Mapping Brain Structure to Function in Euthymic Subjects with Bipolar Disorder

将精神正常的双相情感障碍受试者的大脑结构与功能进行映射

基本信息

批准号：
8516669
负责人：
LORI L ALTSHULER
金额：
$ 11.62万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-10 至 2014-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8516669
关键词：
Affect Algorithms Amygdaloid structure Anatomy Animals Applications Grants Area Atlases Autopsy Back Behavioral inhibition Bipolar Disorder Brain Brain Mapping Brain region Brodmann&apos s area Cholesterol Chronic Clinical Cognitive Cross-Sectional Studies Data Data Set Deformity Dependence Development Disease Ensure Etiology Exploratory/Developmental Grant for Diagnostic Cancer Imaging Foundations Frustration Functional Imaging Functional Magnetic Resonance Imaging Functional disorder Future Genes Grant Gray unit of radiation dose Histologic Image Individual Investigation Lead Link Lobe Magnetic Resonance Imaging Manic Maps Measurement Measures Mechanics Mental disorders Metabolic Methods Mind Modeling Molecular Moods Myelin Neurocognitive Neurons Neurophysiology - biologic function Patients Pattern Performance Persons Population Positron-Emission Tomography Process Production Publishing Recovery Relative (related person)Research Sampling Severities Signal Transduction Structure Structure-Activity Relationship System Techniques Testing Thick Translations Weight Work base bench to bedside blood oxygen level dependent computational anatomy density design disability endophenotype experience frontal lobe gray matter insight interest myelination neural circuit neuroimaging neuropsychological novel relating to nervous system response statistics therapy development trait white matter

项目摘要

The use of functional neuroimaging techniques (e.g. functional magnetic resonance imaging-- fMRI) in combination with neuropsychological activation paradigms has served to deepen our understanding of regional brain dysfunction in psychiatric disorders, but the application of such types of functional studies to patients with bipolar disorder has been minimal. Bipolar disorder is one of the top ten causes of disability worldwide, yet the neurophysiologic basis of the disorder remains unknown. In this proposal, we will use novel computational anatomy techniques to develop average anatomic representations for coregistration with fMRI images in bipolar subjects and compare this to normal controls. Using such methods, we hope to clarify whether orbitofrontal gray and/or white matter structural deficits are primarily associated with the reduction in neural activity seen in fMRI. Specifically, we will 1) assess disease-specific alterations in neural function in the orbitofrontal cortex using fMRI tasks that activate this region; 2) explore the underlying structural etiology of orbitofrontal hypofunction using novel techniques to measure gray and white matter; and 3) determine the relationship between alteration in gray matter (cortical thickness) or white matter volume and neural function. This has not, to our knowledge, been attempted in the bipolar population. This exploration may clarify the neural/biologic underpinnings of bipolar disorder. The discovery of specific anatomic abnormalities that are associated with clear functional consequences may direct the pursuit of targeted neuropharmacologic development and lead to better treatments for patients with bipolar disorder.

功能性神经影像学技术（例如功能磁共振成像 - fMRI）在与神经心理激活范式的结合有助于加深我们对区域的理解精神疾病中的脑功能障碍，但是将这种类型的功能研究应用于患者躁郁症很小。躁郁症是全球残疾的十大原因之一，但该疾病的神经生理基础仍然未知。在此提案中，我们将使用新颖的计算解剖技术以开发平均fMRI图像中的平均解剖学表示双极受试者并将其与正常对照进行比较。使用这种方法，我们希望澄清是否眶额灰色和/或白质结构缺陷主要与神经的减少有关在fMRI中看到的活动。具体而言，我们将1）评估神经功能的特异性改变使用激活该区域的FMRI任务的轨道额皮层； 2）探索基本的结构性病因使用新技术测量灰质和白质的轨道额力障碍； 3）确定灰质（皮质厚度）的改变或白质体积与神经功能之间的关系。据我们所知，这尚未在双极人群中尝试过。这种探索可能会阐明躁郁症的神经/生物学基础。发现特定的解剖异常与明确的功能后果相关的可能导致追求目标神经药物开发并为躁郁症患者提供更好的治疗方法。