Dissemination and Coordinating Center for the SCGE Consortium

SCGE 联盟传播和协调中心

基本信息

批准号：
10063999
负责人：
MELINDA R DWINELL
金额：
$ 422.02万
依托单位：
MEDICAL COLLEGE OF WISCONSIN
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-02-01 至 2023-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10063999
关键词：
Administrative Coordination Clinic Collaborations Communication Communities Data Data Element Disease Early Diagnosis Education and Outreach Educational Materials Elements Ensure Equipment and supply inventories Focus Groups Funding Funding Opportunities Future Generations Genes Genetic Diseases Goals Health Individual Infrastructure Knowledge Leadership Modeling Patients Policies Procedures Process Protocols documentation Research Personnel Research Project Grants Science Software Tools Structure Technology Testing TimeLine Translations United States National Institutes of Health Validation Work base data format data management data quality data resource data standards data tools database structure design distributed data ethical legal social implication genome editing improved innovative technologies meetings member minimal risk new technology novel strategies novel therapeutic intervention programs public repository rare genetic disorder repository somatic cell gene editing therapeutic genome editing tool working group

项目摘要

The goal of the NIH Common Fund's Somatic Cell Genome Editing (SCGE) program is to advance technologies and models that will lead to the translation of genome editing into the clinic to create new therapeutic strategies for treating both patients with rare genetic diseases, and those with common diseases. The SCGE Dissemination and Coordinating Center (DCC) will serve as the hub to promote these novel strategies and technologies to design, test, and implement approaches to treat these diseases. The SCGE DCC will support the SCGE Consortium members and work cooperatively with all groups to facilitate their scientific endeavors. To accomplish this goal, the DCC will 1) develop modes of communication for project interaction, 2) build pipelines and processes to collect, integrate, and distribute data through the SCGE Toolkit, and 3) accelerate interactions and collaborations among the groups focused on developing and testing new approaches. The DCC will create the infrastructure for information transfer among SCGE projects, to promote partnerships focused on developing, testing, and validating novel strategies to resolve genetic disorders, and to rapidly disseminate the knowledge from the SCGE to the broader scientific community. To achieve this goal, the DCC will develop a communication structure among the NIH SCGE Working Group and the project leaders, coordinate regular meetings for consortium and subcommittees, build a project management infrastructure, establish a Toolkit to disseminate results, track SCGE Consortium inventory, manage the Collaboration Opportunity Fund to support the SCGE intra-consortium partnerships, and develop educational materials. The DCC team will facilitate the administrative activities to ensure that the scientific discoveries and overall program are successful.

NIH 共同基金体细胞基因组编辑 (SCGE) 计划的目标是先进的技术和模型将导致基因组编辑转化为诊所创造新的治疗策略来治疗罕见遗传病患者，以及患有常见疾病的人。 SCGE 传播和协调中心 (DCC) 将作为推广这些新颖策略和技术的中心，以设计、测试和实施治疗这些疾病的方法。 SCGE DCC 将支持 SCGE 联盟成员并与所有团体合作，促进其科学发展努力。为了实现这一目标，DCC 将 1) 开发通信模式项目交互，2）构建管道和流程来收集、集成和分发数据通过 SCGE 工具包，以及 3) 加速各小组之间的互动和合作专注于开发和测试新方法。 DCC 将创建基础设施 SCGE 项目之间的信息传输，以促进重点发展的伙伴关系，测试和验证解决遗传性疾病并快速传播的新策略将 SCGE 的知识传播给更广泛的科学界。为了实现这一目标， DCC 将在 NIH SCGE 工作组和项目负责人，协调联盟和小组委员会的定期会议，建立项目管理基础设施、建立工具包来传播结果、跟踪 SCGE 联盟库存、管理合作机会基金以支持 SCGE 联盟内部伙伴关系，并开发教育材料。 DCC 团队将协助行政工作确保科学发现和总体计划成功的活动。