breast tissue samples for frequencies up to 20 GHz. 2) To measure at physiologic temperatures and moisture contents the dielectric properties of approximately 500 breast biopsy specimens and 60 breast reduction specimens. 3) To correlate the measured dielectric properties data with the complete surgical pathology reports for every breast biopsy and breast reduction specimen; the database will include fatty and fibroglandular normal breast tissue, benign tumors and proliferative lesions, and infiltrating and in situ carcinomas. 4) To conduct bio-electromagnetic dispersion analyses of the measured dielectric properties data and to assess the biophysical mechanisms for the observed contrasts (or lack thereof). 5) To conduct statistical analyses of the measured data to test the two tissue-dielectric-contrast hypotheses. This research will provide a scientific foundation for all future microwave technology development related to the breast in the 0.1 to 20 GHz range, whether for tumor detection, monitoring, or treatment.

拟议的研究的目的是进行一组全面的测量值，以确定从100 MHz到20 GHz的广泛频率范围内恶性，良性和正常乳腺组织的介电特性。 拟议的研究的结果将是测试两个假设所需的基线数据：a）在微波频率下正常乳房组织和恶性乳房病变的介电特性中存在系统的和显着的对比，而b）在良性母乳和恶性乳房的介电特性中存在系统性和显着对比。 需要通过这些测量结果产生的数据来促进非侵入性，非电离微波技术的工程，以补充和增强目前在乳腺癌检测和管理中使用的早期检测，诊断和治疗技术。 我们研究的长期目标是通过使用时空微波成像作为X射线乳房X线摄影的补充来改善乳腺癌筛查。 从拟议的研究中获得的数据将允许随后开发用于临床试验的实用微波乳房成像系统。具体目的是：1）严格校准和测试同轴针头探针，该探针将与微波矢量网络分析仪一起使用，以获得新鲜切除的乳腺组织样品的介电渗透率和电导率，以获得20 GHz的频率。 2）在生理温度和水分含量下测量约500个乳房活检标本和60个乳房降低样本的介电特性。 3）将测得的介电性能数据与每个乳房活检和乳房还原标本的完整手术病理报告相关联；该数据库将包括脂肪和纤维状正常乳腺组织，良性肿瘤和增殖性病变，以及浸润和原位癌。 4）进行测量的介电性能数据的生物电磁分散分析，并评估观察到的对比度（或缺乏）生物物理机制。 5）对测量数据进行统计分析，以测试两个组织 - 二电 - 对比的假设。 这项研究将为与肿瘤检测​​，监测或治疗相关的0.1至20 GHz范围内与乳房有关的所有未来微波技术开发提供科学基础。