Microwave Spectroscopy and Imaging

微波光谱和成像

• 批准号: 7053023
• 负责人: PAUL M MEANEY
• 金额: $ 13.17万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7053023
• 关键词: mammary gland; tissues

The high contrast for breast pathology afforded by electromagnetic (EM) properties in the 300-3000 MHz range more than motivates the development of imaging technologies that seek to exploit these differences with normal tissue. Indeed, tomographic methods are attractive in this context because they generate spatial maps of imaged parameters in order to localize disease. Project III, Microwave Imaging and Spectroscopy (MIS), targets the development and evaluation of broadband, multi-spectral microwave tomography for breast imaging applications. During the current funding period, Project III has successfully deployed a clinical imaging system which transceives propagating EM fields through a non-contacting antenna array under computer-controlled axial translation to deliver comfortable exams to the pendant breast immersed in a fluid used to promote signal coupling into the region of interest. This system has been involved in more than 100 clinical sessions which have (i) determined that EM breast properties are higher and more heterogeneous than expected, (ii) begun to establish the normal breast response showing statistically significant increases in property values with increasing breast radiodensity, and (iii) suggested that there is sufficient property contrast to detect screening abnormalities. These encouraging developments and early clinical results motivate a new set of technical and clinical goals for the next funding period that center on three primary areas of investigation: (a) to develop and evaluate 3D microwave imaging, (b) to understand the impact of breast tissue composition on the images produced and (c) to validate resultant images through clinical studies organized by the Clinical Core. More specifically, the Project III aims for the proposed funding period are (1) to develop 3D imaging through faster, more accurate data acquisition and concomitant software advances to exploit anatomical priors through coregistration, high frequencies and multi-spectral methods, (2) to develop, validate and utilize a probe-based measurement system for local property studies at the time of surgery but prior to histopathology on breast tissues previously imaged in vivo, (3) to validate the new system advances in phantoms and clinical cases correlated with MR (Magnetic Resonance) and (4) to continue clinical studies in.collaboration with the Clinical Core which target screening abnormalities recommended for biopsy, palpable masses on clinical breast exams and locally-advanced cancers receiving neoadjuvant therapy. If successful, it is expected that these aims will generate sufficient evidence to allow convincing estimates of the potential of MIS as an alternative for differential diagnosis, and pilot data in support of a role in treatment prognosis and therapy monitoring which would inform decisions on initiation of multi-center trials with MIS technology in the future.

300-3000 MHz中电磁（EM）特性提供的乳房病理的高对比度 范围不仅仅激发了试图利用这些差异的成像技术的发展 与正常组织。确实，在这种情况下，层析成像方法很有吸引力，因为它们会产生空间 成像参数的地图是为了定位疾病。项目III，微波成像和光谱法 （MIS），针对宽带，多光谱微波断层扫描的开发和评估 乳房成像应用。在当前的资金期间，项目III成功部署了 临床成像系统，通过非连接天线阵列传播EM场 在计算机控制的轴向翻译下，向沉浸在浸入的吊坠上进行舒适的考试 一种用于促进信号耦合到感兴趣区域的流体。该系统参与了更多 比（i）确定EM乳房特性更高且更多的100次临床课程 异质性比预期的，（ii）开始建立正常的乳房反应显示 随着乳房放射性的增加，特性值的显着增加，（iii）表明有 足够的特性形成鲜明对比，以检测筛查异常。这些令人鼓舞的发展和早期 临床结果激发了下一个融资期的新的技术和临床目标，该目标以此为中心 调查的三个主要领域：（a）开发和评估3D微波成像，（b）了解 乳房组织组成对产生的图像和（c）通过 临床核心组织组织的临床研究。更具体地说，该项目III旨在提议 资金期是（1）通过更快，更准确的数据获取和伴随的速度开发3D成像 软件通过核心管理，高频和多光谱来开发解剖学先验 方法，（2）开发，验证和利用基于探针的测量系统，用于本地性质研究 手术时间，但在先前在体内成像的乳腺组织的组织病理学之前，（3）验证 幻像和临床病例的新系统与MR（磁共振）和（4）相关的新系统发展 继续使用临床核心进行临床研究，该临床核心靶向筛查异常 建议进行活检，可在临床乳房检查和当地癌症接受 新辅助治疗。如果成功，预计这些目标将产生足够的证据以允许 令人信服地估计MIS作为鉴别诊断的替代方案的潜力，并在 支持在治疗预后和治疗监测中的作用，这将为启动的决定提供信息 将来对MIS技术进行多中心试验。