Convergence of Vitamin E, THC, Nicotine, Propylene Glycol and Glycerin Effects on Lung Inflammation When Vaped

维生素 E、THC、尼古丁、丙二醇和甘油的综合作用对电子烟时肺部炎症的影响

• 批准号: 10371746
• 负责人: Laura Elise Crotty Alexander
• 金额: $ 12.17万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-05 至 2026-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10371746
• 关键词: Acute; Adolescent and Young Adult; Adverse effects; Advertising; Aerosols; Affect; Age; Age-Years; Area; Asthma; Award; Back; Belief; CCL2 gene; Cannabinoids; Cell physiology; Cells; Chemicals; Chronic; Chronic Disease; Clinical; Clinical Research; Country; Data; Development; Devices; Disease; Drug Delivery Systems; Drug usage; Electronic cigarette; Ensure; Eosinophilia; Eotaxin; Epidemic; Evolution; Extrinsic asthma; Faculty; Feeling; Fibrosis; Financial compensation; Generations; Glycerol; Grant; Health; Heart; Host Defense; Human; IL8 gene; Immune; Immunologics; Inflammatory; Inhalant dose form; Inhalation; Institutes; Institutional Review Boards; Interleukin-4; Interleukin-5; Interleukin-6; Kidney; Lead; Learning; Life; Liver; Longitudinal Studies; Lung; Marijuana Smoking; Medicine; Memory; Mentors; Mentorship; Nasal Epithelium; National Heart, Lung, and Blood Institute; Nicotine; Paper; Patients; Persons; Phenotype; Physiological; Plasma; Population; Positioning Attribute; Propylene Glycols; Protocols documentation; Publishing; Pulmonary Function Test/Forced Expiratory Volume 1; Pulmonary Inflammation; RANTES; Recruitment Activity; Research; Research Design; Research Personnel; Running; Safety; Saliva; Smoke; Spirometry; Sputum; Techniques; Tetrahydrocannabinol; Time; Tobacco; Tobacco Industry; Training Support; Translational Research; Visit; Vitamin E; Work; age group; airway inflammation; antimicrobial; asthmatic; base; body system; career; cigarette smoke; cohort; combustible cigarette; coronavirus disease; cytokine; design; e-cigarette aerosols; electronic cigarette use; electronic cigarette user; eosinophil; epidemiologic data; experience; high risk population; high school; human subject; immunoregulation; improved; junior high school; lung injury; marijuana user; methacholine; microbiome; mid-career faculty; monocyte; neutrophil; never smoker; non-smoking; novel; patient oriented; patient oriented research; periostin; professor; recruit; sex; skills; success; systemic inflammatory response; transcriptome sequencing; vaper; vaping; vaping THC; young adult

PROJECT SUMMARY/ABSTRACT Since becoming an Associate Professor two and a half years ago, I think back to my years as an Assistant Professor and realize that my greatest moments of joy came from my mentee’s successes. Moments where they were awarded their first grant, obtained their first faculty position and a high-impact first authored paper was accepted all shine brightly in my memories. Equally important were the moments where a trainee came to see me because they were feeling unsuccessful or unmotivated, and they felt they were not going to succeed in academics, and through our conversation they arose, reassured about their good ideas, skill set and ability to move forward in a positive and productive way. Looking forward, I worry about the amount of time committed to administrative and clinical efforts and believe that obtaining protected time via this K24 will directly lead to development and enrichment in three areas: 1. Mentoring, 2. Conducting cutting-edge novel research, and 3. Learning new patient oriented research skills. I truly believe that expanding my time dedicated to mentorship will have the greatest impact out of the three, because enhancing and supporting the training of passionate, clever, dedicated trainees will lead to broader effects across medicine and academics relative to my research alone. In terms of research, e-cigarettes are drug delivery (vaping) devices that entered the country in 2007 and have exploded in terms of use, especially in adolescents and young adults whom have never smoked. We have no longitudinal data on the health effects of vaping, particularly on lung and systemic inflammation. By leveraging our existing cohort of young e-cigarette vapers at UCSD, the research proposed here can obtain longitudinal data by having these subjects return at 1 and 2 years, thus giving 3 timepoints across which changes in airway inflammation, microbiome and reactivity, and systemic inflammation can be defined. These data will help us understand which chronic diseases will arise from chronic e-cigarette use. Asthmatics are using e-cigarettes at a high rate, most likely because of the successful advertising campaigns tobacco companies have run, convincing many of the lack of adverse effects of these devices. But patients with asthma have airways and systemic inflammation, thus they are likely to be more susceptible to the pro-inflammatory and immunomodulatory effects of vaping. By again leveraging the ongoing patient-oriented research conducted by our team, I propose here to recruit vaping and non-vaping subjects with TH2-high allergic asthma to assess the effects of e-cigarette aerosol inhalation on their underlying disease state. Finally, I propose to dive deeper into clinical research design and analysis, to improve my ability to conduct high level patient oriented research and thus yield the highest quality, relevant data possible. With the support of my own mentors (Drs. Atul Malhotra and Victor Nizet), the support of UCSD, my existing fantastic research team and the mentees to come, I believe the support of this K24 will make it possible to thrive as a mentor, researcher and life-long learner.

项目摘要/摘要 自两年半前成为副教授以来，我回想起我的助手 教授并意识到，我最大的喜悦时刻来自我的成功。他们的时刻 被授予了他们的第一笔赠款，获得了他们的第一个教师职位，而高影响力的第一篇论文是 我的记忆中都明亮地接受了所有人。同样重要的是学员来看的时刻 我是因为他们感到失败或没有动力，他们觉得自己不会成功 学术界，通过我们的对话，他们出现了，放心他们的好主意，技能和能力 以积极和产品的方式前进。展望未来，我担心投入的时间 行政和临床工作，并相信通过此K24获得受保护的时间将直接导致 在三个领域的发展和富集：1。指导，2。进行尖端的新颖研究和3。 学习新的面向患者的研究技能。我真的相信，扩大我致力于Mentalship的时间 在这三者中产生最大的影响，因为增强和支持热情，聪明， 仅相对于我的研究，专门的学员将在医学和学术界产生更广泛的影响。 研究条款，电子烟是2007年进入该国的药物输送（VAPING）设备 在使用方面爆炸，特别是在从未吸烟的青少年和年轻人中。我们没有 关于烟的健康影响的纵向数据，特别是对肺部和全身注射。通过利用 我们现有的在UCSD的年轻电子烟vaper的同类，此处提出的研究可以获得纵向 通过使这些受试者在1和2年返回数据，从而给出了3个时间点，这是气道变化的3个时间点 可以定义炎症，微生物组和反应性以及全身性炎症。这些数据将帮助我们 了解慢性电子烟的使用将引起哪些慢性疾病。哮喘患者正在使用电子烟 高价，很可能是由于烟草公司成功的广告活动， 说服了这些设备缺乏不利影响。但是哮喘患者有气道和 系统性炎症，因此它们可能更容易受到促炎和 烟的免疫调节作用。再次利用正在进行的面向患者的研究 我的团队，我在这里建议用Th2高过敏性哮喘招募烟雾和非蒸气主体来评估 电子烟气雾吸入对其潜在疾病状态的影响。最后，我建议深入研究 临床研究设计和分析，以提高我进行高水平患者研究的能力以及 这产生了可能的最高质量，相关数据。在我自己的导师的支持下（Atul Malhotra博士 我相信，UCSD的支持，我现有的出色研究团队和未来的月经，我相信 这款K24的支持将使作为心理，研究人员和终身学习者蓬勃发展。