CORE--POPULATION STUDIES

核心——人口研究

基本信息

批准号：
7651456
负责人：
Robert C Young
金额：
$ 31.07万
依托单位：
FOX CHASE CANCER CENTER
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/7651456
关键词：
Africa Amendment Animals Area Arts Behavior Control Behavioral Genetics Behavioral Medicine Bioinformatics Biometry Breast Cancer Center Support Grant Cancer Control Cancer Information Service Cancer Patient Case Report Form Case-Control Studies Cells Chemoprevention Clinical Clinical Research Clinical Trials Collection Communication Complex Computer Assisted Computer Systems Development Computer software Computers Conduct Clinical Trials Cooperative Family Registry Core Facility Custom Data Data Collection Data Storage and Retrieval Database Management Systems Databases Decision Making Development Developmental Therapeutics Program Discipline Distant Electronics Enrollment Epidemiology Epidemiology Nursing Equipment and supply inventories Evaluation Family Fox Chase Cancer Center Funding Generations Genetic Counseling Genetic screening method Grant Health Insurance Portability and Accountability Act Hereditary Malignant Neoplasm Human Human Genetics Human Resources Image Analysis In Vitro Individual Informatics Information Retrieval Information Systems Intervention Location London Mails Malignant Neoplasms Malignant neoplasm of ovary Methods Modification Molecular Epidemiology Numbers Nursing Research Outcomes Research Paper Patients Peer Review Pharmacology and Toxicology Phase I Clinical Trials Population Study Preparation Prevention Prevention program Preventive Primary carcinoma of the liver cells Process Proteomics Protocols documentation Publications Purpose Qualifying Quality Control Questionnaires Radiation Oncology Range Regulation Reporting Reproduction spores Research Research Design Research Personnel Retrieval Risk Schedule Scientist Score Screening for cancer Services Smoke Software Tools Source Specimen Study Subject Supportive care System Taiwan Telephone Interviews Translational Research Validation Viral Pathogenesis Woman Workplace anticancer research base cancer genetics cancer prevention case control cohort cost data management database design design engineering design experience genetic epidemiology genetic pedigree human subject in vivo interdisciplinary approach malignant breast neoplasm member mutant novel oncology polyposis programs protein structure psychologic research study skills software development tool virology web-enabled

项目摘要

The number of large and logistically intricate research studies at Fox Chase Cancer Center (FCCC) has been steadily increasing. Many FCCC studies, including those in epidemiology, cancer control and prevention, translational research, human genetics, behavioral medicine and some animal trials employ a variety of designs that are substantially more complex than typical cancer clinical trials at FCCC. The designs of these studies often include: unique questionnaires, clinical and specimen data from large numbers of individuals (ranging from hundreds to tens of thousands); collection of longitudinal data; collection, storage and graphical display of pedigree data; online data entry and retrieval at multiple geographically distant centers; data collection using computer-aided telephone interview systems; development of specimen inventory systems; case-control and nested case-control study designs; distribution of scheduled, personalized mailings, and the collection, integration, coordination and retrieval of information generated from diverse sources and potentially stored in multiple systems. The varied populations studied in these projects and the diversity and complexity of the designs require development of study-specific computer-based tools to provide project management and coordination, and for the collection, validation, storage, and retrieval of data. The Population Studies Facility (PSF) facilitates research conducted by FCCC investigators with peer-reviewed funding by providing them access to a productive team of skilled information systems professionals. PSF personnel have substantial expertise with states-of-the-art software engineering and design as applied to cancer research. The PSF functions include development of: (a) databases for the storage and manipulation of large quantities of questionnaire, clinical, and specimen data; (b) electronic data entry and retrieval systems; (c) report generation software; (d) consistency and quality control systems; and (e) systems that provide integration and controlled exchange of data from diverse sources. The PSF developed information systems that maintain data on over 148,000 study subjects. Over the last five years, the Facility provided services to 40 investigators with peer-reviewed funding in 10 Programs from all three Divisions, representing a 38% increase over the previous funding cycle. 99% of Facility use is by investigators with peer-reviewed funding.

福克斯蔡斯癌症中心进行的大量大型且逻辑复杂的研究（FCCC）一直在稳步增长。许多 FCCC 研究，包括流行病学、癌症控制和预防、转化研究、人类遗传学、行为医学和一些动物试验，都采用了多种设计，这些设计比 FCCC 的典型癌症临床试验要复杂得多。这些研究的设计通常包括：独特的调查问卷、大量个体（从数百到数万）的临床和样本数据；收集纵向数据；谱系数据的采集、存储和图形显示；在多个地理位置相距较远的中心进行在线数据输入和检索；使用计算机辅助电话访谈系统收集数据；开发样本库存系统；病例对照和巢式病例对照研究设计；分发预定的个性化邮件，以及收集、集成、协调和检索从不同来源生成并可能存储在多个系统中的信息。这些项目中研究的不同人群以及设计的多样性和复杂性需要开发特定于研究的计算机工具来提供项目管理和协调，以及数据的收集、验证、存储和检索。人口研究设施 (PSF) 通过为 FCCC 调查人员提供由熟练的信息系统专业人员组成的高效团队的机会，利用同行评审的资金促进他们进行的研究。 PSF 人员拥有最先进软件的丰富专业知识应用于癌症研究的工程和设计。 PSF 的职能包括开发： (a) 用于存储和操作大量问卷、临床和数据的数据库样本数据； (b) 电子数据输入和检索系统； (c) 报告生成软件； (d) 一致性和质量控制系统； (e) 提供不同来源数据的集成和受控交换的系统。 PSF 开发的信息系统可维护超过 148,000 个研究对象的数据。在过去五年中，该基金为来自所有三个部门的 10 个项目的 40 名研究人员提供了同行评审资助的服务，比上一个资助周期增加了 38%。 99% 的设施使用是由具有同行评审资金的研究人员进行的。