Mapping Brain Structure to Function in Euthymic Subjects with Bipolar Disorder

将精神正常的双相情感障碍受试者的大脑结构与功能进行映射

基本信息

批准号：
7891249
负责人：
LORI L ALTSHULER
金额：
$ 61.46万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-10 至 2014-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7891249
关键词：
Affect Algorithms Amygdaloid structure Anatomy Animals Applications Grants Area Atlases Autopsy Back Behavioral inhibition Bipolar Disorder Brain Brain Mapping Brain region Brodmann&apos s area Cholesterol Chronic Clinical Cognitive Cross-Sectional Studies Data Data Set Deformity Dependence Development Disease Ensure Etiology Exploratory/Developmental Grant for Diagnostic Cancer Imaging Foundations Frustration Functional Imaging Functional Magnetic Resonance Imaging Functional disorder Future Genes Grant Gray unit of radiation dose Histologic Image Individual Investigation Knowledge Lead Link Lobe Magnetic Resonance Imaging Manic Maps Measurement Measures Mechanics Mental disorders Metabolic Methods Mind Modeling Molecular Moods Myelin Neurocognitive Neurons Neurophysiology - biologic function Patients Pattern Performance Persons Population Positron-Emission Tomography Process Production Publishing Recovery Relative (related person)Research Sampling Schizophrenia Severities Signal Transduction Structure Structure-Activity Relationship System Techniques Testing Thick Translations Weight Work base bench to bedside blood oxygen level dependent computational anatomy density design disability endophenotype experience frontal lobe gray matter insight interest mood regulation myelination neural circuit neuroimaging neuropsychological novel public health relevance relating to nervous system response statistics therapy development trait white matter white matter damage

项目摘要

DESCRIPTION (provided by applicant): The use of functional neuroimaging techniques (e.g. functional magnetic resonance imaging-- fMRI) in combination with neuropsychological activation paradigms has served to deepen our understanding of regional brain dysfunction in psychiatric disorders, but the application of such types of functional studies to patients with bipolar disorder has been minimal. Bipolar disorder is one of the top ten causes of disability worldwide, yet the neurophysiologic basis of the disorder remains unknown. In this proposal, we will use novel computational anatomy techniques to develop average anatomic representations for coregistration with fMRI images in bipolar subjects and compare this to normal controls. Using such methods, we hope to clarify whether orbitofrontal gray and/or white matter structural deficits are primarily associated with the reduction in neural activity seen in fMRI. Specifically, we will 1) assess disease-specific alterations in neural function in the orbitofrontal cortex using fMRI tasks that activate this region; 2) explore the underlying structural etiology of orbitofrontal hypofunction using novel techniques to measure gray and white matter; and 3) determine the relationship between alteration in gray matter (cortical thickness) or white matter volume and neural function. This has not, to our knowledge, been attempted in the bipolar population. This exploration may clarify the neural/biologic underpinnings of bipolar disorder. The discovery of specific anatomic abnormalities that are associated with clear functional consequences may direct the pursuit of targeted neuropharmacologic development and lead to better treatments for patients with bipolar disorder. PUBLIC HEALTH RELEVANCE: The neurophysiologic basis of bipolar disorder remains unknown. This application proposes to compare the brain functional deficits in persons with bipolar disorder (observed during the performance of neuropsychological tasks during functional MRI) to gray and white matter volume data obtained from structural MRI. We hope to clarify whether gray and/or white matter structural deficits are associated with the reduction in neural activity seen in fMRI and in turn clarify the neural/biologic underpinnings of bipolar disorder.

DESCRIPTION (provided by applicant): The use of functional neuroimaging techniques (e.g. functional magnetic resonance imaging-- fMRI) in combination with neuropsychological activation paradigms has served to deepen our understanding of regional brain dysfunction in psychiatric disorders, but the application of such types of functional studies to patients with bipolar disorder has been minimal.躁郁症是全球残疾的十大原因之一，但该疾病的神经生理基础仍然未知。在此提案中，我们将使用新颖的计算解剖技术来开发平均的解剖学表示，以与双极受试者中的fMRI图像进行核心验证，并将其与正常对照相比。使用这种方法，我们希望阐明轨道额灰和/或白质结构缺陷是否主要与fMRI中的神经活动减少有关。具体而言，我们将使用激活该区域的fMRI任务来评估轨道额皮层中神经功能的特异性变化； 2）探索使用新型技术来测量灰质和白质的轨道额作功能障碍的基本结构病因； 3）确定灰质改变（皮质厚度）或白质体积与神经功能之间的关系。据我们所知，这尚未在双极人群中尝试过。这种探索可以阐明躁郁症的神经/生物学基础。发现与明显的功能后果相关的特定解剖异常可能会导致追求靶向的神经药物发展，并为双相情感障碍患者提供更好的治疗方法。公共卫生相关性：躁郁症的神经生理基础仍然未知。该应用建议将双相情感障碍患者的大脑功能缺陷（在功能MRI过程中的性能执行过程中观察到）与从结构MRI获得的灰色和白质量数据。我们希望澄清灰色和/或白质结构缺陷是否与fMRI中的神经活动的降低有关，进而阐明了双相情感障碍的神经/生物学基础。