GENETICS OF REPRODUCTIVE SENESCENCE

生殖衰老的遗传学

• 批准号: 8172658
• 负责人: MARC TATAR
• 金额: $ 3.84万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172658
• 关键词: Adult; Aging; Animals; Biological Models; Computer Retrieval of Information on Scientific Projects Database; Data Analyses; Environment; Funding; Gene Expression; Genetic; Grant; Health; Hemorrhage; Human; Human Genetics; Institution; Menstrual cycle; Molecular Profiling; Monitor; Papio; Pathology; Protocols documentation; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Variant; base; genetic pedigree; indexing; reproductive; senescence

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this protocol is to establish a model system to study the genetic basis of reproductive aging. The project will study a pedigreed colony of 500 naturally aging adult baboons. The reproductive cycle will be monitored by observation and the animal bled on day 5 and 25 of the menstrual cycle. The data and analysis will identify human genetic regions responsible for variation in reproductive indices of senescence. The colony will provide extensive resources on senescence pathology and gene expression profiles of aging. The combined scale, economy, experimental environment, pedigree and marker set of the aging baboon offers an unprecedented resource to advance our understanding of aging and health in humans.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 该协议的目的是建立一个模型系统来研究生殖衰老的遗传基础。该项目将研究由 500 只自然衰老的成年狒狒组成的纯种狒狒群体。通过观察来监测生殖周期，并在月经周期的第5天和第25天对动物进行放血。数据和分析将确定导致衰老生殖指数变化的人类遗传区域。该殖民地将提供有关衰老病理学和衰老基因表达谱的广泛资源。衰老狒狒的综合规模、经济、实验环境、谱系和标记集为增进我们对人类衰老和健康的理解提供了前所未有的资源。