FMRI IN BIPOLAR ILLNESS

FMRI 在双相情感障碍中的应用

基本信息

批准号：
8363417
负责人：
LORI L ALTSHULER
金额：
$ 1.01万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-08-01 至 2012-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8363417
关键词：
Amygdaloid structure Anterior Area Blood flow Brain Brain Mapping Functional Magnetic Resonance Imaging Funding Grant Lateral Manic Mental Depression Mental disorders Modeling Moods National Center for Research Resources Positron-Emission Tomography Principal Investigator Psychiatry Research Research Infrastructure Research Project Grants Resources Signal Transduction Source Technology Training United States National Institutes of Health Work computational anatomy cost frontal lobe neuroimaging

Amygdaloid structure Anterior Area Blood flow Brain Brain Mapping Functional Magnetic Resonance Imaging Funding Grant Lateral Manic Mental Depression Mental disorders Modeling Moods National Center for Research Resources Positron-Emission Tomography Principal Investigator Psychiatry Research Research Infrastructure Research Project Grants Resources Signal Transduction Source Technology Training United States National Institutes of Health Work computational anatomy cost frontal lobe neuroimaging

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项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The applicant proposes to acquire training in functional neuroimaging technology, including fMRI and PET. This will expand her expertise in neuroimaging and psychiatry from the structural realm into the functional neuroanatomic domain, and further her research endeavors in attempting to understand the neuroanatomic underpinnings of psychiatric disorders. The applicant proposes to work extensively with the Brain Mapping Division at UCLA and proposes an fMRI research project to explore brain changes that occur with mood changes in mania and depression. She will look for blood flow changes that occur in the amygdala and frontal lobe as a function of changing mood state. Specifically, she will assess fMRI signal activation in the amygdala and frontal cortex (anterior cingulate, orbitofrontal and lateral prefrontal areas) in bipolar subjects as they go from either mania to euthymia or depression to euthymia.

该副本是利用资源的众多研究子项目之一由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持而且，副投影的主要研究员可能是其他来源提供的包括其他NIH来源。列出的总费用可能代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。申请人提议获得功能性神经影像技术的培训，包括fMRI和PET。这将使她在神经影像学和精神病学方面的专业知识从结构领域扩展到功能性神经解剖领域，并进一步研究了她的研究努力，试图了解精神疾病的神经解剖学基础。申请人建议与UCLA的大脑映射划分进行广泛合作，并提出了一个fMRI研究项目，以探索随着躁狂和抑郁症的情绪变化而发生的大脑变化。她将寻找在杏仁核和额叶中发生的血流变化，这是情绪状态变化的函数。具体而言，她将评估杏仁核和额叶皮层（前扣带回，眶额和外侧前额叶区域）中的fMRI信号激活，因为它们从躁狂症转向躁狂症或抑郁症，再到安乐室。