2023 Functional Genomics of Human Brain Development and Disease Gordon Research Conference

2023年人脑发育与疾病功能基因组学戈登研究会议

基本信息

批准号：
10683598
负责人：
ELISABETH B. BINDER
金额：
$ 2万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-05 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10683598
关键词：
Academia Acceleration Alzheimer&apos s Disease Biological Assay Biotechnology Brain Brain Diseases Career Choice Clustered Regularly Interspaced Short Palindromic Repeats Collaborations Complex DNA Sequence Development Diagnostic Disease Disease Progression Education Engineering Environment Epigenetic Process Female Fostering Future Gene Expression Regulation Generations Genes Genetic study Genome engineering Genomics Goals Grant Health Hour Human Industry Learning Maps Modeling Molecular Nerve Degeneration Neuroglia Neurologic Neurons Neurosciences Research Nobel Prize Organoids Participant Patients Postdoctoral Fellow Public Health Research Research Personnel Schizophrenia Scientist Stem Cell Research Technology Therapeutic Intervention Time Translating Underrepresented Minority United States National Academy of Sciences United States National Institutes of Health Universities Variant Wisconsin Woman autism spectrum disorder career clinically actionable disorder risk diversity and inclusion empowerment environmental enrichment for laboratory animals functional genomics genetic architecture genome editing genome-wide graduate student human disease human model human stem cells improved individualized medicine informal atmosphere insight male meetings member multidisciplinary neurogenomics new technology new therapeutic target novel novel strategies posters prognostic programs stem cell model stem cells symposium tool

项目摘要

Project Summary/Abstract This 2023 Functional Genomics of Human Brain Development and Disease GRC conference seeks to bring together a multidisciplinary and diverse group of geneticists, neuroscientists, and stem cell biologists endeavoring to improve diagnostics, prognostics, and treatment of brain disease. The conference will explore (1) genomics of brain diseases, (2) applications of high-throughput genomic assays and screens, (3) technological advances in reprogramming, differentiation, and genome-engineering; (4) new insights into human brain development and disorders obtained through technologies; and (5) progress towards novel therapeutic targets and interventions. Whereas large-scale genomic studies are uncovering the complex genetic architecture of gene regulation and disease risk, the causal cellular mechanisms of disease risk and progression remain unclear. While the generation of patient-specific neurons, glia, and organoids facilitate the study of human brain development, CRISPR-based engineering approaches facilitate single or genome-wide perturbations in DNA sequence or epigenetic activity; their integration makes it possible to investigate the molecular mechanisms of disease-associated variations. Together, these approaches translate the myriad advances from large-scale genetic studies into clinically actionable information. This 2023 Functional Genomics of Human Brain Development and Disease GRC conference will contribute to improving our understanding the cellular and molecular mechanisms involved in regulating human brain development in health and disease. The attendees are also expected to form new connections with the leaders in industry and academia for setting new collaborations and starting new careers.

项目概要/摘要 2023 年人类大脑发育和疾病功能基因组学 GRC 会议旨在带来由遗传学家、神经科学家和干细胞生物学家组成的多学科、多元化的团队致力于改善脑部疾病的诊断、预后和治疗。会议将探讨 (1) 脑疾病基因组学，(2) 高通量基因组分析和筛选的应用，(3) 重编程、分化和基因组工程方面的技术进步；（四）新认识人类大脑的发育和通过技术获得的疾病； (5) 小说的进展治疗目标和干预措施。尽管大规模基因组研究正在揭示复杂的基因调控和疾病风险的遗传结构、疾病风险的因果细胞机制和进展仍不清楚。虽然患者特异性神经元、神经胶质细胞和类器官的生成促进了研究人类大脑发育，基于 CRISPR 的工程方法促进单个或全基因组 DNA 序列或表观遗传活性的扰动；它们的集成使研究成为可能疾病相关变异的分子机制。这些方法共同转化了无数从大规模遗传学研究到临床可操作信息的进展。 2023 年人脑发育和疾病功能基因组学 GRC 会议将有助于提高我们对调节人脑的细胞和分子机制的理解健康和疾病的发展。与会者也有望与领导人建立新的联系在工业界和学术界建立新的合作并开始新的职业生涯。