2023 Neurotrophic Mechanisms in Health and Disease

2023 健康与疾病中的神经营养机制

基本信息

批准号：
10654336
负责人：
Rejji Kuruvilla
金额：
$ 2万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-03-01 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10654336
关键词：
Academia Acceleration Address Adoption Adult Affect Alzheimer&apos s Disease Area Award Axon Basic Science Behavior Biology Breast Feeding COVID-19 Cells Cellular biology Child Care Chronic Clinical Clinical Trials Collaborations Communication Communities Computing Methodologies Dedications Dendrites Development Disease Environment Family Fostering Friends Funding Goals Growth Growth Factor Health Human Immune signaling Industry Infant Care Inflammation Knowledge Maintenance Malignant Neoplasms Mental Depression Mental disorders Methodology Methods Molecular Natural regeneration Nervous System Nervous System Physiology Neurodegenerative Disorders Neuroglia Neurologic Neurons Neurosciences Ointments Pathology Pediatric Neoplasm Physiology Postdoctoral Fellow Privatization Reagent Recording of previous events Regulation Research Research Personnel Role Schedule Scientist Signal Transduction Site Students Synaptic plasticity System Systems Biology Therapeutic Time Translating Translations Travel Underrepresented Populations Universities Woman Work career childcare allowance chronic pain cohort community-level factor developmental disease diversity and inclusion faculty mentor insight interest meetings multidisciplinary myelination nervous system development nervous system disorder neurogenesis neuron development neuron loss neuronal survival neurotrophic factor novel strategies optogenetics programs recruit repaired stem cell biology stem cell niche stem cells symposium tissue regeneration tissue repair tool translational applications translational medicine tumor progression virtual

项目摘要

Abstract This proposal is to provide support for early career investigators, post-doctoral fellows, and students to attend the Gordon Research Conference (GRC) on Neurotrophic Mechanisms in Health and Disease and the accompanying Gordon Research Seminar (GRS). The GRC will be held in Salve Regina University Newport RI from May 28-June 2 2023, and the GRS on May 27-28. Neurotrophic factors, broadly defined as factors that have critical roles in circuit connectivity, synaptic plasticity, and behavior, are essential for the development, maintenance, repair, and functions of the nervous system. Importantly, several treatments that exploit knowledge of neurotrophin biology are now in human clinical trials for chronic pain, Alzheimer's disease, and cancer. This GRC is the primary forum for bringing together diverse communities of basic researchers and clinicians investigating growth factor biology in the nervous system. The 2023 Neurotrophic Mechanisms in Health and Disease GRC is unique in bringing together a multi- disciplinary group of researchers in areas spanning fundamental problems in molecular, cellular, and developmental neuroscience to translating neurotrophin biology into therapies. The meeting will provide an important venue to integrate basic research on neurotrophic factor biology with clinical needs and industry interest, with the ultimate goal of accelerating the development and adoption of new treatments for human neurodevelopmental and neurological conditions, psychiatric diseases, and some forms of cancers. The conference will bring together speakers, many new to the meeting, who will speak to the intersection of neurotrophin biology with circuit formation, neuron-glia/immune signaling, stem cell biology, chronic pain, depression, tissue repair, and neurological disorders. Additional topics and late-breaking developments will be incorporated via talks selected from abstracts, specifically encouraging participation of junior researchers. Several features distinguish the 2023 GRC Neurotrophic Factor conference from earlier meetings. These include an emphasis on the intersection of neurotrophin biology with neuron-glia/immune signaling, stem cells, tissue repair, and therapeutic avenues, recruitment of a cohort of investigators new to the meeting who will speak to these emerging areas and provide fresh perspectives, robust representation of speakers who are women (57.1%), and from historically under-represented groups in academia (20%), introduction of an associated two- day GRS for students and postdoctoral scientists to facilitate networking among junior scientists, and introduction of a faculty mentoring system for junior trainees.

抽象的该提案旨在为早期职业研究人员、博士后研究员和学生提供支持参加关于健康和疾病的神经营养机制的戈登研究会议 (GRC) 伴随戈登研究研讨会（GRS）。 GRC 将在罗德岛州纽波特 Salve Regina 大学举行 2023年5月28日至6月2日，GRS于5月27日至28日。神经营养因子，广义上定义为在电路连接、突触可塑性和行为中发挥关键作用，对于发育至关重要，神经系统的维护、修复和功能。重要的是，一些利用知识的治疗方法神经营养蛋白生物学的研究成果目前正在进行针对慢性疼痛、阿尔茨海默病和癌症的人体临床试验。这 GRC 是汇集不同社区的基础研究人员和临床医生的主要论坛研究神经系统中的生长因子生物学。 2023 年健康与疾病神经营养机制 GRC 的独特之处在于汇集了多种涵盖分子、细胞和分子等基本问题领域的学科研究人员发育神经科学将神经营养蛋白生物学转化为疗法。会议将提供将神经营养因子生物学基础研究与临床需求和产业相结合的重要场所兴趣，最终目标是加速人类新疗法的开发和采用神经发育和神经系统疾病、精神疾病和某些形式的癌症。这会议将汇集发言者，其中许多是新参加会议的人，他们将就各领域的交叉点发表讲话神经营养蛋白生物学与电路形成、神经胶质细胞/免疫信号传导、干细胞生物学、慢性疼痛、抑郁症、组织修复和神经系统疾病。其他主题和最新进展将通过从摘要中选出的演讲纳入其中，特别鼓励初级研究人员的参与。 2023 年 GRC 神经营养因子会议与之前的会议有几个特点。这些包括强调神经营养蛋白生物学与神经元胶质细胞/免疫信号传导、干细胞、组织修复和治疗途径，招募一批新参加会议的研究人员来发言为这些新兴领域提供新的视角和强有力的女性演讲者代表性（57.1%），以及学术界历史上代表性不足的群体（20%），引入了相关的两面向学生和博士后科学家的日间GRS，以促进初级科学家之间的交流，以及介绍为初级学员建立教师指导制度。