Zoonotic Swine Influenza Virus Transmission in Confined Animal Feeding Operations

人畜共患猪流感病毒在封闭式动物饲养作业中的传播

基本信息

批准号：
9323281
负责人：
Gregory Charles Gray
金额：
$ 42.73万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-08-15 至 2019-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9323281
关键词：
Adult Aerosols Age Animal Feed Animals Antibody titer measurement Area Avian Influenza A Virus Biological Assay Biological Markers Birth Cambodia China Chinese People Cities Collaborations Communicable Diseases Crowding Disease Domestic Fowls Ecology Economics Environment Epidemiology Family suidae Farming environment Future General Population Generations Genetic Geographic Information Systems Goals Health High Prevalence Home environment Human Immune response Immunologic Markers Immunologics Incubators Industrialization Industry Infection Influenza Influenza A Virus, H1N1 Subtype Influenza A virus Intervention Matched Group Modernization Mucosal Immunity Nigeria North America Occupational Peru Phylogenetic Analysis Polymerase Chain Reaction Population Porcine Influenza A Virus Prevalence Production Prospective Studies Public Health Reporting Research Research Personnel Reverse Transcription Risk Risk Factors Romania Sampling Serological Site Source Swab Thailand Time United States Virus Virus Diseases Weaning Work Zoonoses age group density enzootic epidemiology study experience influenza virus strain influenza virus vaccine influenzavirus neutralizing antibody novel novel virus operation pandemic disease pandemic influenza pathogen prospective public health relevance success swine influenza transmission process viral transmission water sampling

项目摘要

DESCRIPTION (provided by applicant): With its dense interacting populations of people, pigs, and poultry, China has been implicated as the source of the 1957 and 1968 pandemic influenza viruses and considered an epicenter for generating novel influenza virus strains. As industrialized farming has increased in China, the prevalence and variety of swine influenza viruses (SIVs) have increased. In this controlled, 5-yr project, we will collaborate with leading Chinese infectious disease researchers and employ a One Health approach (human, animal, and environment) to study SIV transmission in Confined Animal Feeding Operations (CAFOs) in mainland China. We will select CAFOs with a high prevalence of SIVs and prospectively follow the swine workers and their pigs, as well as examine the CAFO environment as a source for SIV persistence and transmission. In this collaboration, our aims are: 1) to identify and characterize enzootic and emergent SIVs, 2) to employ aerosol, fecal, environmental swabs, and water sampling to identify environmental areas with a high prevalence of SIVs, 3) to identify occupational risk factors for SIV infection, and 4) to identify serological and mucosal immunity biomarkers of protection against prevalent and emergent SIVs. This One Health approach to zoonotic influenza virus research is unique and made possible by our Chinese collaborators who have unique access to their swine production industry.

描述（由申请人提供）：中国与其密集的人群，猪和家禽相互作用，被牵涉到1957年和1968年流血流感病毒的来源，并被认为是产生新型流感病毒菌株的震中。随着中国工业化农业的增加，猪流感病毒（SIV）的流行率和多样性增加了。在这个受控的5年项目中，我们将与中国领先的传染病研究人员合作，并采用一种健康方法（人类，动物和环境）来研究中国大陆大陆动物喂养行动（CAFO）中的SIV传播。我们将选择具有SIV较高率的CAFO，并前瞻性地跟随猪工人及其猪，并检查CAFO环境作为SIV持久性和传播的来源。在这项合作中，我们的目的是：1）识别和表征Enzootic和Empresent SIV，2）使用气溶胶，粪便，环境拭子和水采样，以识别SIV较高流行率的环境领域，3），以识别SIV感染的职业风险因素，以及4）以识别抗毒液和粘膜免疫保护措施。这种对人畜共动性流感病毒研究的健康方法是独一无二的，我们的中国合作者可以独特地进入猪生产行业。