Uranium as an Environmental Risk Factor for Cancer Among the Navajo

铀是纳瓦霍人癌症的环境危险因素

• 批准号: 8182473
• 负责人: TED A. WEINERT
• 金额: $ 21.36万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8182473
• 关键词: Address; Area; Biological Availability; Biological Models; Cells; Chronic; Complex; Environment; Environmental Risk Factor; Exposure to; Investigation; Isotopes; Life Style; Malignant Neoplasms; Measures; Mining; Native Americans; Navajo; Research; Research Project Grants; Risk; Soil; Source; Students; Testing; Training; Uranium; Water; Work; cancer health disparity; cancer prevention; experience; remediation; soil sampling

PROJECT SUMMARY (See instructions): BACKGROUND: The overall objective of the Partnership for Native America Cancer Prevention is to alleviate the unequal burden of cancer among Native Americans of the Southwest through research, training and outreach programs. NACP is a partnership between Northern Arizona University and the developed and implemented at the two institutions. Programs are designed to facilitate the entry of Native Americans into biomedical research and health care professions while engaging communities in research and training relevant to their needs. Research projects include laboratory, field-based, and community-based participatory research. All programs involving communities originate in communities and are developed and implemented in partnership with NACP students and faculty. AIMS: 1. To continue to increase the competitive stance of cancer research and training at NAU by adding new cancer researchers and by continuing strong faculty development programs for all junior faculty. 2. To develop programs that facilitate the successful transition of Native American students into our programs and that enhance the retention and graduation of Native Americans undergraduates in biomedical sciences. 3. To develop sustainable community education programs and research for cancer prevention that meet the unique needs of the Hopi Tribe and the Navajo and Tohono O'odham Nations. METHODS: Three cancer research projects are included (1) Analysis of the roles of genes and chromosome rearrangements in genomic instability, (2) Uranium as environmental risk factor for cancer among the Navajo and (3) Allostery, Protein Complexes and Cellular Distribution for the Nitric Oxide Receptor, Soluble Guanylyl Cyclase. All research projects employ Native American student researchers. The goal of the training program is to increase the number of Native American students entering careers in cancer research and healthcare. Programs will be implemented increase the numbers of entering Freshmen and tribal and community colleges in our programs, and an undergraduate training program will be implemented to prepare students to enter graduate research and professional programs. The goal of the outreach program is to strengthen collaboration between NAU and AZCC/UA with the Hopi, Navajo and Tohono O'odham tribal communities to increase community cancer prevention activities and cancer control training for health professionals that will result in increases in the numbers of Native Americans who receive cancer screening.

项目摘要（请参阅说明）： 背景：预防美国原住民癌症伙伴关系的总体目标是通过研究，培训和外展计划来减轻西南美洲原住民癌症的不平等负担。 NACP是北亚利桑那大学与开发和实施的合作伙伴关系 机构。计划旨在促进美国原住民进入生物医学研究和 医疗保健专业在吸引社区参与与他们的需求相关的研究和培训时。 研究项目包括实验室，基于现场和社区的参与性研究。全部 涉及社区的计划起源于社区，并在 与NACP学生和教职员工的合作伙伴关系。 目的：1。继续增加NAU的癌症研究和培训的竞争立场 新的癌症研究人员，并通过为所有初级教师继续强大的教师发展计划。 2 制定计划，以促进美国原住民学生成功过渡到我们的计划，并 这增强了美洲原住民在生物医学科学中的保留和毕业。 3。开发可持续的社区教育计划和针对癌症预防研究的研究 霍皮部落，纳瓦霍和托霍诺·奥德汉姆国家的独特需求。 方法：包括三个癌症研究项目（1）分析基因的作用和 基因组不稳定性的染色体重排，（2）铀作为癌症的环境风险因素 在Navajo和（3）一氧化氮的变构，蛋白质复合物和细胞分布中 受体，可溶性鸟叶循环酶。所有研究项目都雇用美国原住民的学生研究人员。这 培训计划的目标是增加从事职业生涯的美国原住民的数量 癌症研究和医疗保健。将实施程序增加进入新生的数量 以及我们计划中的部落和社区学院，以及一项本科培训计划 实施以准备学生进入研究生研究和专业课程。目标的目标 外展计划将加强NAU与AZCC/UA与霍皮，纳瓦霍和 Tohono O'Odham部落社区增加社区癌症预防活动和癌症控制 对卫生专业人员的培训将导致收到的美洲原住民人数增加 癌症筛查。