FMRI IN BIPOLAR ILLNESS

FMRI 在双相情感障碍中的应用

• 批准号: 7627630
• 负责人: LORI L ALTSHULER
• 金额: $ 2.01万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7627630
• 关键词: Amygdaloid structure; Anterior; Area; Blood flow; Brain; Brain Mapping; Computer Retrieval of Information on Scientific Projects Database; Functional Magnetic Resonance Imaging; Funding; Grant; Institution; Lateral; Manic; Mental Depression; Mental disorders; Moods; Positron-Emission Tomography; Psychiatry; Research; Research Personnel; Research Project Grants; Resources; Signal Transduction; Source; Technology; Training; United States National Institutes of Health; Work; frontal lobe; neuroimaging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The applicant proposes to acquire training in functional neuroimaging technology, including fMRI and PET. This will expand her expertise in neuroimaging and psychiatry from the structural realm into the functional neuroanatomic domain, and further her research endeavors in attempting to understand the neuroanatomic underpinnings of psychiatric disorders. The applicant proposes to work extensively with the Brain Mapping Division at UCLA and proposes an fMRI research project to explore brain changes that occur with mood changes in mania and depression. She will look for blood flow changes that occur in the amygdala and frontal lobe as a function of changing mood state. Specifically, she will assess fMRI signal activation in the amygdala and frontal cortex (anterior cingulate, orbitofrontal and lateral prefrontal areas) in bipolar subjects as they go from either mania to euthymia or depression to euthymia.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 申请人提议获得功能性神经影像技术的培训，包括fMRI和PET。这将使她在神经影像学和精神病学方面的专业知识从结构领域扩展到功能性神经解剖领域，并进一步研究了她的研究努力，试图了解精神疾病的神经解剖学基础。申请人建议与UCLA的大脑映射划分进行广泛合作，并提出了一个fMRI研究项目，以探索随着躁狂和抑郁症的情绪变化而发生的大脑变化。她将寻找在杏仁核和额叶中发生的血流变化，这是情绪状态变化的函数。具体而言，她将评估杏仁核和额叶皮层（前扣带回，眶额和外侧前额叶区域）中的fMRI信号激活，因为它们从躁狂症转向躁狂症或抑郁症，再到安乐室。