Translational Coordination and Dissemination Center for the SCGE Consortium

SCGE 联盟翻译协调和传播中心

• 批准号: 10666211
• 负责人: MELINDA R DWINELL
• 金额: $ 130.26万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10666211
• 关键词: Academia; Acceleration; Biological Assay; Clinic; Clinical Trials; Collaborations; Communication; Communities; Complex; Data; Data Element; Development; Education and Outreach; Educational Activities; Educational workshop; Elements; Foundations; Funding; Goals; Government; Individual; Industry; Infrastructure; Leadership; Organ; Outcome; Participant; Patients; Phase; Policies; Procedures; Process; Protocols documentation; Research Design; Research Personnel; Research Project Grants; Resources; Schedule; Series; System; Technology; Testing; Tissues; Translating; Translational Research; Translations; United States National Institutes of Health; Validation; Visualization; Wisconsin; Work; data access; data format; data management; data quality; disease-causing mutation; distributed data; ethical, legal, and social implication; experience; genome editing; medical schools; meetings; member; outreach; pre-clinical; preclinical study; programs; scientific organization; somatic cell gene editing; success; tool; translational goal; user-friendly; virtual; working group

PROJECT SUMMARY The goal of the NIH Common Fund’s Somatic Cell Genome Editing (SCGE) program is to take advances in technologies aimed at genome editing and delivery system approaches to correct disease-causing mutations developed in Phase I and translate these efforts into the clinic during Phase II. The SCGE Translational Coordination and Dissemination Center (TCDC) at the Medical College of Wisconsin (MCW) will continue the efforts of the Phase I SCGE Dissemination and Coordinating Center acting as the hub to support the three lab and clinical trials-based initiatives in a coordinated effort to facilitate the dissemination of protocols, best practices, SCGE results, and develop a network of collaboration. The SCGE TCDC at MCW brings a team of experienced investigators, platforms for effective communication and tracking of deliverables and milestones and demonstrated success in strategic collaborations within the consortium. The overall goal for the SCGE TCDC is to support the SCGE Consortium and work cooperatively with all initiatives, projects, and members to facilitate the objectives of the entire SCGE Consortium. To accomplish this, the MCW TCDC will 1) build upon and extend the current communication platforms to facilitate communication among participants, 2) develop the infrastructure to collect, digest, annotate, integrate, and distribute data and resources generated within the SCGE Consortium, and 3) create a robust platform for collaboration within the SCGE Consortium and with outside partners. The MCW TCDC will create the infrastructure to develop policies, track progress within the consortium, communicate within and beyond the consortium, develop outreach and educational activities to support the process of moving pre-clinical studies through the regulatory process, into clinical trials, and eventually to the patient. To disseminate data and resources developed within the SCGE Consortium, the SCGE Platform will be assembled to store, query, visualize, and analyze the outcomes of the SCGE initiatives. The MCW TCDC team will facilitate the administrative and management activities to support the overall success of the program.

项目概要 NIH 共同基金体细胞基因组编辑 (SCGE) 计划的目标是 旨在纠正基因组编辑和传递系统方法的技术进步 在第一阶段开发出引起疾病的突变，并将这些努力转化为临床 第二阶段：SCGE 翻译协调和传播中心 (TCDC) 威斯康星医学院 (MCW) 将继续第一阶段 SCGE 的努力 传播和协调中心作为支持三个实验室和临床的枢纽 以试验为基础的举措，协调一致地努力促进方案的传播，最好 实践、SCGE 结果，并在 MCW 建立 SCGE TCDC。 带来了经验丰富的调查人员团队、有效沟通和跟踪的平台 可交付成果和里程碑，并在战略合作方面取得了成功 SCGE TCDC 的总体目标是支持 SCGE 联盟和工作。 与所有倡议、项目和成员合作，以促进整个目标的实现 为了实现这一目标，MCW TCDC 将 1) 建立并扩展 当前的交流平台，以促进参与者之间的交流，2）开发 收集、消化、注释、集成和分发生成的数据和资源的基础设施 SCGE 联盟内部，以及 3) 在 SCGE 内部创建一个强大的协作平台 MCW TCDC 联盟将与外部合作伙伴共同创建基础设施以进行开发。 政策，跟踪联盟内部的进展，在联盟内部和外部进行沟通， 开展外展和教育活动以支持临床前研究的进程 通过监管流程，进入临床试验，并最终到达患者手中。 SCGE 联盟内开发的数据和资源，SCGE 平台将 组装用于存储、查询、可视化和分析 SCGE 计划的结果。 MCW TCDC 团队将促进行政和管理活动，以支持 该计划的总体成功。