Characterizing the primary olfactory subregions of the human amygdala

表征人类杏仁核的主要嗅觉分区

• 批准号: 10594449
• 负责人: Christina Maria Zelano
• 金额: $ 43.28万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-01 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10594449
• 关键词: Accessory Olfactory Bulbs; Address; Affect; Algorithms; Amygdaloid structure; Anatomy; Anterior; Anxiety Disorders; Area; Behavior; Brain; Brain region; Cause of Death; Cell Nucleus; Clinical; Clinical Protocols; Clinical Research; Code; Data; Diffusion Magnetic Resonance Imaging; Disease; Electric Stimulation; Electroencephalography; Electrophysiology (science); Emotional; Event; Exhibits; Fiber; Food; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Human; Lateral; Measures; Medial; Mediating; Methods; Odors; Olfactory Cortex; Olfactory Pathways; Olfactory tract; Patients; Pattern; Play; Post-Traumatic Stress Disorders; Property; Psychophysics; Reproducibility; Research; Resolution; Rest; Rodent; Role; Series; Signal Transduction; Smell Perception; Structure; Techniques; Temporal Lobe Epilepsy; Testing; Time; experimental study; neural; neuroimaging; novel; olfactory bulb; social; sudden unexpected death in epilepsy; Accessory Olfactory Bulbs; Address; Affect; Algorithms; Amygdaloid structure; Anatomy; Anterior; Anxiety Disorders; Area; Behavior; Brain; Brain region; Cause of Death; Cell Nucleus; Clinical; Clinical Protocols; Clinical Research; Code; Data; Diffusion Magnetic Resonance Imaging; Disease; Electric Stimulation; Electroencephalography; Electrophysiology (science); Emotional; Event; Exhibits; Fiber; Food; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Human; Lateral; Measures; Medial; Mediating; Methods; Odors; Olfactory Cortex; Olfactory Pathways; Olfactory tract; Patients; Pattern; Play; Post-Traumatic Stress Disorders; Property; Psychophysics; Reproducibility; Research; Resolution; Rest; Rodent; Role; Series; Signal Transduction; Smell Perception; Structure; Techniques; Temporal Lobe Epilepsy; Testing; Time; experimental study; neural; neuroimaging; novel; olfactory bulb; social; sudden unexpected death in epilepsy

Several subregions of the human amygdala receive direct projections from the olfactory bulb, yet the functional and anatomical properties of these olfactory projections are not well understood. Rodent studies have begun to shed light on the functions of some of these olfactory amygdala subregions in mediating olfactory-guided social and approach/avoid behaviors. However, there are significant differences in the projections from the olfactory bulb to the amygdala between species. For example, in rodents, the medial amygdala receives highly dense fibers from the accessory olfactory bulb. In stark contrast, humans lack an accessory olfactory system entirely. There are also other apparent differences in the specific amygdalar targets of main olfactory bulb projections between species, although these targets have not been well-characterized in humans, further highlighting the need for human studies in this area. The goal of this proposal is to characterize the anatomical and functional properties of the olfactory projections into the human amygdala. We will take a multifaceted approach, combining functional neuroimaging, electrophysiology and stimulation, which will strengthen the reproducibility and rigor of our findings. The goal of Aim 1 is to anatomically and functionally localize the primary olfactory cortical regions of the human amygdala. At the structural level, we will use a novel new multi- shot diffusion-weighted imaging sequence to localize olfactory projections into amygdala subregions. At the functional level, we will use resting fMRI combined with k-means clustering algorithms to parcellate amygdalar subregions based on distinct whole-brain functional connectivity profiles, and event-related fMRI to functionally localize odor-responsive subregions of the amygdala. The goal of Aim 2 is to shed light on the roles of distinct amygdala subregions in olfactory perception. We will use event-related fMRI to acquire high-resolution multivariate signals from the amygdala during olfactory perceptual tasks. The goal of Aim 3 is to assess the necessity of the amygdala subregions in olfactory perception. We will use intracranial EEG techniques to measure different olfactory perceptual decisions during clinician-delivered, clinically prescribed, disruptive electrical stimulation directly into the human amygdala. The proposed studies will provide a detailed characterization of the functional and anatomical properties of an under-studied group of amygdala subregions, including the medial nucleus of the amygdala, the cortical amygdala and the periamygdaloid cortex. Recent studies suggest these anterior and medial amygdala areas may play a role in sudden unexpected death in epilepsy (SUDEP), which is the leading cause of death in patients with temporal lobe epilepsy and has no known cause or treatment. Furthering our understanding of the functional and structural properties of these brain regions has strong clinical importance for these patients.

人杏仁核的几个子区域从嗅球接收直接预测，但功能性 这些嗅觉预测的解剖学特性尚不清楚。啮齿动物研究已经开始 阐明了其中一些嗅觉杏仁核子区域的功能，以介导嗅觉引导的社会 并接近/避免行为。但是，嗅觉的预测存在显着差异 灯泡到物种之间的杏仁核。例如，在啮齿动物中，内侧杏仁核会受到高度致密 附件嗅球的纤维。与之形成鲜明对比的是，人类完全没有配件嗅觉系统。 主嗅球投影的特定杏仁核靶标还有其他明显的差异 在物种之间，尽管这些靶标在人类中尚未得到很好的特征，但进一步强调了 需要在这一领域进行人类研究。该提议的目的是表征解剖学和 嗅觉投影的功能特性向人杏仁核。我们将进行多方面的 方法，结合功能性神经成像，电生理学和刺激，这将增强 我们发现的可重复性和严格性。目标1的目标是在解剖和功能上定位 人杏仁核的原发性皮质区域。在结构层面，我们将使用一种新颖的新型多 射击扩散加权成像序列将嗅觉投影定位在杏仁核区域中。在 功能水平，我们将使用静止的fMRI与K-均值聚类算法结合到杏仁核 基于不同的全脑功能连接曲线的子区域以及与事件相关的fMRI 定位杏仁核的气味响应子区域。目标2的目标是阐明不同的角色 嗅觉感知中的杏仁核子区域。我们将使用与事件相关的fMRI获取高分辨率 嗅觉感知任务期间来自杏仁核的多元信号。目标3的目的是评估 在嗅觉感知中，杏仁核子区域的必要性。我们将使用颅内脑电图技术 测量临床医生分娩，临床处方，破坏性期间的不同嗅觉感知决策 直接进入人杏仁核的电刺激。拟议的研究将提供详细的 一组未研究的杏仁核子区域的功能和解剖特性的表征， 包括杏仁核的内侧核，皮质杏仁核和下藻皮层。最近的 研究表明，这些前后杏仁核区域可能在突然的意外死亡中发挥作用 癫痫（SUDEP），这是颞叶癫痫患者的主要死亡原因，没有 已知原因或治疗。进一步了解我们对这些功能和结构特性的理解 大脑区域对这些患者具有强大的临床重要性。